| Full name: proteasome subunit alpha 3 | Alias Symbol: HC8 | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 5684 | HGNC ID: HGNC:9532 | Ensembl Gene: ENSG00000100567 | OMIM ID: 176843 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMA3 | 5684 | 201532_at | 0.5395 | 0.0878 | |
| GSE20347 | PSMA3 | 5684 | 201532_at | 0.7220 | 0.0002 | |
| GSE23400 | PSMA3 | 5684 | 201532_at | 0.9447 | 0.0000 | |
| GSE26886 | PSMA3 | 5684 | 201532_at | 0.2052 | 0.5573 | |
| GSE29001 | PSMA3 | 5684 | 201532_at | 0.6742 | 0.0632 | |
| GSE38129 | PSMA3 | 5684 | 201532_at | 0.8940 | 0.0000 | |
| GSE45670 | PSMA3 | 5684 | 201532_at | 0.6512 | 0.0006 | |
| GSE53622 | PSMA3 | 5684 | 111063 | 0.6391 | 0.0000 | |
| GSE53624 | PSMA3 | 5684 | 111063 | 0.8771 | 0.0000 | |
| GSE63941 | PSMA3 | 5684 | 201532_at | 0.8248 | 0.0084 | |
| GSE77861 | PSMA3 | 5684 | 201532_at | 0.4869 | 0.3184 | |
| GSE97050 | PSMA3 | 5684 | A_23_P140301 | 0.2265 | 0.6933 | |
| SRP007169 | PSMA3 | 5684 | RNAseq | 0.6488 | 0.0796 | |
| SRP008496 | PSMA3 | 5684 | RNAseq | 0.5567 | 0.0137 | |
| SRP064894 | PSMA3 | 5684 | RNAseq | 0.5337 | 0.0024 | |
| SRP133303 | PSMA3 | 5684 | RNAseq | 0.5313 | 0.0032 | |
| SRP159526 | PSMA3 | 5684 | RNAseq | 0.2386 | 0.3780 | |
| SRP193095 | PSMA3 | 5684 | RNAseq | 0.2822 | 0.0542 | |
| SRP219564 | PSMA3 | 5684 | RNAseq | 0.5372 | 0.2138 | |
| TCGA | PSMA3 | 5684 | RNAseq | 0.2981 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSMA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMA3 | 5684 | 8 | 3 | 19 | |
| GSE20123 | PSMA3 | 5684 | 7 | 3 | 20 | |
| GSE43470 | PSMA3 | 5684 | 8 | 2 | 33 | |
| GSE46452 | PSMA3 | 5684 | 16 | 3 | 40 | |
| GSE47630 | PSMA3 | 5684 | 11 | 10 | 19 | |
| GSE54993 | PSMA3 | 5684 | 3 | 8 | 59 | |
| GSE54994 | PSMA3 | 5684 | 19 | 4 | 30 | |
| GSE60625 | PSMA3 | 5684 | 0 | 2 | 9 | |
| GSE74703 | PSMA3 | 5684 | 7 | 2 | 27 | |
| GSE74704 | PSMA3 | 5684 | 3 | 2 | 15 | |
| TCGA | PSMA3 | 5684 | 33 | 13 | 50 |
Total number of gains: 115; Total number of losses: 52; Total Number of normals: 321.
Somatic mutations of PSMA3:
Generating mutation plots.
Highly correlated genes for PSMA3:
Showing top 20/1300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMA3 | CDKN3 | 0.767261 | 12 | 0 | 11 |
| PSMA3 | MNAT1 | 0.760495 | 11 | 0 | 11 |
| PSMA3 | ADSL | 0.740503 | 8 | 0 | 8 |
| PSMA3 | MRPL3 | 0.728718 | 11 | 0 | 11 |
| PSMA3 | FZD6 | 0.719369 | 8 | 0 | 8 |
| PSMA3 | DLGAP5 | 0.718628 | 12 | 0 | 10 |
| PSMA3 | POLR2K | 0.715701 | 7 | 0 | 7 |
| PSMA3 | TMX1 | 0.715129 | 11 | 0 | 10 |
| PSMA3 | HPRT1 | 0.713015 | 11 | 0 | 10 |
| PSMA3 | CCNB1 | 0.710098 | 10 | 0 | 9 |
| PSMA3 | RAN | 0.707531 | 12 | 0 | 10 |
| PSMA3 | PSMC1 | 0.705634 | 10 | 0 | 8 |
| PSMA3 | WDHD1 | 0.704553 | 11 | 0 | 10 |
| PSMA3 | ILF2 | 0.704295 | 12 | 0 | 12 |
| PSMA3 | CCDC86 | 0.701167 | 6 | 0 | 6 |
| PSMA3 | GMPS | 0.700493 | 10 | 0 | 10 |
| PSMA3 | EIF2S1 | 0.696624 | 9 | 0 | 8 |
| PSMA3 | CKS1B | 0.690733 | 13 | 0 | 13 |
| PSMA3 | NIFK | 0.690462 | 5 | 0 | 4 |
| PSMA3 | MRPL13 | 0.689854 | 12 | 0 | 10 |
For details and further investigation, click here
