| Full name: transducer of ERBB2, 1 | Alias Symbol: TOB|TROB|APRO5 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 10140 | HGNC ID: HGNC:11979 | Ensembl Gene: ENSG00000141232 | OMIM ID: 605523 |
| Drug and gene relationship at DGIdb | |||
Expression of TOB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOB1 | 10140 | 202704_at | -1.0781 | 0.0090 | |
| GSE20347 | TOB1 | 10140 | 202704_at | -0.9992 | 0.0001 | |
| GSE23400 | TOB1 | 10140 | 202704_at | -1.0894 | 0.0000 | |
| GSE29001 | TOB1 | 10140 | 202704_at | -0.9594 | 0.0003 | |
| GSE38129 | TOB1 | 10140 | 202704_at | -1.0410 | 0.0000 | |
| GSE45670 | TOB1 | 10140 | 202704_at | -0.5564 | 0.0007 | |
| GSE53622 | TOB1 | 10140 | 24830 | -1.0198 | 0.0000 | |
| GSE53624 | TOB1 | 10140 | 24830 | -1.1619 | 0.0000 | |
| GSE63941 | TOB1 | 10140 | 202704_at | -0.5819 | 0.1065 | |
| GSE77861 | TOB1 | 10140 | 202704_at | -0.7162 | 0.0472 | |
| GSE97050 | TOB1 | 10140 | A_23_P164179 | -1.1886 | 0.0762 | |
| SRP007169 | TOB1 | 10140 | RNAseq | -2.2885 | 0.0000 | |
| SRP008496 | TOB1 | 10140 | RNAseq | -2.2285 | 0.0000 | |
| SRP064894 | TOB1 | 10140 | RNAseq | -1.5052 | 0.0000 | |
| SRP133303 | TOB1 | 10140 | RNAseq | -0.9414 | 0.0000 | |
| SRP159526 | TOB1 | 10140 | RNAseq | -1.2736 | 0.0000 | |
| SRP193095 | TOB1 | 10140 | RNAseq | -0.9849 | 0.0000 | |
| SRP219564 | TOB1 | 10140 | RNAseq | -0.7046 | 0.2009 | |
| TCGA | TOB1 | 10140 | RNAseq | -0.2904 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by TOB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOB1 | 10140 | 5 | 2 | 23 | |
| GSE20123 | TOB1 | 10140 | 5 | 2 | 23 | |
| GSE43470 | TOB1 | 10140 | 3 | 2 | 38 | |
| GSE46452 | TOB1 | 10140 | 32 | 0 | 27 | |
| GSE47630 | TOB1 | 10140 | 9 | 0 | 31 | |
| GSE54993 | TOB1 | 10140 | 2 | 4 | 64 | |
| GSE54994 | TOB1 | 10140 | 8 | 6 | 39 | |
| GSE60625 | TOB1 | 10140 | 4 | 0 | 7 | |
| GSE74703 | TOB1 | 10140 | 3 | 2 | 31 | |
| GSE74704 | TOB1 | 10140 | 4 | 1 | 15 | |
| TCGA | TOB1 | 10140 | 26 | 8 | 62 |
Total number of gains: 101; Total number of losses: 27; Total Number of normals: 360.
Somatic mutations of TOB1:
Generating mutation plots.
Highly correlated genes for TOB1:
Showing top 20/1436 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOB1 | SMDT1 | 0.795123 | 3 | 0 | 3 |
| TOB1 | SMIM5 | 0.782391 | 5 | 0 | 5 |
| TOB1 | APOBEC1 | 0.76957 | 4 | 0 | 4 |
| TOB1 | KAT2B | 0.74906 | 11 | 0 | 11 |
| TOB1 | SH3BGRL2 | 0.748695 | 6 | 0 | 6 |
| TOB1 | KCTD6 | 0.744024 | 6 | 0 | 6 |
| TOB1 | HPGD | 0.741881 | 10 | 0 | 10 |
| TOB1 | ATF7 | 0.737793 | 3 | 0 | 3 |
| TOB1 | EIF4E3 | 0.735531 | 6 | 0 | 6 |
| TOB1 | NUCB2 | 0.735258 | 10 | 0 | 10 |
| TOB1 | GBP6 | 0.733623 | 3 | 0 | 3 |
| TOB1 | GPD1L | 0.732596 | 10 | 0 | 10 |
| TOB1 | MRPS36 | 0.731188 | 6 | 0 | 6 |
| TOB1 | CYSRT1 | 0.73085 | 5 | 0 | 5 |
| TOB1 | LMBRD1 | 0.726892 | 10 | 0 | 10 |
| TOB1 | FCHO2 | 0.726018 | 7 | 0 | 6 |
| TOB1 | KANK1 | 0.725468 | 10 | 0 | 10 |
| TOB1 | SECISBP2L | 0.722014 | 11 | 0 | 11 |
| TOB1 | CGNL1 | 0.718574 | 6 | 0 | 6 |
| TOB1 | RSPH3 | 0.718012 | 4 | 0 | 4 |
For details and further investigation, click here
