| Full name: ankyrin repeat and SOCS box containing 8 | Alias Symbol: MGC5540|FLJ21255 | ||
| Type: protein-coding gene | Cytoband: 12q13.11 | ||
| Entrez ID: 140461 | HGNC ID: HGNC:17183 | Ensembl Gene: ENSG00000177981 | OMIM ID: 615053 |
| Drug and gene relationship at DGIdb | |||
Expression of ASB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASB8 | 140461 | 226861_at | -0.5693 | 0.2968 | |
| GSE20347 | ASB8 | 140461 | 218841_at | -0.2873 | 0.0061 | |
| GSE23400 | ASB8 | 140461 | 218841_at | -0.2278 | 0.0000 | |
| GSE26886 | ASB8 | 140461 | 218841_at | -1.0585 | 0.0002 | |
| GSE29001 | ASB8 | 140461 | 218841_at | -0.7058 | 0.0162 | |
| GSE38129 | ASB8 | 140461 | 218841_at | -0.4406 | 0.0485 | |
| GSE45670 | ASB8 | 140461 | 226861_at | -0.3446 | 0.0198 | |
| GSE53622 | ASB8 | 140461 | 22516 | -0.6428 | 0.0000 | |
| GSE53624 | ASB8 | 140461 | 22516 | -0.5702 | 0.0000 | |
| GSE63941 | ASB8 | 140461 | 226861_at | -1.2253 | 0.0053 | |
| GSE77861 | ASB8 | 140461 | 226861_at | -0.3051 | 0.3280 | |
| GSE97050 | ASB8 | 140461 | A_24_P643587 | -0.3889 | 0.1760 | |
| SRP007169 | ASB8 | 140461 | RNAseq | -0.9867 | 0.0242 | |
| SRP008496 | ASB8 | 140461 | RNAseq | -0.9939 | 0.0001 | |
| SRP064894 | ASB8 | 140461 | RNAseq | -0.6381 | 0.0000 | |
| SRP133303 | ASB8 | 140461 | RNAseq | -0.4027 | 0.0026 | |
| SRP159526 | ASB8 | 140461 | RNAseq | -0.4870 | 0.0218 | |
| SRP193095 | ASB8 | 140461 | RNAseq | -0.6655 | 0.0000 | |
| SRP219564 | ASB8 | 140461 | RNAseq | -0.6528 | 0.0122 | |
| TCGA | ASB8 | 140461 | RNAseq | -0.2056 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ASB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASB8 | 140461 | 6 | 1 | 23 | |
| GSE20123 | ASB8 | 140461 | 6 | 1 | 23 | |
| GSE43470 | ASB8 | 140461 | 3 | 1 | 39 | |
| GSE46452 | ASB8 | 140461 | 8 | 1 | 50 | |
| GSE47630 | ASB8 | 140461 | 11 | 2 | 27 | |
| GSE54993 | ASB8 | 140461 | 0 | 5 | 65 | |
| GSE54994 | ASB8 | 140461 | 6 | 1 | 46 | |
| GSE60625 | ASB8 | 140461 | 0 | 0 | 11 | |
| GSE74703 | ASB8 | 140461 | 3 | 1 | 32 | |
| GSE74704 | ASB8 | 140461 | 4 | 1 | 15 | |
| TCGA | ASB8 | 140461 | 16 | 12 | 68 |
Total number of gains: 63; Total number of losses: 26; Total Number of normals: 399.
Somatic mutations of ASB8:
Generating mutation plots.
Highly correlated genes for ASB8:
Showing top 20/1303 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASB8 | ING4 | 0.84795 | 3 | 0 | 3 |
| ASB8 | RHBDD1 | 0.816177 | 3 | 0 | 3 |
| ASB8 | MNS1 | 0.772201 | 3 | 0 | 3 |
| ASB8 | TRIM68 | 0.747989 | 3 | 0 | 3 |
| ASB8 | ANAPC16 | 0.737879 | 3 | 0 | 3 |
| ASB8 | MTMR10 | 0.736161 | 5 | 0 | 5 |
| ASB8 | MSL2 | 0.734145 | 3 | 0 | 3 |
| ASB8 | ABHD14B | 0.731578 | 5 | 0 | 5 |
| ASB8 | RHBDF1 | 0.727368 | 4 | 0 | 4 |
| ASB8 | AFF3 | 0.720852 | 3 | 0 | 3 |
| ASB8 | C6orf89 | 0.720489 | 3 | 0 | 3 |
| ASB8 | CISD1 | 0.717841 | 4 | 0 | 3 |
| ASB8 | ZNF578 | 0.710433 | 3 | 0 | 3 |
| ASB8 | PPM1L | 0.710366 | 5 | 0 | 4 |
| ASB8 | ZNF597 | 0.708825 | 3 | 0 | 3 |
| ASB8 | BAG1 | 0.706075 | 6 | 0 | 6 |
| ASB8 | GOLGA3 | 0.703436 | 4 | 0 | 4 |
| ASB8 | GPR108 | 0.703032 | 3 | 0 | 3 |
| ASB8 | CCDC159 | 0.702026 | 5 | 0 | 5 |
| ASB8 | SYNC | 0.696681 | 4 | 0 | 4 |
For details and further investigation, click here
