TUBA4A

 

Full name: tubulin alpha 4a Alias Symbol: FLJ30169|H2-ALPHA
Type: protein-coding gene Cytoband: 2q35
Entrez ID: 7277 HGNC ID: HGNC:12407 Ensembl Gene: ENSG00000127824 OMIM ID: 191110
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TUBA4A involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa05130Pathogenic Escherichia coli infection

 

Expression of TUBA4A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TUBA4A 7277 212242_at -0.2071 0.8881
GSE20347 TUBA4A 7277 212242_at -0.3964 0.1078
GSE23400 TUBA4A 7277 212242_at 0.1858 0.1980
GSE26886 TUBA4A 7277 212242_at -0.6194 0.1076
GSE29001 TUBA4A 7277 212242_at -0.2975 0.5364
GSE38129 TUBA4A 7277 212242_at -0.0717 0.8124
GSE45670 TUBA4A 7277 212242_at 0.5916 0.0062
GSE53622 TUBA4A 7277 9362 -0.2629 0.0547
GSE53624 TUBA4A 7277 9362 0.0055 0.9498
GSE63941 TUBA4A 7277 212242_at 0.6889 0.3980
GSE77861 TUBA4A 7277 212242_at 0.5962 0.0601
GSE97050 TUBA4A 7277 A_23_P102109 0.3064 0.2537
SRP007169 TUBA4A 7277 RNAseq -0.9268 0.0889
SRP008496 TUBA4A 7277 RNAseq -0.7901 0.0137
SRP064894 TUBA4A 7277 RNAseq 0.1281 0.7245
SRP133303 TUBA4A 7277 RNAseq 0.2939 0.3029
SRP159526 TUBA4A 7277 RNAseq -0.5461 0.3146
SRP193095 TUBA4A 7277 RNAseq -0.2374 0.2537
SRP219564 TUBA4A 7277 RNAseq -0.5344 0.1787
TCGA TUBA4A 7277 RNAseq 0.3324 0.0009

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TUBA4A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TUBA4A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TUBA4A 7277 2 14 14
GSE20123 TUBA4A 7277 2 13 15
GSE43470 TUBA4A 7277 1 7 35
GSE46452 TUBA4A 7277 0 5 54
GSE47630 TUBA4A 7277 4 5 31
GSE54993 TUBA4A 7277 1 2 67
GSE54994 TUBA4A 7277 8 9 36
GSE60625 TUBA4A 7277 0 3 8
GSE74703 TUBA4A 7277 1 5 30
GSE74704 TUBA4A 7277 2 7 11
TCGA TUBA4A 7277 12 26 58

Total number of gains: 33; Total number of losses: 96; Total Number of normals: 359.  

 

Somatic mutations of TUBA4A:

 

Generating mutation plots.

 

Highly correlated genes for TUBA4A:

 

Showing top 20/345 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TUBA4ASTARD40.72421303
TUBA4ATUBA4B0.709744908
TUBA4AKRT6A0.6922651009
TUBA4ASDK20.686006303
TUBA4AKLC30.685774303
TUBA4ASFN0.68346612010
TUBA4AFOXN3-AS10.676721303
TUBA4AUPP10.6748341009
TUBA4AYWHAQ0.673311303
TUBA4AIL20RB0.666361604
TUBA4AKRT6C0.664958403
TUBA4AKRT6B0.66269412010
TUBA4AFAM83G0.654258706
TUBA4ADMKN0.652198604
TUBA4AGJB60.651574606
TUBA4AKRT160.64723713011
TUBA4AGPX20.646443303
TUBA4ASIRPA0.639437303
TUBA4AFABP50.63774412010
TUBA4AFAM83C0.637631504

For details and further investigation, click here