| Full name: arachidonate 5-lipoxygenase | Alias Symbol: 5-LOX | ||
| Type: protein-coding gene | Cytoband: 10q11.21 | ||
| Entrez ID: 240 | HGNC ID: HGNC:435 | Ensembl Gene: ENSG00000012779 | OMIM ID: 152390 |
| Drug and gene relationship at DGIdb | |||
ALOX5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05145 | Toxoplasmosis |
Expression of ALOX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOX5 | 240 | 204446_s_at | -0.2796 | 0.8602 | |
| GSE20347 | ALOX5 | 240 | 204446_s_at | -1.4762 | 0.0000 | |
| GSE23400 | ALOX5 | 240 | 204445_s_at | -0.0946 | 0.0109 | |
| GSE26886 | ALOX5 | 240 | 204446_s_at | -0.6315 | 0.2489 | |
| GSE29001 | ALOX5 | 240 | 204446_s_at | -0.8472 | 0.1127 | |
| GSE38129 | ALOX5 | 240 | 204446_s_at | -0.9193 | 0.0028 | |
| GSE45670 | ALOX5 | 240 | 204446_s_at | -1.3254 | 0.0004 | |
| GSE53622 | ALOX5 | 240 | 122171 | -0.4752 | 0.0003 | |
| GSE53624 | ALOX5 | 240 | 122171 | -1.0014 | 0.0000 | |
| GSE63941 | ALOX5 | 240 | 204446_s_at | 1.6313 | 0.3609 | |
| GSE77861 | ALOX5 | 240 | 204445_s_at | -0.1136 | 0.3498 | |
| GSE97050 | ALOX5 | 240 | A_23_P104464 | 0.3035 | 0.4681 | |
| SRP007169 | ALOX5 | 240 | RNAseq | 0.4308 | 0.5641 | |
| SRP008496 | ALOX5 | 240 | RNAseq | -0.2078 | 0.6570 | |
| SRP064894 | ALOX5 | 240 | RNAseq | 0.4180 | 0.1324 | |
| SRP133303 | ALOX5 | 240 | RNAseq | -0.0456 | 0.8265 | |
| SRP159526 | ALOX5 | 240 | RNAseq | -0.7431 | 0.2429 | |
| SRP193095 | ALOX5 | 240 | RNAseq | -0.1140 | 0.5789 | |
| SRP219564 | ALOX5 | 240 | RNAseq | 0.3572 | 0.3010 | |
| TCGA | ALOX5 | 240 | RNAseq | -0.1075 | 0.4249 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ALOX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOX5 | 240 | 3 | 5 | 22 | |
| GSE20123 | ALOX5 | 240 | 3 | 5 | 22 | |
| GSE43470 | ALOX5 | 240 | 1 | 6 | 36 | |
| GSE46452 | ALOX5 | 240 | 0 | 13 | 46 | |
| GSE47630 | ALOX5 | 240 | 4 | 12 | 24 | |
| GSE54993 | ALOX5 | 240 | 9 | 0 | 61 | |
| GSE54994 | ALOX5 | 240 | 2 | 10 | 41 | |
| GSE60625 | ALOX5 | 240 | 0 | 0 | 11 | |
| GSE74703 | ALOX5 | 240 | 1 | 3 | 32 | |
| GSE74704 | ALOX5 | 240 | 2 | 4 | 14 | |
| TCGA | ALOX5 | 240 | 15 | 17 | 64 |
Total number of gains: 40; Total number of losses: 75; Total Number of normals: 373.
Somatic mutations of ALOX5:
Generating mutation plots.
Highly correlated genes for ALOX5:
Showing top 20/456 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOX5 | ICAM3 | 0.731516 | 7 | 0 | 6 |
| ALOX5 | BHLHE22 | 0.713709 | 4 | 0 | 4 |
| ALOX5 | ATP8A1 | 0.704789 | 7 | 0 | 7 |
| ALOX5 | GIMAP7 | 0.696234 | 6 | 0 | 5 |
| ALOX5 | CTSS | 0.691793 | 10 | 0 | 9 |
| ALOX5 | CD48 | 0.687867 | 9 | 0 | 7 |
| ALOX5 | ARHGEF6 | 0.684558 | 9 | 0 | 8 |
| ALOX5 | ALOX5AP | 0.682779 | 7 | 0 | 7 |
| ALOX5 | GIMAP1 | 0.680176 | 5 | 0 | 4 |
| ALOX5 | CD52 | 0.677497 | 9 | 0 | 7 |
| ALOX5 | SLCO2B1 | 0.676659 | 10 | 0 | 8 |
| ALOX5 | DOCK2 | 0.672143 | 9 | 0 | 9 |
| ALOX5 | DOCK10 | 0.660114 | 8 | 0 | 8 |
| ALOX5 | MPEG1 | 0.657163 | 6 | 0 | 5 |
| ALOX5 | ITK | 0.654827 | 8 | 0 | 7 |
| ALOX5 | EVI2A | 0.652838 | 8 | 0 | 7 |
| ALOX5 | CYYR1 | 0.651834 | 3 | 0 | 3 |
| ALOX5 | C1GALT1C1 | 0.651072 | 4 | 0 | 3 |
| ALOX5 | TNFSF8 | 0.650208 | 4 | 0 | 3 |
| ALOX5 | HCST | 0.649817 | 6 | 0 | 6 |
For details and further investigation, click here
