| Full name: Rho guanine nucleotide exchange factor 4 | Alias Symbol: STM6|KIAA1112|ASEF | ||
| Type: protein-coding gene | Cytoband: 2q21.1 | ||
| Entrez ID: 50649 | HGNC ID: HGNC:684 | Ensembl Gene: ENSG00000136002 | OMIM ID: 605216 |
| Drug and gene relationship at DGIdb | |||
ARHGEF4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ARHGEF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF4 | 50649 | 205109_s_at | -0.1516 | 0.8832 | |
| GSE20347 | ARHGEF4 | 50649 | 205109_s_at | -0.0875 | 0.8111 | |
| GSE23400 | ARHGEF4 | 50649 | 205109_s_at | 0.1485 | 0.3464 | |
| GSE26886 | ARHGEF4 | 50649 | 205109_s_at | -0.0376 | 0.9197 | |
| GSE29001 | ARHGEF4 | 50649 | 205109_s_at | -0.2889 | 0.5813 | |
| GSE38129 | ARHGEF4 | 50649 | 205109_s_at | 0.0745 | 0.8207 | |
| GSE45670 | ARHGEF4 | 50649 | 205109_s_at | 0.4684 | 0.0165 | |
| GSE53622 | ARHGEF4 | 50649 | 12033 | -0.7437 | 0.0000 | |
| GSE53624 | ARHGEF4 | 50649 | 12033 | -0.4574 | 0.0000 | |
| GSE63941 | ARHGEF4 | 50649 | 205109_s_at | 1.0166 | 0.2411 | |
| GSE77861 | ARHGEF4 | 50649 | 205109_s_at | 0.6483 | 0.0602 | |
| GSE97050 | ARHGEF4 | 50649 | A_24_P302685 | -0.2470 | 0.5868 | |
| SRP007169 | ARHGEF4 | 50649 | RNAseq | -0.6323 | 0.0773 | |
| SRP008496 | ARHGEF4 | 50649 | RNAseq | -0.2589 | 0.3202 | |
| SRP064894 | ARHGEF4 | 50649 | RNAseq | -0.4267 | 0.2042 | |
| SRP133303 | ARHGEF4 | 50649 | RNAseq | -0.3918 | 0.1979 | |
| SRP159526 | ARHGEF4 | 50649 | RNAseq | -0.4311 | 0.4018 | |
| SRP193095 | ARHGEF4 | 50649 | RNAseq | -0.0745 | 0.8443 | |
| SRP219564 | ARHGEF4 | 50649 | RNAseq | -0.5228 | 0.3335 | |
| TCGA | ARHGEF4 | 50649 | RNAseq | 0.7200 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF4 | 50649 | 5 | 3 | 22 | |
| GSE20123 | ARHGEF4 | 50649 | 5 | 3 | 22 | |
| GSE43470 | ARHGEF4 | 50649 | 2 | 2 | 39 | |
| GSE46452 | ARHGEF4 | 50649 | 1 | 3 | 55 | |
| GSE47630 | ARHGEF4 | 50649 | 5 | 0 | 35 | |
| GSE54993 | ARHGEF4 | 50649 | 0 | 6 | 64 | |
| GSE54994 | ARHGEF4 | 50649 | 10 | 0 | 43 | |
| GSE60625 | ARHGEF4 | 50649 | 0 | 3 | 8 | |
| GSE74703 | ARHGEF4 | 50649 | 2 | 1 | 33 | |
| GSE74704 | ARHGEF4 | 50649 | 3 | 1 | 16 | |
| TCGA | ARHGEF4 | 50649 | 22 | 9 | 65 |
Total number of gains: 55; Total number of losses: 31; Total Number of normals: 402.
Somatic mutations of ARHGEF4:
Generating mutation plots.
Highly correlated genes for ARHGEF4:
Showing top 20/53 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF4 | B4GALNT3 | 0.627658 | 3 | 0 | 3 |
| ARHGEF4 | C10orf99 | 0.620246 | 3 | 0 | 3 |
| ARHGEF4 | FAM83G | 0.615574 | 4 | 0 | 3 |
| ARHGEF4 | NEB | 0.595399 | 3 | 0 | 3 |
| ARHGEF4 | METRNL | 0.595141 | 3 | 0 | 3 |
| ARHGEF4 | EFR3B | 0.585996 | 4 | 0 | 3 |
| ARHGEF4 | FUT8-AS1 | 0.583718 | 3 | 0 | 3 |
| ARHGEF4 | RUSC1-AS1 | 0.571905 | 3 | 0 | 3 |
| ARHGEF4 | TUBA4A | 0.570885 | 8 | 0 | 5 |
| ARHGEF4 | AIG1 | 0.568558 | 3 | 0 | 3 |
| ARHGEF4 | ATL2 | 0.566378 | 4 | 0 | 3 |
| ARHGEF4 | MAST4 | 0.56518 | 5 | 0 | 3 |
| ARHGEF4 | WDR59 | 0.563685 | 3 | 0 | 3 |
| ARHGEF4 | BICD2 | 0.562668 | 10 | 0 | 6 |
| ARHGEF4 | NUP35 | 0.557193 | 3 | 0 | 3 |
| ARHGEF4 | GJB6 | 0.55651 | 5 | 0 | 4 |
| ARHGEF4 | PLD2 | 0.552982 | 5 | 0 | 4 |
| ARHGEF4 | AHNAK2 | 0.547861 | 9 | 0 | 6 |
| ARHGEF4 | SDR9C7 | 0.545836 | 4 | 0 | 3 |
| ARHGEF4 | HSPB1 | 0.545521 | 8 | 0 | 5 |
For details and further investigation, click here
