MEN1

 

Full name: menin 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q13
Entrez ID: 4221 HGNC ID: HGNC:7010 Ensembl Gene: ENSG00000133895 OMIM ID: 613733
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 9/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MEN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MEN1 4221 202645_s_at 0.7076 0.1039
GSE20347 MEN1 4221 202645_s_at 0.3058 0.0426
GSE23400 MEN1 4221 202645_s_at 0.4385 0.0000
GSE26886 MEN1 4221 202645_s_at 0.3227 0.0733
GSE29001 MEN1 4221 202645_s_at 0.4021 0.2870
GSE38129 MEN1 4221 202645_s_at 0.4653 0.0004
GSE45670 MEN1 4221 202645_s_at 0.5510 0.0002
GSE53622 MEN1 4221 46319 0.7624 0.0000
GSE53624 MEN1 4221 110621 0.7961 0.0000
GSE63941 MEN1 4221 202645_s_at 1.4647 0.0027
GSE77861 MEN1 4221 202645_s_at 0.4131 0.0791
GSE97050 MEN1 4221 A_23_P75453 1.0914 0.1291
SRP007169 MEN1 4221 RNAseq 1.2610 0.0114
SRP008496 MEN1 4221 RNAseq 0.3933 0.3327
SRP064894 MEN1 4221 RNAseq 0.6886 0.0000
SRP133303 MEN1 4221 RNAseq 0.3426 0.0361
SRP159526 MEN1 4221 RNAseq 0.6698 0.0663
SRP193095 MEN1 4221 RNAseq 0.3808 0.0012
SRP219564 MEN1 4221 RNAseq 0.2590 0.5468
TCGA MEN1 4221 RNAseq 0.2263 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by MEN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MEN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MEN1 4221 7 6 17
GSE20123 MEN1 4221 7 6 17
GSE43470 MEN1 4221 1 3 39
GSE46452 MEN1 4221 10 4 45
GSE47630 MEN1 4221 5 6 29
GSE54993 MEN1 4221 3 1 66
GSE54994 MEN1 4221 6 5 42
GSE60625 MEN1 4221 0 3 8
GSE74703 MEN1 4221 1 1 34
GSE74704 MEN1 4221 5 4 11
TCGA MEN1 4221 20 8 68

Total number of gains: 65; Total number of losses: 47; Total Number of normals: 376.  

 

Somatic mutations of MEN1:

 

Generating mutation plots.

 

Highly correlated genes for MEN1:

 

Showing top 20/1555 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MEN1ALG10.753609303
MEN1AP1S30.74397303
MEN1ZDHHC160.734747505
MEN1AP1M20.729547303
MEN1B3GNT50.720167303
MEN1SOGA10.71656403
MEN1NT5DC20.714328303
MEN1POLA20.71274411010
MEN1CAPN150.71116303
MEN1UBE2C0.70967411011
MEN1KIFC10.70952810010
MEN1NUF20.708568707
MEN1TPX20.70854911010
MEN1CDCA20.707681504
MEN1ALDH5A10.706387303
MEN1EIF2AK10.70584412011
MEN1ORAI10.705449606
MEN1SPNS10.703213404
MEN1GINS10.70236410010
MEN1TNFSF130.701669303

For details and further investigation, click here