| Full name: apolipoprotein L2 | Alias Symbol: APOL-II | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 23780 | HGNC ID: HGNC:619 | Ensembl Gene: ENSG00000128335 | OMIM ID: 607252 |
| Drug and gene relationship at DGIdb | |||
Expression of APOL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOL2 | 23780 | 221653_x_at | 0.2824 | 0.6676 | |
| GSE20347 | APOL2 | 23780 | 221013_s_at | 0.0722 | 0.5116 | |
| GSE23400 | APOL2 | 23780 | 221653_x_at | 0.5356 | 0.0000 | |
| GSE26886 | APOL2 | 23780 | 221013_s_at | 0.3474 | 0.0515 | |
| GSE29001 | APOL2 | 23780 | 221013_s_at | 0.5831 | 0.0135 | |
| GSE38129 | APOL2 | 23780 | 221653_x_at | 0.4805 | 0.0074 | |
| GSE45670 | APOL2 | 23780 | 221653_x_at | 0.9972 | 0.0000 | |
| GSE53622 | APOL2 | 23780 | 3199 | 0.8120 | 0.0000 | |
| GSE53624 | APOL2 | 23780 | 3199 | 0.9592 | 0.0000 | |
| GSE63941 | APOL2 | 23780 | 221653_x_at | -0.4643 | 0.4991 | |
| GSE77861 | APOL2 | 23780 | 221013_s_at | 0.0361 | 0.8769 | |
| GSE97050 | APOL2 | 23780 | A_24_P48898 | 0.3521 | 0.3370 | |
| SRP007169 | APOL2 | 23780 | RNAseq | 2.1125 | 0.0000 | |
| SRP008496 | APOL2 | 23780 | RNAseq | 1.5725 | 0.0000 | |
| SRP064894 | APOL2 | 23780 | RNAseq | 2.0452 | 0.0000 | |
| SRP133303 | APOL2 | 23780 | RNAseq | 1.0685 | 0.0000 | |
| SRP159526 | APOL2 | 23780 | RNAseq | 0.8375 | 0.0026 | |
| SRP193095 | APOL2 | 23780 | RNAseq | 0.6551 | 0.0112 | |
| SRP219564 | APOL2 | 23780 | RNAseq | 2.0425 | 0.0004 | |
| TCGA | APOL2 | 23780 | RNAseq | 0.0392 | 0.6569 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by APOL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOL2 | 23780 | 6 | 6 | 18 | |
| GSE20123 | APOL2 | 23780 | 6 | 5 | 19 | |
| GSE43470 | APOL2 | 23780 | 4 | 6 | 33 | |
| GSE46452 | APOL2 | 23780 | 31 | 1 | 27 | |
| GSE47630 | APOL2 | 23780 | 8 | 5 | 27 | |
| GSE54993 | APOL2 | 23780 | 3 | 6 | 61 | |
| GSE54994 | APOL2 | 23780 | 9 | 9 | 35 | |
| GSE60625 | APOL2 | 23780 | 5 | 0 | 6 | |
| GSE74703 | APOL2 | 23780 | 4 | 4 | 28 | |
| GSE74704 | APOL2 | 23780 | 3 | 2 | 15 | |
| TCGA | APOL2 | 23780 | 27 | 15 | 54 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of APOL2:
Generating mutation plots.
Highly correlated genes for APOL2:
Showing top 20/635 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOL2 | CYHR1 | 0.761639 | 3 | 0 | 3 |
| APOL2 | APOL1 | 0.740082 | 12 | 0 | 10 |
| APOL2 | USP41 | 0.739454 | 3 | 0 | 3 |
| APOL2 | HPN | 0.704421 | 4 | 0 | 4 |
| APOL2 | HGF | 0.701484 | 4 | 0 | 4 |
| APOL2 | RASAL3 | 0.700852 | 4 | 0 | 4 |
| APOL2 | TNRC6C-AS1 | 0.699085 | 3 | 0 | 3 |
| APOL2 | SNAPC2 | 0.696691 | 3 | 0 | 3 |
| APOL2 | FERMT3 | 0.686935 | 3 | 0 | 3 |
| APOL2 | NLRC5 | 0.685244 | 5 | 0 | 5 |
| APOL2 | SYN1 | 0.678521 | 3 | 0 | 3 |
| APOL2 | SP140 | 0.678186 | 3 | 0 | 3 |
| APOL2 | PPP1R37 | 0.676953 | 4 | 0 | 4 |
| APOL2 | C1QC | 0.671068 | 4 | 0 | 3 |
| APOL2 | HLA-F | 0.667548 | 8 | 0 | 7 |
| APOL2 | PSMB10 | 0.663747 | 8 | 0 | 7 |
| APOL2 | IFI35 | 0.663278 | 9 | 0 | 7 |
| APOL2 | DDX60L | 0.660188 | 5 | 0 | 5 |
| APOL2 | C1QB | 0.659692 | 6 | 0 | 4 |
| APOL2 | EME1 | 0.659034 | 3 | 0 | 3 |
For details and further investigation, click here
