| Full name: kinesin family member 22 | Alias Symbol: Kid|OBP-1|OBP-2 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 3835 | HGNC ID: HGNC:6391 | Ensembl Gene: ENSG00000079616 | OMIM ID: 603213 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KIF22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF22 | 3835 | 202183_s_at | 0.9714 | 0.0656 | |
| GSE20347 | KIF22 | 3835 | 202183_s_at | 0.9008 | 0.0000 | |
| GSE23400 | KIF22 | 3835 | 202183_s_at | 0.4463 | 0.0000 | |
| GSE26886 | KIF22 | 3835 | 202183_s_at | 0.8757 | 0.0000 | |
| GSE29001 | KIF22 | 3835 | 202183_s_at | 0.7799 | 0.0169 | |
| GSE38129 | KIF22 | 3835 | 202183_s_at | 0.8430 | 0.0000 | |
| GSE45670 | KIF22 | 3835 | 202183_s_at | 0.4432 | 0.0081 | |
| GSE53622 | KIF22 | 3835 | 25348 | 0.6884 | 0.0000 | |
| GSE53624 | KIF22 | 3835 | 25348 | 0.9193 | 0.0000 | |
| GSE63941 | KIF22 | 3835 | 202183_s_at | 1.4700 | 0.0015 | |
| GSE77861 | KIF22 | 3835 | 202183_s_at | 0.5026 | 0.0105 | |
| GSE97050 | KIF22 | 3835 | A_33_P3350634 | 0.5258 | 0.1860 | |
| SRP007169 | KIF22 | 3835 | RNAseq | 0.8314 | 0.1437 | |
| SRP008496 | KIF22 | 3835 | RNAseq | 0.4956 | 0.2247 | |
| SRP064894 | KIF22 | 3835 | RNAseq | 0.9079 | 0.0001 | |
| SRP133303 | KIF22 | 3835 | RNAseq | 0.8433 | 0.0003 | |
| SRP159526 | KIF22 | 3835 | RNAseq | 1.1544 | 0.0030 | |
| SRP193095 | KIF22 | 3835 | RNAseq | 0.6495 | 0.0000 | |
| SRP219564 | KIF22 | 3835 | RNAseq | 0.8560 | 0.0194 | |
| TCGA | KIF22 | 3835 | RNAseq | 0.5190 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KIF22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF22 | 3835 | 5 | 5 | 20 | |
| GSE20123 | KIF22 | 3835 | 5 | 4 | 21 | |
| GSE43470 | KIF22 | 3835 | 3 | 3 | 37 | |
| GSE46452 | KIF22 | 3835 | 38 | 1 | 20 | |
| GSE47630 | KIF22 | 3835 | 11 | 7 | 22 | |
| GSE54993 | KIF22 | 3835 | 3 | 5 | 62 | |
| GSE54994 | KIF22 | 3835 | 5 | 9 | 39 | |
| GSE60625 | KIF22 | 3835 | 4 | 0 | 7 | |
| GSE74703 | KIF22 | 3835 | 3 | 2 | 31 | |
| GSE74704 | KIF22 | 3835 | 3 | 2 | 15 | |
| TCGA | KIF22 | 3835 | 20 | 11 | 65 |
Total number of gains: 100; Total number of losses: 49; Total Number of normals: 339.
Somatic mutations of KIF22:
Generating mutation plots.
Highly correlated genes for KIF22:
Showing top 20/1619 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF22 | RNASEH2A | 0.807804 | 12 | 0 | 12 |
| KIF22 | CDT1 | 0.800207 | 12 | 0 | 12 |
| KIF22 | UBE2T | 0.792715 | 8 | 0 | 8 |
| KIF22 | TPX2 | 0.785949 | 12 | 0 | 12 |
| KIF22 | MYBL2 | 0.784662 | 12 | 0 | 12 |
| KIF22 | AURKB | 0.775604 | 12 | 0 | 12 |
| KIF22 | CKS1B | 0.766197 | 12 | 0 | 12 |
| KIF22 | CCNB2 | 0.76597 | 11 | 0 | 11 |
| KIF22 | RFC4 | 0.765609 | 12 | 0 | 12 |
| KIF22 | BIRC5 | 0.763199 | 11 | 0 | 10 |
| KIF22 | NCAPG2 | 0.762839 | 11 | 0 | 11 |
| KIF22 | MCM2 | 0.76095 | 12 | 0 | 11 |
| KIF22 | RAD51 | 0.760687 | 11 | 0 | 11 |
| KIF22 | SPAG5 | 0.757004 | 12 | 0 | 12 |
| KIF22 | CENPN | 0.753794 | 12 | 0 | 12 |
| KIF22 | CENPF | 0.747667 | 12 | 0 | 12 |
| KIF22 | KNSTRN | 0.744816 | 7 | 0 | 7 |
| KIF22 | NUDT1 | 0.744344 | 12 | 0 | 12 |
| KIF22 | CMSS1 | 0.74396 | 6 | 0 | 6 |
| KIF22 | RNPS1 | 0.743688 | 11 | 0 | 10 |
For details and further investigation, click here
