Full name: actin related protein 2/3 complex subunit 5	Alias Symbol: p16-Arc|ARC16|dJ127C7.3
Type: protein-coding gene	Cytoband: 1q25.3
Entrez ID: 10092	HGNC ID: HGNC:708	Ensembl Gene: ENSG00000162704	OMIM ID: 604227
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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ARPC5 involved pathways:

KEGG pathway	Description	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04810	Regulation of actin cytoskeleton	View
hsa05100	Bacterial invasion of epithelial cells	View
hsa05130	Pathogenic Escherichia coli infection	View
hsa05131	Shigellosis	View
hsa05132	Salmonella infection	View

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Expression of ARPC5:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ARPC5	10092	211963_s_at	0.4995	0.1683	Show
GSE20347	ARPC5	10092	211963_s_at	-0.0277	0.8701	Show
GSE23400	ARPC5	10092	211963_s_at	0.1704	0.0036	Show
GSE26886	ARPC5	10092	211963_s_at	-0.7170	0.0000	Show
GSE29001	ARPC5	10092	211963_s_at	0.0359	0.9357	Show
GSE38129	ARPC5	10092	211963_s_at	0.2290	0.0704	Show
GSE45670	ARPC5	10092	211963_s_at	0.0887	0.3935	Show
GSE53622	ARPC5	10092	23456	0.1063	0.0686	Show
GSE53624	ARPC5	10092	23456	-0.0149	0.7794	Show
GSE63941	ARPC5	10092	211963_s_at	-0.3228	0.3853	Show
GSE77861	ARPC5	10092	211963_s_at	0.0311	0.9262	Show
GSE97050	ARPC5	10092	A_23_P126803	0.4168	0.2830	Show
SRP007169	ARPC5	10092	RNAseq	-0.4246	0.1328	Show
SRP008496	ARPC5	10092	RNAseq	-0.2305	0.2454	Show
SRP064894	ARPC5	10092	RNAseq	0.2907	0.0349	Show
SRP133303	ARPC5	10092	RNAseq	0.2492	0.0493	Show
SRP159526	ARPC5	10092	RNAseq	0.0898	0.7695	Show
SRP193095	ARPC5	10092	RNAseq	-0.2005	0.0353	Show
SRP219564	ARPC5	10092	RNAseq	0.0982	0.7552	Show
TCGA	ARPC5	10092	RNAseq	0.1737	0.0001	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by ARPC5 expression:

 

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Copy number change of ARPC5:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ARPC5	10092	12	0	18	Show
GSE20123	ARPC5	10092	12	0	18	Show
GSE43470	ARPC5	10092	7	1	35	Show
GSE46452	ARPC5	10092	3	1	55	Show
GSE47630	ARPC5	10092	14	0	26	Show
GSE54993	ARPC5	10092	0	6	64	Show
GSE54994	ARPC5	10092	15	0	38	Show
GSE60625	ARPC5	10092	0	0	11	Show
GSE74703	ARPC5	10092	7	1	28	Show
GSE74704	ARPC5	10092	5	0	15	Show
TCGA	ARPC5	10092	40	3	53	Show

Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.  Download Data

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Somatic mutations of ARPC5:

 

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Highly correlated genes for ARPC5:

 

Showing top 20/480 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ARPC5	TCF19	0.764084	3	0	3
ARPC5	PDE8A	0.752087	3	0	3
ARPC5	CCDC117	0.746739	3	0	3
ARPC5	FASTKD2	0.74267	3	0	3
ARPC5	RCOR1	0.738951	3	0	3
ARPC5	PLIN2	0.73399	3	0	3
ARPC5	ACBD5	0.721839	3	0	3
ARPC5	ATIC	0.717396	3	0	3
ARPC5	TRAPPC6B	0.715663	3	0	3
ARPC5	MSL3	0.711091	4	0	3
ARPC5	WWP1	0.710035	3	0	3
ARPC5	ISCA2	0.708201	3	0	3
ARPC5	C2CD2	0.707285	4	0	4
ARPC5	CRK	0.7069	4	0	4
ARPC5	TMEM167A	0.706523	4	0	3
ARPC5	PLEKHB2	0.706356	5	0	5
ARPC5	NFKB1	0.704389	5	0	4
ARPC5	TDP1	0.704353	4	0	3
ARPC5	FKTN	0.703816	3	0	3
ARPC5	UBA3	0.702881	4	0	4

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