| Full name: aldo-keto reductase family 1 member A1 | Alias Symbol: ALR|DD3 | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 10327 | HGNC ID: HGNC:380 | Ensembl Gene: ENSG00000117448 | OMIM ID: 103830 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR1A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1A1 | 10327 | 201900_s_at | -0.2932 | 0.7359 | |
| GSE20347 | AKR1A1 | 10327 | 201900_s_at | -0.8768 | 0.0000 | |
| GSE23400 | AKR1A1 | 10327 | 201900_s_at | -0.3258 | 0.0000 | |
| GSE26886 | AKR1A1 | 10327 | 201900_s_at | -0.7291 | 0.0001 | |
| GSE29001 | AKR1A1 | 10327 | 201900_s_at | -1.0094 | 0.0001 | |
| GSE38129 | AKR1A1 | 10327 | 201900_s_at | -0.5094 | 0.0081 | |
| GSE45670 | AKR1A1 | 10327 | 201900_s_at | -0.2640 | 0.1400 | |
| GSE53622 | AKR1A1 | 10327 | 45472 | -0.6816 | 0.0000 | |
| GSE53624 | AKR1A1 | 10327 | 45472 | -0.6326 | 0.0000 | |
| GSE63941 | AKR1A1 | 10327 | 201900_s_at | 0.4480 | 0.4242 | |
| GSE77861 | AKR1A1 | 10327 | 201900_s_at | -0.8386 | 0.0074 | |
| GSE97050 | AKR1A1 | 10327 | A_24_P79755 | 0.0953 | 0.8134 | |
| SRP007169 | AKR1A1 | 10327 | RNAseq | -1.5209 | 0.0003 | |
| SRP008496 | AKR1A1 | 10327 | RNAseq | -1.6264 | 0.0000 | |
| SRP064894 | AKR1A1 | 10327 | RNAseq | -0.2036 | 0.3611 | |
| SRP133303 | AKR1A1 | 10327 | RNAseq | -0.3500 | 0.2147 | |
| SRP159526 | AKR1A1 | 10327 | RNAseq | -0.7945 | 0.0045 | |
| SRP193095 | AKR1A1 | 10327 | RNAseq | -0.8256 | 0.0000 | |
| SRP219564 | AKR1A1 | 10327 | RNAseq | -0.4189 | 0.2791 | |
| TCGA | AKR1A1 | 10327 | RNAseq | -0.0640 | 0.2219 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by AKR1A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1A1 | 10327 | 4 | 3 | 23 | |
| GSE20123 | AKR1A1 | 10327 | 4 | 2 | 24 | |
| GSE43470 | AKR1A1 | 10327 | 7 | 2 | 34 | |
| GSE46452 | AKR1A1 | 10327 | 2 | 1 | 56 | |
| GSE47630 | AKR1A1 | 10327 | 9 | 3 | 28 | |
| GSE54993 | AKR1A1 | 10327 | 0 | 1 | 69 | |
| GSE54994 | AKR1A1 | 10327 | 12 | 2 | 39 | |
| GSE60625 | AKR1A1 | 10327 | 0 | 0 | 11 | |
| GSE74703 | AKR1A1 | 10327 | 6 | 1 | 29 | |
| GSE74704 | AKR1A1 | 10327 | 2 | 0 | 18 | |
| TCGA | AKR1A1 | 10327 | 11 | 16 | 69 |
Total number of gains: 57; Total number of losses: 31; Total Number of normals: 400.
Somatic mutations of AKR1A1:
Generating mutation plots.
Highly correlated genes for AKR1A1:
Showing top 20/1311 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1A1 | ZSCAN22 | 0.725923 | 3 | 0 | 3 |
| AKR1A1 | ANXA11 | 0.706211 | 10 | 0 | 10 |
| AKR1A1 | TXNDC17 | 0.703356 | 4 | 0 | 4 |
| AKR1A1 | CCDC6 | 0.703189 | 11 | 0 | 10 |
| AKR1A1 | SCP2 | 0.696838 | 11 | 0 | 11 |
| AKR1A1 | SMAGP | 0.693873 | 10 | 0 | 10 |
| AKR1A1 | ZNF823 | 0.692353 | 7 | 0 | 7 |
| AKR1A1 | MKS1 | 0.68761 | 3 | 0 | 3 |
| AKR1A1 | CXCR2 | 0.687048 | 9 | 0 | 9 |
| AKR1A1 | KIAA1211L | 0.68629 | 6 | 0 | 6 |
| AKR1A1 | SRP68 | 0.685966 | 4 | 0 | 3 |
| AKR1A1 | RPL41 | 0.684261 | 3 | 0 | 3 |
| AKR1A1 | MACC1 | 0.683965 | 7 | 0 | 7 |
| AKR1A1 | CMPK1 | 0.681805 | 11 | 0 | 10 |
| AKR1A1 | RASSF5 | 0.681496 | 7 | 0 | 7 |
| AKR1A1 | PHACTR4 | 0.681261 | 10 | 0 | 10 |
| AKR1A1 | ACPP | 0.678306 | 10 | 0 | 10 |
| AKR1A1 | MAGI3 | 0.675348 | 6 | 0 | 6 |
| AKR1A1 | TFAP2B | 0.675293 | 8 | 0 | 8 |
| AKR1A1 | DHCR24 | 0.67507 | 11 | 0 | 11 |
For details and further investigation, click here
