| Full name: alcohol dehydrogenase iron containing 1 | Alias Symbol: ADHFe1|FLJ32430 | ||
| Type: protein-coding gene | Cytoband: 8q13.1 | ||
| Entrez ID: 137872 | HGNC ID: HGNC:16354 | Ensembl Gene: ENSG00000147576 | OMIM ID: 611083 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ADHFE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADHFE1 | 137872 | 227113_at | -0.2971 | 0.6112 | |
| GSE26886 | ADHFE1 | 137872 | 227113_at | -0.4931 | 0.0205 | |
| GSE45670 | ADHFE1 | 137872 | 227113_at | -0.3405 | 0.0594 | |
| GSE53622 | ADHFE1 | 137872 | 2944 | -0.8654 | 0.0000 | |
| GSE53624 | ADHFE1 | 137872 | 28656 | -0.7273 | 0.0000 | |
| GSE63941 | ADHFE1 | 137872 | 227113_at | -0.3053 | 0.4268 | |
| GSE77861 | ADHFE1 | 137872 | 227113_at | 0.0039 | 0.9831 | |
| GSE97050 | ADHFE1 | 137872 | A_33_P3300747 | -0.9172 | 0.1556 | |
| SRP064894 | ADHFE1 | 137872 | RNAseq | -0.3992 | 0.3005 | |
| SRP133303 | ADHFE1 | 137872 | RNAseq | -1.1309 | 0.0007 | |
| SRP159526 | ADHFE1 | 137872 | RNAseq | -0.7681 | 0.0744 | |
| SRP219564 | ADHFE1 | 137872 | RNAseq | -0.4942 | 0.4491 | |
| TCGA | ADHFE1 | 137872 | RNAseq | -1.1758 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ADHFE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADHFE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADHFE1 | 137872 | 14 | 1 | 15 | |
| GSE20123 | ADHFE1 | 137872 | 15 | 1 | 14 | |
| GSE43470 | ADHFE1 | 137872 | 15 | 3 | 25 | |
| GSE46452 | ADHFE1 | 137872 | 20 | 2 | 37 | |
| GSE47630 | ADHFE1 | 137872 | 23 | 1 | 16 | |
| GSE54993 | ADHFE1 | 137872 | 1 | 18 | 51 | |
| GSE54994 | ADHFE1 | 137872 | 30 | 0 | 23 | |
| GSE60625 | ADHFE1 | 137872 | 0 | 4 | 7 | |
| GSE74703 | ADHFE1 | 137872 | 13 | 2 | 21 | |
| GSE74704 | ADHFE1 | 137872 | 10 | 0 | 10 | |
| TCGA | ADHFE1 | 137872 | 49 | 5 | 42 |
Total number of gains: 190; Total number of losses: 37; Total Number of normals: 261.
Somatic mutations of ADHFE1:
Generating mutation plots.
Highly correlated genes for ADHFE1:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADHFE1 | UBXN1 | 0.804686 | 3 | 0 | 3 |
| ADHFE1 | LMO4 | 0.769369 | 3 | 0 | 3 |
| ADHFE1 | KDM3B | 0.768348 | 3 | 0 | 3 |
| ADHFE1 | TNRC6A | 0.715455 | 3 | 0 | 3 |
| ADHFE1 | CDK5RAP3 | 0.713277 | 3 | 0 | 3 |
| ADHFE1 | SESTD1 | 0.710797 | 3 | 0 | 3 |
| ADHFE1 | BHMT2 | 0.707198 | 3 | 0 | 3 |
| ADHFE1 | ARFGAP2 | 0.702928 | 3 | 0 | 3 |
| ADHFE1 | INTS6 | 0.701484 | 3 | 0 | 3 |
| ADHFE1 | FAM200B | 0.692238 | 3 | 0 | 3 |
| ADHFE1 | RBM5 | 0.69102 | 4 | 0 | 3 |
| ADHFE1 | PRKACA | 0.680522 | 3 | 0 | 3 |
| ADHFE1 | ZNF24 | 0.677359 | 3 | 0 | 3 |
| ADHFE1 | ORAI3 | 0.676776 | 4 | 0 | 3 |
| ADHFE1 | CLYBL | 0.672037 | 6 | 0 | 5 |
| ADHFE1 | RCOR3 | 0.670229 | 6 | 0 | 5 |
| ADHFE1 | EIF3F | 0.669424 | 3 | 0 | 3 |
| ADHFE1 | HBS1L | 0.666007 | 3 | 0 | 3 |
| ADHFE1 | MED28 | 0.662891 | 3 | 0 | 3 |
| ADHFE1 | USP12 | 0.660838 | 3 | 0 | 3 |
For details and further investigation, click here
