| Full name: aurora kinase A | Alias Symbol: BTAK|AurA|STK7|ARK1|PPP1R47|AIK | ||
| Type: protein-coding gene | Cytoband: 20q13.2 | ||
| Entrez ID: 6790 | HGNC ID: HGNC:11393 | Ensembl Gene: ENSG00000087586 | OMIM ID: 603072 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
AURKA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis |
Expression of AURKA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AURKA | 6790 | 208079_s_at | 2.0202 | 0.0242 | |
| GSE20347 | AURKA | 6790 | 208079_s_at | 2.1786 | 0.0000 | |
| GSE23400 | AURKA | 6790 | 204092_s_at | 0.8967 | 0.0000 | |
| GSE26886 | AURKA | 6790 | 208079_s_at | 0.8754 | 0.0180 | |
| GSE29001 | AURKA | 6790 | 208079_s_at | 2.0668 | 0.0000 | |
| GSE38129 | AURKA | 6790 | 208079_s_at | 2.4450 | 0.0000 | |
| GSE45670 | AURKA | 6790 | 208079_s_at | 1.7730 | 0.0000 | |
| GSE53622 | AURKA | 6790 | 17953 | 2.3174 | 0.0000 | |
| GSE53624 | AURKA | 6790 | 47668 | 1.4864 | 0.0000 | |
| GSE63941 | AURKA | 6790 | 208079_s_at | 2.1100 | 0.0075 | |
| GSE77861 | AURKA | 6790 | 204092_s_at | 1.0457 | 0.0057 | |
| GSE97050 | AURKA | 6790 | A_23_P131866 | 2.4428 | 0.0620 | |
| SRP007169 | AURKA | 6790 | RNAseq | 2.7190 | 0.0000 | |
| SRP008496 | AURKA | 6790 | RNAseq | 2.0611 | 0.0000 | |
| SRP064894 | AURKA | 6790 | RNAseq | 2.4383 | 0.0000 | |
| SRP133303 | AURKA | 6790 | RNAseq | 2.0965 | 0.0000 | |
| SRP159526 | AURKA | 6790 | RNAseq | 1.7484 | 0.0000 | |
| SRP193095 | AURKA | 6790 | RNAseq | 1.2085 | 0.0000 | |
| SRP219564 | AURKA | 6790 | RNAseq | 1.8552 | 0.0021 | |
| TCGA | AURKA | 6790 | RNAseq | 0.8580 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by AURKA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AURKA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AURKA | 6790 | 14 | 2 | 14 | |
| GSE20123 | AURKA | 6790 | 14 | 2 | 14 | |
| GSE43470 | AURKA | 6790 | 13 | 0 | 30 | |
| GSE46452 | AURKA | 6790 | 29 | 0 | 30 | |
| GSE47630 | AURKA | 6790 | 24 | 1 | 15 | |
| GSE54993 | AURKA | 6790 | 0 | 17 | 53 | |
| GSE54994 | AURKA | 6790 | 27 | 0 | 26 | |
| GSE60625 | AURKA | 6790 | 0 | 0 | 11 | |
| GSE74703 | AURKA | 6790 | 11 | 0 | 25 | |
| GSE74704 | AURKA | 6790 | 11 | 0 | 9 | |
| TCGA | AURKA | 6790 | 43 | 4 | 49 |
Total number of gains: 186; Total number of losses: 26; Total Number of normals: 276.
Somatic mutations of AURKA:
Generating mutation plots.
Highly correlated genes for AURKA:
Showing top 20/2188 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AURKA | UBE2C | 0.892002 | 13 | 0 | 13 |
| AURKA | KIF18B | 0.855558 | 10 | 0 | 10 |
| AURKA | TOP2A | 0.851696 | 13 | 0 | 13 |
| AURKA | KIF20A | 0.847183 | 13 | 0 | 13 |
| AURKA | TPX2 | 0.847115 | 13 | 0 | 13 |
| AURKA | GINS1 | 0.839978 | 12 | 0 | 12 |
| AURKA | NEK2 | 0.835026 | 13 | 0 | 13 |
| AURKA | CDKN3 | 0.833528 | 13 | 0 | 13 |
| AURKA | KIF14 | 0.828979 | 13 | 0 | 12 |
| AURKA | CDCA2 | 0.826493 | 7 | 0 | 6 |
| AURKA | TRIP13 | 0.822104 | 13 | 0 | 13 |
| AURKA | NUF2 | 0.820442 | 9 | 0 | 9 |
| AURKA | MYBL2 | 0.818629 | 12 | 0 | 12 |
| AURKA | KPNA2 | 0.814837 | 10 | 0 | 10 |
| AURKA | CCNB2 | 0.812824 | 12 | 0 | 12 |
| AURKA | CEP55 | 0.812613 | 13 | 0 | 13 |
| AURKA | CDC20 | 0.807986 | 12 | 0 | 11 |
| AURKA | NCAPH | 0.805421 | 9 | 0 | 9 |
| AURKA | MRGBP | 0.801513 | 11 | 0 | 11 |
| AURKA | KIF2C | 0.800896 | 13 | 0 | 12 |
For details and further investigation, click here
