| Full name: vesicle associated membrane protein 8 | Alias Symbol: EDB | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 8673 | HGNC ID: HGNC:12647 | Ensembl Gene: ENSG00000118640 | OMIM ID: 603177 |
| Drug and gene relationship at DGIdb | |||
Expression of VAMP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VAMP8 | 8673 | 202546_at | -0.4287 | 0.5548 | |
| GSE20347 | VAMP8 | 8673 | 202546_at | -1.1968 | 0.0000 | |
| GSE23400 | VAMP8 | 8673 | 202546_at | -0.6288 | 0.0000 | |
| GSE26886 | VAMP8 | 8673 | 202546_at | -1.9389 | 0.0000 | |
| GSE29001 | VAMP8 | 8673 | 202546_at | -1.1936 | 0.0162 | |
| GSE38129 | VAMP8 | 8673 | 202546_at | -0.4055 | 0.1996 | |
| GSE45670 | VAMP8 | 8673 | 202546_at | -0.0371 | 0.8361 | |
| GSE53622 | VAMP8 | 8673 | 5734 | -0.6926 | 0.0000 | |
| GSE53624 | VAMP8 | 8673 | 5734 | -0.7786 | 0.0000 | |
| GSE63941 | VAMP8 | 8673 | 202546_at | 3.8362 | 0.0013 | |
| GSE77861 | VAMP8 | 8673 | 202546_at | -0.7152 | 0.0149 | |
| GSE97050 | VAMP8 | 8673 | A_23_P28434 | 0.4105 | 0.4820 | |
| SRP007169 | VAMP8 | 8673 | RNAseq | -2.0054 | 0.0000 | |
| SRP008496 | VAMP8 | 8673 | RNAseq | -1.7282 | 0.0000 | |
| SRP064894 | VAMP8 | 8673 | RNAseq | -0.5777 | 0.0656 | |
| SRP133303 | VAMP8 | 8673 | RNAseq | -0.6419 | 0.0000 | |
| SRP159526 | VAMP8 | 8673 | RNAseq | -0.9909 | 0.0019 | |
| SRP193095 | VAMP8 | 8673 | RNAseq | -1.2784 | 0.0000 | |
| SRP219564 | VAMP8 | 8673 | RNAseq | -0.3328 | 0.5955 | |
| TCGA | VAMP8 | 8673 | RNAseq | 0.0742 | 0.2982 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by VAMP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VAMP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VAMP8 | 8673 | 9 | 2 | 19 | |
| GSE20123 | VAMP8 | 8673 | 9 | 2 | 19 | |
| GSE43470 | VAMP8 | 8673 | 6 | 2 | 35 | |
| GSE46452 | VAMP8 | 8673 | 2 | 3 | 54 | |
| GSE47630 | VAMP8 | 8673 | 7 | 0 | 33 | |
| GSE54993 | VAMP8 | 8673 | 0 | 6 | 64 | |
| GSE54994 | VAMP8 | 8673 | 10 | 0 | 43 | |
| GSE60625 | VAMP8 | 8673 | 0 | 3 | 8 | |
| GSE74703 | VAMP8 | 8673 | 5 | 1 | 30 | |
| GSE74704 | VAMP8 | 8673 | 7 | 0 | 13 | |
| TCGA | VAMP8 | 8673 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 22; Total Number of normals: 376.
Somatic mutations of VAMP8:
Generating mutation plots.
Highly correlated genes for VAMP8:
Showing top 20/1256 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VAMP8 | RBM47 | 0.782263 | 12 | 0 | 12 |
| VAMP8 | ARAP2 | 0.778905 | 3 | 0 | 3 |
| VAMP8 | MAL2 | 0.774843 | 8 | 0 | 7 |
| VAMP8 | RAB27B | 0.763294 | 10 | 0 | 9 |
| VAMP8 | GRN | 0.760135 | 8 | 0 | 8 |
| VAMP8 | LIPH | 0.758057 | 7 | 0 | 6 |
| VAMP8 | TECR | 0.756338 | 12 | 0 | 11 |
| VAMP8 | TMEM154 | 0.754432 | 7 | 0 | 7 |
| VAMP8 | EPHA1 | 0.747473 | 12 | 0 | 11 |
| VAMP8 | VPS25 | 0.74379 | 5 | 0 | 4 |
| VAMP8 | FAM160A1 | 0.741229 | 7 | 0 | 7 |
| VAMP8 | ARHGAP27 | 0.739128 | 8 | 0 | 7 |
| VAMP8 | ARPC3 | 0.73867 | 12 | 0 | 11 |
| VAMP8 | NAGK | 0.737241 | 11 | 0 | 10 |
| VAMP8 | CD24 | 0.737212 | 12 | 0 | 12 |
| VAMP8 | DENND2D | 0.736229 | 11 | 0 | 9 |
| VAMP8 | CDS1 | 0.731454 | 12 | 0 | 11 |
| VAMP8 | RAB25 | 0.728847 | 13 | 0 | 11 |
| VAMP8 | MPZL3 | 0.728554 | 7 | 0 | 6 |
| VAMP8 | LNX1 | 0.728314 | 5 | 0 | 5 |
For details and further investigation, click here
