| Full name: apolipoprotein E | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 348 | HGNC ID: HGNC:613 | Ensembl Gene: ENSG00000130203 | OMIM ID: 107741 |
| Drug and gene relationship at DGIdb | |||
APOE involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05010 | Alzheimer's disease |
Expression of APOE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOE | 348 | 203381_s_at | 1.3401 | 0.1037 | |
| GSE20347 | APOE | 348 | 212884_x_at | 0.4801 | 0.0000 | |
| GSE23400 | APOE | 348 | 212884_x_at | 0.5965 | 0.0000 | |
| GSE26886 | APOE | 348 | 212884_x_at | 0.8589 | 0.0005 | |
| GSE29001 | APOE | 348 | 212884_x_at | 0.7675 | 0.0008 | |
| GSE38129 | APOE | 348 | 212884_x_at | 0.4090 | 0.0011 | |
| GSE45670 | APOE | 348 | 212884_x_at | 0.0512 | 0.7511 | |
| GSE53622 | APOE | 348 | 9937 | 2.0575 | 0.0000 | |
| GSE53624 | APOE | 348 | 9937 | 2.2363 | 0.0000 | |
| GSE63941 | APOE | 348 | 203381_s_at | 0.3542 | 0.7753 | |
| GSE77861 | APOE | 348 | 212884_x_at | 0.1611 | 0.2225 | |
| GSE97050 | APOE | 348 | A_33_P3223592 | 1.1777 | 0.1204 | |
| SRP008496 | APOE | 348 | RNAseq | 4.7016 | 0.0000 | |
| SRP064894 | APOE | 348 | RNAseq | 3.3730 | 0.0000 | |
| SRP133303 | APOE | 348 | RNAseq | 2.3732 | 0.0000 | |
| SRP159526 | APOE | 348 | RNAseq | 1.9722 | 0.0056 | |
| SRP193095 | APOE | 348 | RNAseq | 1.7939 | 0.0000 | |
| SRP219564 | APOE | 348 | RNAseq | 3.4056 | 0.0000 | |
| TCGA | APOE | 348 | RNAseq | 0.7558 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by APOE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOE | 348 | 4 | 5 | 21 | |
| GSE20123 | APOE | 348 | 4 | 4 | 22 | |
| GSE43470 | APOE | 348 | 3 | 11 | 29 | |
| GSE46452 | APOE | 348 | 45 | 1 | 13 | |
| GSE47630 | APOE | 348 | 8 | 6 | 26 | |
| GSE54993 | APOE | 348 | 17 | 4 | 49 | |
| GSE54994 | APOE | 348 | 6 | 12 | 35 | |
| GSE60625 | APOE | 348 | 9 | 0 | 2 | |
| GSE74703 | APOE | 348 | 3 | 7 | 26 | |
| GSE74704 | APOE | 348 | 4 | 2 | 14 | |
| TCGA | APOE | 348 | 14 | 17 | 65 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of APOE:
Generating mutation plots.
Highly correlated genes for APOE:
Showing top 20/1443 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOE | PDIA5 | 0.789668 | 3 | 0 | 3 |
| APOE | APOC1 | 0.779106 | 12 | 0 | 12 |
| APOE | ZAP70 | 0.744673 | 3 | 0 | 3 |
| APOE | PLA2G7 | 0.74168 | 12 | 0 | 12 |
| APOE | TTC38 | 0.736544 | 3 | 0 | 3 |
| APOE | CRELD2 | 0.733586 | 3 | 0 | 3 |
| APOE | GORAB | 0.723088 | 4 | 0 | 4 |
| APOE | ZNF628 | 0.709576 | 3 | 0 | 3 |
| APOE | C4orf48 | 0.709103 | 6 | 0 | 6 |
| APOE | FCGR3A | 0.705219 | 3 | 0 | 3 |
| APOE | SH3PXD2B | 0.704296 | 6 | 0 | 6 |
| APOE | LRRC8C | 0.703859 | 3 | 0 | 3 |
| APOE | UBE2C | 0.702748 | 8 | 0 | 8 |
| APOE | RELT | 0.700857 | 4 | 0 | 4 |
| APOE | PARP14 | 0.699971 | 4 | 0 | 4 |
| APOE | PYCR2 | 0.697496 | 3 | 0 | 3 |
| APOE | TMEM138 | 0.693879 | 4 | 0 | 4 |
| APOE | EXT1 | 0.693605 | 7 | 0 | 6 |
| APOE | FMNL3 | 0.688394 | 6 | 0 | 6 |
| APOE | IL4I1 | 0.688166 | 8 | 0 | 7 |
For details and further investigation, click here
