| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 6 | Alias Symbol: ADAM-TS6 | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 11174 | HGNC ID: HGNC:222 | Ensembl Gene: ENSG00000049192 | OMIM ID: 605008 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS6 | 11174 | 237411_at | 0.3248 | 0.2467 | |
| GSE20347 | ADAMTS6 | 11174 | 220866_at | 0.0216 | 0.7866 | |
| GSE23400 | ADAMTS6 | 11174 | 220866_at | -0.0503 | 0.1742 | |
| GSE26886 | ADAMTS6 | 11174 | 1570351_at | 0.0996 | 0.3282 | |
| GSE29001 | ADAMTS6 | 11174 | 220866_at | -0.0359 | 0.8156 | |
| GSE38129 | ADAMTS6 | 11174 | 220866_at | -0.0548 | 0.4661 | |
| GSE45670 | ADAMTS6 | 11174 | 237411_at | 0.1481 | 0.6995 | |
| GSE53622 | ADAMTS6 | 11174 | 92179 | 0.7961 | 0.0000 | |
| GSE53624 | ADAMTS6 | 11174 | 4203 | 1.3351 | 0.0000 | |
| GSE63941 | ADAMTS6 | 11174 | 237411_at | -2.6779 | 0.0009 | |
| GSE77861 | ADAMTS6 | 11174 | 1570351_at | 0.0196 | 0.8520 | |
| GSE97050 | ADAMTS6 | 11174 | A_33_P3286953 | 0.4990 | 0.1453 | |
| SRP007169 | ADAMTS6 | 11174 | RNAseq | 3.0093 | 0.0014 | |
| SRP064894 | ADAMTS6 | 11174 | RNAseq | 1.9241 | 0.0000 | |
| SRP133303 | ADAMTS6 | 11174 | RNAseq | 1.4614 | 0.0000 | |
| SRP159526 | ADAMTS6 | 11174 | RNAseq | 0.5598 | 0.3792 | |
| SRP193095 | ADAMTS6 | 11174 | RNAseq | 1.7699 | 0.0000 | |
| SRP219564 | ADAMTS6 | 11174 | RNAseq | 0.7986 | 0.0449 | |
| TCGA | ADAMTS6 | 11174 | RNAseq | 0.1888 | 0.4024 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by ADAMTS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS6 | 11174 | 0 | 13 | 17 | |
| GSE20123 | ADAMTS6 | 11174 | 0 | 13 | 17 | |
| GSE43470 | ADAMTS6 | 11174 | 1 | 13 | 29 | |
| GSE46452 | ADAMTS6 | 11174 | 0 | 28 | 31 | |
| GSE47630 | ADAMTS6 | 11174 | 2 | 17 | 21 | |
| GSE54993 | ADAMTS6 | 11174 | 8 | 1 | 61 | |
| GSE54994 | ADAMTS6 | 11174 | 1 | 19 | 33 | |
| GSE60625 | ADAMTS6 | 11174 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS6 | 11174 | 1 | 9 | 26 | |
| GSE74704 | ADAMTS6 | 11174 | 0 | 6 | 14 | |
| TCGA | ADAMTS6 | 11174 | 4 | 50 | 42 |
Total number of gains: 17; Total number of losses: 169; Total Number of normals: 302.
Somatic mutations of ADAMTS6:
Generating mutation plots.
Highly correlated genes for ADAMTS6:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS6 | RNF17 | 0.731778 | 5 | 0 | 5 |
| ADAMTS6 | L3MBTL1 | 0.717342 | 4 | 0 | 3 |
| ADAMTS6 | LCT | 0.711444 | 5 | 0 | 5 |
| ADAMTS6 | P4HA3 | 0.709726 | 7 | 0 | 6 |
| ADAMTS6 | TRPM3 | 0.707396 | 5 | 0 | 5 |
| ADAMTS6 | SPOCD1 | 0.705558 | 5 | 0 | 4 |
| ADAMTS6 | CSGALNACT2 | 0.702122 | 5 | 0 | 5 |
| ADAMTS6 | OR1F1 | 0.702043 | 5 | 0 | 5 |
| ADAMTS6 | ZDHHC18 | 0.69841 | 3 | 0 | 3 |
| ADAMTS6 | KIR3DL3 | 0.693684 | 6 | 0 | 6 |
| ADAMTS6 | RIMS4 | 0.692585 | 3 | 0 | 3 |
| ADAMTS6 | MBL2 | 0.68968 | 3 | 0 | 3 |
| ADAMTS6 | CHSY3 | 0.688897 | 6 | 0 | 5 |
| ADAMTS6 | IFNA4 | 0.683138 | 5 | 0 | 5 |
| ADAMTS6 | P4HA2 | 0.681002 | 3 | 0 | 3 |
| ADAMTS6 | COL1A2 | 0.679332 | 4 | 0 | 3 |
| ADAMTS6 | RFX8 | 0.677097 | 3 | 0 | 3 |
| ADAMTS6 | ADAMTS12 | 0.67689 | 9 | 0 | 8 |
| ADAMTS6 | SALL4 | 0.674104 | 4 | 0 | 4 |
| ADAMTS6 | FOXN3-AS2 | 0.673791 | 5 | 0 | 5 |
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