| Full name: aldehyde dehydrogenase 1 family member A3 | Alias Symbol: RALDH3 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 220 | HGNC ID: HGNC:409 | Ensembl Gene: ENSG00000184254 | OMIM ID: 600463 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH1A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH1A3 | 220 | 203180_at | -0.1842 | 0.8905 | |
| GSE20347 | ALDH1A3 | 220 | 203180_at | -1.0663 | 0.0141 | |
| GSE23400 | ALDH1A3 | 220 | 203180_at | -0.8763 | 0.0000 | |
| GSE26886 | ALDH1A3 | 220 | 203180_at | -2.6360 | 0.0000 | |
| GSE29001 | ALDH1A3 | 220 | 203180_at | -1.2952 | 0.0039 | |
| GSE38129 | ALDH1A3 | 220 | 203180_at | -0.8514 | 0.0073 | |
| GSE45670 | ALDH1A3 | 220 | 203180_at | 0.7059 | 0.1664 | |
| GSE53622 | ALDH1A3 | 220 | 25480 | -0.7104 | 0.0000 | |
| GSE53624 | ALDH1A3 | 220 | 25480 | -1.1959 | 0.0000 | |
| GSE63941 | ALDH1A3 | 220 | 203180_at | -0.8517 | 0.6604 | |
| GSE77861 | ALDH1A3 | 220 | 203180_at | -0.3253 | 0.4392 | |
| GSE97050 | ALDH1A3 | 220 | A_23_P205959 | 0.1492 | 0.8565 | |
| SRP007169 | ALDH1A3 | 220 | RNAseq | -2.5088 | 0.0011 | |
| SRP008496 | ALDH1A3 | 220 | RNAseq | -2.7702 | 0.0000 | |
| SRP064894 | ALDH1A3 | 220 | RNAseq | -1.1987 | 0.0002 | |
| SRP133303 | ALDH1A3 | 220 | RNAseq | -0.1868 | 0.5886 | |
| SRP159526 | ALDH1A3 | 220 | RNAseq | -0.9659 | 0.0177 | |
| SRP193095 | ALDH1A3 | 220 | RNAseq | -0.8539 | 0.0222 | |
| SRP219564 | ALDH1A3 | 220 | RNAseq | -0.6237 | 0.2793 | |
| TCGA | ALDH1A3 | 220 | RNAseq | 0.0266 | 0.8369 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ALDH1A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH1A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH1A3 | 220 | 7 | 2 | 21 | |
| GSE20123 | ALDH1A3 | 220 | 7 | 2 | 21 | |
| GSE43470 | ALDH1A3 | 220 | 6 | 5 | 32 | |
| GSE46452 | ALDH1A3 | 220 | 3 | 7 | 49 | |
| GSE47630 | ALDH1A3 | 220 | 9 | 10 | 21 | |
| GSE54993 | ALDH1A3 | 220 | 4 | 7 | 59 | |
| GSE54994 | ALDH1A3 | 220 | 8 | 7 | 38 | |
| GSE60625 | ALDH1A3 | 220 | 4 | 0 | 7 | |
| GSE74703 | ALDH1A3 | 220 | 5 | 4 | 27 | |
| GSE74704 | ALDH1A3 | 220 | 3 | 3 | 14 | |
| TCGA | ALDH1A3 | 220 | 18 | 12 | 66 |
Total number of gains: 74; Total number of losses: 59; Total Number of normals: 355.
Somatic mutations of ALDH1A3:
Generating mutation plots.
Highly correlated genes for ALDH1A3:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH1A3 | TMEM41B | 0.74237 | 3 | 0 | 3 |
| ALDH1A3 | PLCD3 | 0.723382 | 3 | 0 | 3 |
| ALDH1A3 | LRRC40 | 0.722781 | 3 | 0 | 3 |
| ALDH1A3 | DUSP18 | 0.721568 | 3 | 0 | 3 |
| ALDH1A3 | GLCE | 0.715251 | 5 | 0 | 5 |
| ALDH1A3 | MCC | 0.710865 | 3 | 0 | 3 |
| ALDH1A3 | ADAM10 | 0.710302 | 3 | 0 | 3 |
| ALDH1A3 | GLUD2 | 0.706405 | 5 | 0 | 4 |
| ALDH1A3 | ZFC3H1 | 0.704997 | 3 | 0 | 3 |
| ALDH1A3 | STX4 | 0.700036 | 3 | 0 | 3 |
| ALDH1A3 | PLEKHA7 | 0.69892 | 4 | 0 | 4 |
| ALDH1A3 | FBXO8 | 0.698655 | 3 | 0 | 3 |
| ALDH1A3 | ABHD12 | 0.69768 | 3 | 0 | 3 |
| ALDH1A3 | ZNHIT6 | 0.686841 | 3 | 0 | 3 |
| ALDH1A3 | KCNJ2 | 0.685594 | 3 | 0 | 3 |
| ALDH1A3 | FNTA | 0.685434 | 3 | 0 | 3 |
| ALDH1A3 | ALDOC | 0.683909 | 4 | 0 | 3 |
| ALDH1A3 | PXMP2 | 0.682264 | 4 | 0 | 3 |
| ALDH1A3 | REEP3 | 0.682121 | 5 | 0 | 4 |
| ALDH1A3 | MRPL35 | 0.678354 | 3 | 0 | 3 |
For details and further investigation, click here
