CAMK2D

 

Full name: calcium/calmodulin dependent protein kinase II delta Alias Symbol: 
Type: protein-coding gene Cytoband: 4q26
Entrez ID: 817 HGNC ID: HGNC:1462 Ensembl Gene: ENSG00000145349 OMIM ID: 607708
Drug and gene relationship at DGIdb

 

CAMK2D involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04066HIF-1 signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04971Gastric acid secretion
hsa05031Amphetamine addiction
hsa05152Tuberculosis
hsa05205Proteoglycans in cancer
hsa05214Glioma

 

Expression of CAMK2D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CAMK2D 817 225019_at -0.8048 0.1942
GSE26886 CAMK2D 817 225019_at -0.2607 0.3355
GSE45670 CAMK2D 817 225019_at -0.3139 0.0761
GSE53622 CAMK2D 817 73455 -0.6129 0.0000
GSE53624 CAMK2D 817 73455 -0.6591 0.0000
GSE63941 CAMK2D 817 225019_at -1.2967 0.0202
GSE77861 CAMK2D 817 225019_at -0.8040 0.0191
GSE97050 CAMK2D 817 A_23_P144458 0.2341 0.4473
SRP007169 CAMK2D 817 RNAseq -1.2348 0.0003
SRP008496 CAMK2D 817 RNAseq -1.1688 0.0000
SRP064894 CAMK2D 817 RNAseq -0.7086 0.0028
SRP133303 CAMK2D 817 RNAseq 0.0054 0.9741
SRP159526 CAMK2D 817 RNAseq -0.5480 0.0261
SRP193095 CAMK2D 817 RNAseq -0.6166 0.0000
SRP219564 CAMK2D 817 RNAseq -0.3906 0.3453
TCGA CAMK2D 817 RNAseq -0.1893 0.0060

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by CAMK2D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CAMK2D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CAMK2D 817 1 13 16
GSE20123 CAMK2D 817 1 13 16
GSE43470 CAMK2D 817 0 14 29
GSE46452 CAMK2D 817 1 36 22
GSE47630 CAMK2D 817 0 22 18
GSE54993 CAMK2D 817 9 0 61
GSE54994 CAMK2D 817 1 10 42
GSE60625 CAMK2D 817 0 3 8
GSE74703 CAMK2D 817 0 12 24
GSE74704 CAMK2D 817 0 7 13
TCGA CAMK2D 817 8 35 53

Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.  

 

Somatic mutations of CAMK2D:

 

Generating mutation plots.

 

Highly correlated genes for CAMK2D:

 

Showing top 20/771 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CAMK2DSTAMBP0.799286303
CAMK2DLYSMD30.778899303
CAMK2DRNF1110.742374404
CAMK2DSUGT10.735963303
CAMK2DDCTN40.725431303
CAMK2DHERPUD20.720122303
CAMK2DARG20.719056303
CAMK2DKRT33B0.714428303
CAMK2DLRP110.706304303
CAMK2DACTR3C0.698399403
CAMK2DATP6V1C20.696053404
CAMK2DRER10.693738606
CAMK2DEPG50.691393303
CAMK2DTRNAU1AP0.691166404
CAMK2DPRKAB10.689697303
CAMK2DPDCD6IP0.689664505
CAMK2DWDFY10.689162303
CAMK2DTMEM38A0.688371303
CAMK2DPDLIM20.686694605
CAMK2DMAML20.685699504

For details and further investigation, click here