| Full name: apolipoprotein L1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 8542 | HGNC ID: HGNC:618 | Ensembl Gene: ENSG00000100342 | OMIM ID: 603743 |
| Drug and gene relationship at DGIdb | |||
Expression of APOL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOL1 | 8542 | 209546_s_at | 1.1216 | 0.1438 | |
| GSE20347 | APOL1 | 8542 | 209546_s_at | 1.1220 | 0.0010 | |
| GSE23400 | APOL1 | 8542 | 209546_s_at | 0.9834 | 0.0000 | |
| GSE26886 | APOL1 | 8542 | 209546_s_at | 0.3376 | 0.4210 | |
| GSE29001 | APOL1 | 8542 | 209546_s_at | 1.5048 | 0.0000 | |
| GSE38129 | APOL1 | 8542 | 209546_s_at | 1.0182 | 0.0001 | |
| GSE45670 | APOL1 | 8542 | 209546_s_at | 1.6671 | 0.0000 | |
| GSE53622 | APOL1 | 8542 | 23367 | 0.8399 | 0.0000 | |
| GSE53624 | APOL1 | 8542 | 23367 | 0.5360 | 0.0000 | |
| GSE63941 | APOL1 | 8542 | 209546_s_at | -1.2337 | 0.1817 | |
| GSE77861 | APOL1 | 8542 | 209546_s_at | 0.3683 | 0.3595 | |
| GSE97050 | APOL1 | 8542 | A_24_P87931 | 0.6255 | 0.1163 | |
| SRP007169 | APOL1 | 8542 | RNAseq | 2.9674 | 0.0000 | |
| SRP008496 | APOL1 | 8542 | RNAseq | 1.6704 | 0.0006 | |
| SRP064894 | APOL1 | 8542 | RNAseq | 2.4760 | 0.0000 | |
| SRP133303 | APOL1 | 8542 | RNAseq | 1.7141 | 0.0000 | |
| SRP159526 | APOL1 | 8542 | RNAseq | 0.9923 | 0.1224 | |
| SRP193095 | APOL1 | 8542 | RNAseq | 1.1004 | 0.0022 | |
| SRP219564 | APOL1 | 8542 | RNAseq | 3.0841 | 0.0000 | |
| TCGA | APOL1 | 8542 | RNAseq | 0.1569 | 0.2036 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by APOL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOL1 | 8542 | 6 | 6 | 18 | |
| GSE20123 | APOL1 | 8542 | 6 | 5 | 19 | |
| GSE43470 | APOL1 | 8542 | 4 | 6 | 33 | |
| GSE46452 | APOL1 | 8542 | 31 | 1 | 27 | |
| GSE47630 | APOL1 | 8542 | 8 | 5 | 27 | |
| GSE54993 | APOL1 | 8542 | 3 | 6 | 61 | |
| GSE54994 | APOL1 | 8542 | 9 | 9 | 35 | |
| GSE60625 | APOL1 | 8542 | 5 | 0 | 6 | |
| GSE74703 | APOL1 | 8542 | 4 | 4 | 28 | |
| GSE74704 | APOL1 | 8542 | 3 | 2 | 15 | |
| TCGA | APOL1 | 8542 | 27 | 15 | 54 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of APOL1:
Generating mutation plots.
Highly correlated genes for APOL1:
Showing top 20/656 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOL1 | CD300C | 0.748336 | 3 | 0 | 3 |
| APOL1 | APOL2 | 0.740082 | 12 | 0 | 10 |
| APOL1 | SH3PXD2B | 0.665044 | 4 | 0 | 4 |
| APOL1 | CD6 | 0.659363 | 3 | 0 | 3 |
| APOL1 | PDE7A | 0.654878 | 4 | 0 | 4 |
| APOL1 | TAP1 | 0.653354 | 10 | 0 | 9 |
| APOL1 | GZMB | 0.650747 | 9 | 0 | 9 |
| APOL1 | ARPC1B | 0.650392 | 9 | 0 | 8 |
| APOL1 | DCBLD1 | 0.647624 | 6 | 0 | 4 |
| APOL1 | SCO2 | 0.646972 | 8 | 0 | 6 |
| APOL1 | CDCA2 | 0.646392 | 3 | 0 | 3 |
| APOL1 | GBP1 | 0.645689 | 11 | 0 | 9 |
| APOL1 | CXCL16 | 0.642624 | 4 | 0 | 4 |
| APOL1 | PARP14 | 0.639104 | 7 | 0 | 6 |
| APOL1 | MMP12 | 0.637619 | 11 | 0 | 9 |
| APOL1 | GBP2 | 0.637154 | 3 | 0 | 3 |
| APOL1 | IFI35 | 0.635837 | 10 | 0 | 9 |
| APOL1 | PARP12 | 0.633886 | 11 | 0 | 9 |
| APOL1 | ADAM8 | 0.633247 | 9 | 0 | 7 |
| APOL1 | RTP4 | 0.631492 | 11 | 0 | 10 |
For details and further investigation, click here
