| Full name: bone morphogenetic protein 1 | Alias Symbol: BMP-1 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 649 | HGNC ID: HGNC:1067 | Ensembl Gene: ENSG00000168487 | OMIM ID: 112264 |
| Drug and gene relationship at DGIdb | |||
Expression of BMP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP1 | 649 | 202701_at | 0.5030 | 0.1217 | |
| GSE20347 | BMP1 | 649 | 202701_at | 0.4015 | 0.0004 | |
| GSE23400 | BMP1 | 649 | 202701_at | 0.2941 | 0.0000 | |
| GSE26886 | BMP1 | 649 | 202701_at | 0.6317 | 0.0041 | |
| GSE29001 | BMP1 | 649 | 202701_at | 0.1618 | 0.3265 | |
| GSE38129 | BMP1 | 649 | 202701_at | 0.3217 | 0.0009 | |
| GSE45670 | BMP1 | 649 | 202701_at | 0.4136 | 0.0167 | |
| GSE53622 | BMP1 | 649 | 43015 | 0.4467 | 0.0000 | |
| GSE53624 | BMP1 | 649 | 43015 | 0.6267 | 0.0000 | |
| GSE63941 | BMP1 | 649 | 202701_at | -0.5520 | 0.1630 | |
| GSE77861 | BMP1 | 649 | 202701_at | 0.3575 | 0.0974 | |
| GSE97050 | BMP1 | 649 | A_24_P129417 | 1.0167 | 0.1279 | |
| SRP007169 | BMP1 | 649 | RNAseq | 1.5504 | 0.0079 | |
| SRP008496 | BMP1 | 649 | RNAseq | 1.6934 | 0.0000 | |
| SRP064894 | BMP1 | 649 | RNAseq | 1.5413 | 0.0000 | |
| SRP133303 | BMP1 | 649 | RNAseq | 1.5625 | 0.0000 | |
| SRP159526 | BMP1 | 649 | RNAseq | 0.5490 | 0.0893 | |
| SRP193095 | BMP1 | 649 | RNAseq | 1.6131 | 0.0000 | |
| SRP219564 | BMP1 | 649 | RNAseq | 0.9157 | 0.0195 | |
| TCGA | BMP1 | 649 | RNAseq | 0.4771 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by BMP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP1 | 649 | 4 | 10 | 16 | |
| GSE20123 | BMP1 | 649 | 4 | 10 | 16 | |
| GSE43470 | BMP1 | 649 | 4 | 9 | 30 | |
| GSE46452 | BMP1 | 649 | 13 | 13 | 33 | |
| GSE47630 | BMP1 | 649 | 10 | 8 | 22 | |
| GSE54993 | BMP1 | 649 | 2 | 14 | 54 | |
| GSE54994 | BMP1 | 649 | 9 | 17 | 27 | |
| GSE60625 | BMP1 | 649 | 3 | 0 | 8 | |
| GSE74703 | BMP1 | 649 | 4 | 7 | 25 | |
| GSE74704 | BMP1 | 649 | 3 | 7 | 10 | |
| TCGA | BMP1 | 649 | 14 | 43 | 39 |
Total number of gains: 70; Total number of losses: 138; Total Number of normals: 280.
Somatic mutations of BMP1:
Generating mutation plots.
Highly correlated genes for BMP1:
Showing top 20/722 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP1 | ETV5 | 0.73413 | 3 | 0 | 3 |
| BMP1 | ADAMTS14 | 0.696182 | 4 | 0 | 4 |
| BMP1 | NOP10 | 0.69459 | 3 | 0 | 3 |
| BMP1 | COTL1 | 0.685285 | 3 | 0 | 3 |
| BMP1 | POU5F2 | 0.684839 | 3 | 0 | 3 |
| BMP1 | PSAP | 0.680199 | 3 | 0 | 3 |
| BMP1 | KRTCAP3 | 0.678416 | 3 | 0 | 3 |
| BMP1 | DHX33 | 0.665005 | 3 | 0 | 3 |
| BMP1 | PPP1R35 | 0.661853 | 4 | 0 | 4 |
| BMP1 | TUBB2B | 0.660238 | 3 | 0 | 3 |
| BMP1 | SLC39A10 | 0.657659 | 4 | 0 | 4 |
| BMP1 | PSMG3 | 0.655674 | 5 | 0 | 5 |
| BMP1 | OCIAD2 | 0.654404 | 6 | 0 | 5 |
| BMP1 | TMC8 | 0.653241 | 3 | 0 | 3 |
| BMP1 | DLGAP1-AS1 | 0.652429 | 3 | 0 | 3 |
| BMP1 | TRAF7 | 0.650636 | 4 | 0 | 3 |
| BMP1 | TMEM132A | 0.649891 | 10 | 0 | 8 |
| BMP1 | BCAR1 | 0.649839 | 7 | 0 | 5 |
| BMP1 | TTYH3 | 0.648681 | 7 | 0 | 7 |
| BMP1 | EIF4EBP1 | 0.646868 | 5 | 0 | 4 |
For details and further investigation, click here
