| Full name: interferon regulatory factor 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 3665 | HGNC ID: HGNC:6122 | Ensembl Gene: ENSG00000185507 | OMIM ID: 605047 |
| Drug and gene relationship at DGIdb | |||
IRF7 involved pathways:
Expression of IRF7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF7 | 3665 | 208436_s_at | -0.4625 | 0.6127 | |
| GSE20347 | IRF7 | 3665 | 208436_s_at | 0.3193 | 0.3442 | |
| GSE23400 | IRF7 | 3665 | 208436_s_at | 0.3005 | 0.0218 | |
| GSE26886 | IRF7 | 3665 | 208436_s_at | 1.2627 | 0.0030 | |
| GSE29001 | IRF7 | 3665 | 208436_s_at | 0.4802 | 0.2757 | |
| GSE38129 | IRF7 | 3665 | 208436_s_at | 0.2690 | 0.3032 | |
| GSE45670 | IRF7 | 3665 | 208436_s_at | 1.3797 | 0.0002 | |
| GSE53622 | IRF7 | 3665 | 64422 | 0.3137 | 0.0287 | |
| GSE53624 | IRF7 | 3665 | 64422 | 0.5258 | 0.0000 | |
| GSE63941 | IRF7 | 3665 | 208436_s_at | 0.2634 | 0.8152 | |
| GSE77861 | IRF7 | 3665 | 208436_s_at | 0.2581 | 0.5143 | |
| GSE97050 | IRF7 | 3665 | A_24_P378019 | 0.4656 | 0.2830 | |
| SRP007169 | IRF7 | 3665 | RNAseq | -0.7985 | 0.1877 | |
| SRP008496 | IRF7 | 3665 | RNAseq | -0.8144 | 0.0323 | |
| SRP064894 | IRF7 | 3665 | RNAseq | 0.8196 | 0.0215 | |
| SRP133303 | IRF7 | 3665 | RNAseq | 0.1908 | 0.4359 | |
| SRP159526 | IRF7 | 3665 | RNAseq | -0.9737 | 0.0294 | |
| SRP193095 | IRF7 | 3665 | RNAseq | 0.5458 | 0.0065 | |
| SRP219564 | IRF7 | 3665 | RNAseq | 0.0182 | 0.9719 | |
| TCGA | IRF7 | 3665 | RNAseq | 0.2971 | 0.0170 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IRF7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRF7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF7 | 3665 | 1 | 11 | 18 | |
| GSE20123 | IRF7 | 3665 | 1 | 12 | 17 | |
| GSE43470 | IRF7 | 3665 | 1 | 10 | 32 | |
| GSE46452 | IRF7 | 3665 | 7 | 8 | 44 | |
| GSE47630 | IRF7 | 3665 | 4 | 12 | 24 | |
| GSE54993 | IRF7 | 3665 | 3 | 1 | 66 | |
| GSE54994 | IRF7 | 3665 | 1 | 12 | 40 | |
| GSE60625 | IRF7 | 3665 | 0 | 0 | 11 | |
| GSE74703 | IRF7 | 3665 | 1 | 8 | 27 | |
| GSE74704 | IRF7 | 3665 | 0 | 8 | 12 | |
| TCGA | IRF7 | 3665 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 120; Total Number of normals: 341.
Somatic mutations of IRF7:
Generating mutation plots.
Highly correlated genes for IRF7:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF7 | RNF213 | 0.776614 | 3 | 0 | 3 |
| IRF7 | MX1 | 0.739616 | 10 | 0 | 10 |
| IRF7 | NPFFR1 | 0.730582 | 3 | 0 | 3 |
| IRF7 | HELZ2 | 0.709319 | 5 | 0 | 5 |
| IRF7 | FHL2 | 0.708335 | 3 | 0 | 3 |
| IRF7 | ARF1 | 0.7057 | 3 | 0 | 3 |
| IRF7 | EPSTI1 | 0.704152 | 6 | 0 | 6 |
| IRF7 | BMP2 | 0.693623 | 3 | 0 | 3 |
| IRF7 | SHANK3 | 0.693531 | 3 | 0 | 3 |
| IRF7 | SH3PXD2B | 0.693313 | 3 | 0 | 3 |
| IRF7 | DDX60L | 0.692364 | 5 | 0 | 5 |
| IRF7 | XAF1 | 0.683827 | 11 | 0 | 10 |
| IRF7 | C9orf64 | 0.681276 | 3 | 0 | 3 |
| IRF7 | IQCC | 0.67724 | 3 | 0 | 3 |
| IRF7 | NOP2 | 0.67722 | 3 | 0 | 3 |
| IRF7 | CLMN | 0.672696 | 3 | 0 | 3 |
| IRF7 | SUSD3 | 0.668689 | 3 | 0 | 3 |
| IRF7 | BCORL1 | 0.668451 | 3 | 0 | 3 |
| IRF7 | CMPK2 | 0.66809 | 6 | 0 | 5 |
| IRF7 | THAP6 | 0.663289 | 3 | 0 | 3 |
For details and further investigation, click here
