| Full name: apolipoprotein C1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 341 | HGNC ID: HGNC:607 | Ensembl Gene: ENSG00000130208 | OMIM ID: 107710 |
| Drug and gene relationship at DGIdb | |||
Expression of APOC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOC1 | 341 | 204416_x_at | 2.1572 | 0.0494 | |
| GSE20347 | APOC1 | 341 | 213553_x_at | 0.8478 | 0.0000 | |
| GSE23400 | APOC1 | 341 | 213553_x_at | 0.4928 | 0.0000 | |
| GSE26886 | APOC1 | 341 | 213553_x_at | 0.7067 | 0.0003 | |
| GSE29001 | APOC1 | 341 | 204416_x_at | 1.4670 | 0.0017 | |
| GSE38129 | APOC1 | 341 | 213553_x_at | 0.9972 | 0.0000 | |
| GSE45670 | APOC1 | 341 | 213553_x_at | 0.2936 | 0.0320 | |
| GSE53622 | APOC1 | 341 | 92232 | 3.6349 | 0.0000 | |
| GSE53624 | APOC1 | 341 | 92232 | 3.6305 | 0.0000 | |
| GSE63941 | APOC1 | 341 | 213553_x_at | 0.5105 | 0.1397 | |
| GSE77861 | APOC1 | 341 | 213553_x_at | 0.5358 | 0.0772 | |
| GSE97050 | APOC1 | 341 | A_24_P109214 | 1.6096 | 0.0772 | |
| SRP008496 | APOC1 | 341 | RNAseq | 3.1020 | 0.0000 | |
| SRP064894 | APOC1 | 341 | RNAseq | 4.9291 | 0.0000 | |
| SRP133303 | APOC1 | 341 | RNAseq | 4.3164 | 0.0000 | |
| SRP159526 | APOC1 | 341 | RNAseq | 2.8880 | 0.0009 | |
| SRP193095 | APOC1 | 341 | RNAseq | 2.0270 | 0.0000 | |
| SRP219564 | APOC1 | 341 | RNAseq | 4.9171 | 0.0000 | |
| TCGA | APOC1 | 341 | RNAseq | 1.5595 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by APOC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOC1 | 341 | 4 | 5 | 21 | |
| GSE20123 | APOC1 | 341 | 4 | 4 | 22 | |
| GSE43470 | APOC1 | 341 | 3 | 11 | 29 | |
| GSE46452 | APOC1 | 341 | 45 | 1 | 13 | |
| GSE47630 | APOC1 | 341 | 8 | 6 | 26 | |
| GSE54993 | APOC1 | 341 | 17 | 4 | 49 | |
| GSE54994 | APOC1 | 341 | 6 | 12 | 35 | |
| GSE60625 | APOC1 | 341 | 9 | 0 | 2 | |
| GSE74703 | APOC1 | 341 | 3 | 7 | 26 | |
| GSE74704 | APOC1 | 341 | 4 | 2 | 14 | |
| TCGA | APOC1 | 341 | 14 | 17 | 65 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of APOC1:
Generating mutation plots.
Highly correlated genes for APOC1:
Showing top 20/1300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOC1 | APOE | 0.779106 | 12 | 0 | 12 |
| APOC1 | PDIA5 | 0.776027 | 3 | 0 | 3 |
| APOC1 | MTHFD1L | 0.773372 | 3 | 0 | 3 |
| APOC1 | C1QTNF6 | 0.766557 | 4 | 0 | 4 |
| APOC1 | TANGO2 | 0.763413 | 3 | 0 | 3 |
| APOC1 | PLA2G7 | 0.754227 | 12 | 0 | 11 |
| APOC1 | CMTM3 | 0.742599 | 5 | 0 | 5 |
| APOC1 | GTSE1 | 0.734484 | 10 | 0 | 10 |
| APOC1 | RNF2 | 0.727561 | 4 | 0 | 4 |
| APOC1 | NEU1 | 0.725357 | 5 | 0 | 5 |
| APOC1 | ST20 | 0.722039 | 3 | 0 | 3 |
| APOC1 | CTHRC1 | 0.721612 | 8 | 0 | 6 |
| APOC1 | IL4I1 | 0.718511 | 7 | 0 | 7 |
| APOC1 | GORAB | 0.717796 | 4 | 0 | 4 |
| APOC1 | SLC19A1 | 0.717513 | 3 | 0 | 3 |
| APOC1 | WDR66 | 0.712907 | 5 | 0 | 5 |
| APOC1 | SNAP47 | 0.706865 | 3 | 0 | 3 |
| APOC1 | AMIGO2 | 0.706525 | 4 | 0 | 4 |
| APOC1 | NOP56 | 0.705423 | 3 | 0 | 3 |
| APOC1 | PYCR2 | 0.705276 | 3 | 0 | 3 |
For details and further investigation, click here
