| Full name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | Alias Symbol: FLJ20199|UPLC1|CENTB6 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 55616 | HGNC ID: HGNC:14987 | Ensembl Gene: ENSG00000088280 | OMIM ID: 616594 |
| Drug and gene relationship at DGIdb | |||
ASAP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of ASAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASAP3 | 55616 | 222236_s_at | -0.8830 | 0.0559 | |
| GSE20347 | ASAP3 | 55616 | 222236_s_at | -0.9145 | 0.0000 | |
| GSE23400 | ASAP3 | 55616 | 222236_s_at | -0.5997 | 0.0000 | |
| GSE26886 | ASAP3 | 55616 | 222236_s_at | -0.2205 | 0.2483 | |
| GSE29001 | ASAP3 | 55616 | 222236_s_at | -0.8575 | 0.0009 | |
| GSE38129 | ASAP3 | 55616 | 222236_s_at | -0.9345 | 0.0000 | |
| GSE45670 | ASAP3 | 55616 | 222236_s_at | -0.7563 | 0.0001 | |
| GSE53622 | ASAP3 | 55616 | 25547 | -1.1497 | 0.0000 | |
| GSE53624 | ASAP3 | 55616 | 17825 | -1.6306 | 0.0000 | |
| GSE63941 | ASAP3 | 55616 | 222236_s_at | -0.8312 | 0.0333 | |
| GSE77861 | ASAP3 | 55616 | 222236_s_at | -0.5896 | 0.0026 | |
| GSE97050 | ASAP3 | 55616 | A_23_P114689 | -0.6000 | 0.2151 | |
| SRP007169 | ASAP3 | 55616 | RNAseq | -1.9571 | 0.0000 | |
| SRP008496 | ASAP3 | 55616 | RNAseq | -1.8982 | 0.0000 | |
| SRP064894 | ASAP3 | 55616 | RNAseq | -0.7727 | 0.0002 | |
| SRP133303 | ASAP3 | 55616 | RNAseq | -0.9210 | 0.0002 | |
| SRP159526 | ASAP3 | 55616 | RNAseq | -0.4249 | 0.3154 | |
| SRP193095 | ASAP3 | 55616 | RNAseq | -0.9019 | 0.0000 | |
| SRP219564 | ASAP3 | 55616 | RNAseq | -0.7292 | 0.0350 | |
| TCGA | ASAP3 | 55616 | RNAseq | -0.4465 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ASAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASAP3 | 55616 | 0 | 5 | 25 | |
| GSE20123 | ASAP3 | 55616 | 0 | 4 | 26 | |
| GSE43470 | ASAP3 | 55616 | 2 | 6 | 35 | |
| GSE46452 | ASAP3 | 55616 | 5 | 1 | 53 | |
| GSE47630 | ASAP3 | 55616 | 8 | 3 | 29 | |
| GSE54993 | ASAP3 | 55616 | 2 | 1 | 67 | |
| GSE54994 | ASAP3 | 55616 | 11 | 4 | 38 | |
| GSE60625 | ASAP3 | 55616 | 0 | 0 | 11 | |
| GSE74703 | ASAP3 | 55616 | 1 | 4 | 31 | |
| GSE74704 | ASAP3 | 55616 | 0 | 0 | 20 | |
| TCGA | ASAP3 | 55616 | 9 | 23 | 64 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of ASAP3:
Generating mutation plots.
Highly correlated genes for ASAP3:
Showing top 20/1200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASAP3 | HCG22 | 0.769128 | 6 | 0 | 6 |
| ASAP3 | MGLL | 0.758426 | 10 | 0 | 10 |
| ASAP3 | FAM219B | 0.753737 | 3 | 0 | 3 |
| ASAP3 | SH3GL1 | 0.746493 | 9 | 0 | 9 |
| ASAP3 | FAM95B1 | 0.746011 | 3 | 0 | 3 |
| ASAP3 | GYS2 | 0.741036 | 10 | 0 | 9 |
| ASAP3 | AIF1L | 0.740719 | 6 | 0 | 6 |
| ASAP3 | ANXA9 | 0.740165 | 11 | 0 | 10 |
| ASAP3 | EPS8L2 | 0.738433 | 10 | 0 | 9 |
| ASAP3 | MAPK3 | 0.737343 | 11 | 0 | 10 |
| ASAP3 | PADI1 | 0.737073 | 8 | 0 | 7 |
| ASAP3 | ENDOU | 0.736667 | 11 | 0 | 10 |
| ASAP3 | SH3BGRL2 | 0.736035 | 7 | 0 | 6 |
| ASAP3 | CYP4B1 | 0.733245 | 10 | 0 | 10 |
| ASAP3 | CLIC3 | 0.732443 | 8 | 0 | 8 |
| ASAP3 | PPL | 0.731958 | 10 | 0 | 10 |
| ASAP3 | TPCN1 | 0.728178 | 10 | 0 | 9 |
| ASAP3 | RANBP9 | 0.72743 | 10 | 0 | 9 |
| ASAP3 | VAT1 | 0.727026 | 12 | 0 | 10 |
| ASAP3 | NDRG2 | 0.726808 | 9 | 0 | 8 |
For details and further investigation, click here
