| Full name: amyloid beta precursor protein binding family B member 2 | Alias Symbol: FE65L|FE65L1|MGC35575 | ||
| Type: protein-coding gene | Cytoband: 4p14-p13 | ||
| Entrez ID: 323 | HGNC ID: HGNC:582 | Ensembl Gene: ENSG00000163697 | OMIM ID: 602710 |
| Drug and gene relationship at DGIdb | |||
Expression of APBB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APBB2 | 323 | 212985_at | 0.4320 | 0.5709 | |
| GSE20347 | APBB2 | 323 | 212970_at | 0.2972 | 0.0322 | |
| GSE23400 | APBB2 | 323 | 212970_at | 0.0169 | 0.8030 | |
| GSE26886 | APBB2 | 323 | 212970_at | 0.7662 | 0.0032 | |
| GSE29001 | APBB2 | 323 | 212970_at | 0.4717 | 0.0513 | |
| GSE38129 | APBB2 | 323 | 212970_at | -0.0700 | 0.7515 | |
| GSE45670 | APBB2 | 323 | 212985_at | -0.2523 | 0.5131 | |
| GSE53622 | APBB2 | 323 | 20245 | 0.4157 | 0.0013 | |
| GSE53624 | APBB2 | 323 | 147803 | 0.2920 | 0.0044 | |
| GSE63941 | APBB2 | 323 | 212985_at | -1.2745 | 0.0894 | |
| GSE77861 | APBB2 | 323 | 216747_at | -0.0945 | 0.2592 | |
| GSE97050 | APBB2 | 323 | A_33_P3251901 | -0.4485 | 0.2029 | |
| SRP007169 | APBB2 | 323 | RNAseq | 1.6119 | 0.0003 | |
| SRP008496 | APBB2 | 323 | RNAseq | 1.9725 | 0.0000 | |
| SRP064894 | APBB2 | 323 | RNAseq | 0.9933 | 0.0000 | |
| SRP133303 | APBB2 | 323 | RNAseq | 0.7332 | 0.0066 | |
| SRP159526 | APBB2 | 323 | RNAseq | 0.6327 | 0.0862 | |
| SRP193095 | APBB2 | 323 | RNAseq | 0.8927 | 0.0000 | |
| SRP219564 | APBB2 | 323 | RNAseq | 0.5456 | 0.1889 | |
| TCGA | APBB2 | 323 | RNAseq | -0.2187 | 0.0021 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by APBB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APBB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APBB2 | 323 | 1 | 17 | 12 | |
| GSE20123 | APBB2 | 323 | 1 | 17 | 12 | |
| GSE43470 | APBB2 | 323 | 0 | 14 | 29 | |
| GSE46452 | APBB2 | 323 | 1 | 36 | 22 | |
| GSE47630 | APBB2 | 323 | 1 | 19 | 20 | |
| GSE54993 | APBB2 | 323 | 7 | 0 | 63 | |
| GSE54994 | APBB2 | 323 | 4 | 10 | 39 | |
| GSE60625 | APBB2 | 323 | 0 | 0 | 11 | |
| GSE74703 | APBB2 | 323 | 0 | 12 | 24 | |
| GSE74704 | APBB2 | 323 | 0 | 10 | 10 | |
| TCGA | APBB2 | 323 | 10 | 44 | 42 |
Total number of gains: 25; Total number of losses: 179; Total Number of normals: 284.
Somatic mutations of APBB2:
Generating mutation plots.
Highly correlated genes for APBB2:
Showing top 20/310 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APBB2 | ANTXR2 | 0.785301 | 3 | 0 | 3 |
| APBB2 | HES6 | 0.732813 | 3 | 0 | 3 |
| APBB2 | LIMS2 | 0.731194 | 4 | 0 | 4 |
| APBB2 | ITGA7 | 0.713503 | 3 | 0 | 3 |
| APBB2 | PYGM | 0.707542 | 3 | 0 | 3 |
| APBB2 | STX2 | 0.707396 | 10 | 0 | 10 |
| APBB2 | FSD1L | 0.699773 | 4 | 0 | 4 |
| APBB2 | NFIC | 0.69606 | 3 | 0 | 3 |
| APBB2 | VAX2 | 0.694679 | 3 | 0 | 3 |
| APBB2 | GUCY1A2 | 0.692747 | 3 | 0 | 3 |
| APBB2 | DLC1 | 0.682183 | 5 | 0 | 5 |
| APBB2 | PLA2G5 | 0.677308 | 3 | 0 | 3 |
| APBB2 | BNC2 | 0.674015 | 4 | 0 | 3 |
| APBB2 | FLNC | 0.672964 | 4 | 0 | 3 |
| APBB2 | CASQ2 | 0.672018 | 3 | 0 | 3 |
| APBB2 | NRXN3 | 0.668715 | 4 | 0 | 3 |
| APBB2 | GPC4 | 0.667164 | 6 | 0 | 4 |
| APBB2 | MITF | 0.664851 | 4 | 0 | 4 |
| APBB2 | PPARGC1A | 0.662807 | 3 | 0 | 3 |
| APBB2 | MRPL32 | 0.662482 | 3 | 0 | 3 |
For details and further investigation, click here
