| Full name: ATPase H+/K+ transporting non-gastric alpha2 subunit | Alias Symbol: HK|H-K-ATPase | ||
| Type: protein-coding gene | Cytoband: 13q12.12 | ||
| Entrez ID: 479 | HGNC ID: HGNC:13816 | Ensembl Gene: ENSG00000075673 | OMIM ID: 182360 |
| Drug and gene relationship at DGIdb | |||
Expression of ATP12A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP12A | 479 | 207367_at | -0.0820 | 0.8800 | |
| GSE20347 | ATP12A | 479 | 207367_at | -0.1103 | 0.6785 | |
| GSE23400 | ATP12A | 479 | 207367_at | -0.1394 | 0.1720 | |
| GSE26886 | ATP12A | 479 | 207367_at | -1.8048 | 0.0000 | |
| GSE29001 | ATP12A | 479 | 207367_at | -0.1896 | 0.5881 | |
| GSE38129 | ATP12A | 479 | 207367_at | -0.0542 | 0.8262 | |
| GSE45670 | ATP12A | 479 | 207367_at | 0.1902 | 0.6131 | |
| GSE53622 | ATP12A | 479 | 32172 | 0.0569 | 0.7223 | |
| GSE53624 | ATP12A | 479 | 160948 | -1.3508 | 0.0000 | |
| GSE63941 | ATP12A | 479 | 207367_at | 0.6155 | 0.2258 | |
| GSE77861 | ATP12A | 479 | 207367_at | -0.7397 | 0.0690 | |
| GSE97050 | ATP12A | 479 | A_23_P87982 | -0.0853 | 0.8133 | |
| SRP007169 | ATP12A | 479 | RNAseq | 0.3154 | 0.7501 | |
| SRP064894 | ATP12A | 479 | RNAseq | -0.1772 | 0.8356 | |
| SRP133303 | ATP12A | 479 | RNAseq | -0.7744 | 0.3655 | |
| SRP159526 | ATP12A | 479 | RNAseq | -0.5944 | 0.7195 | |
| TCGA | ATP12A | 479 | RNAseq | 1.3835 | 0.0390 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ATP12A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP12A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP12A | 479 | 1 | 12 | 17 | |
| GSE20123 | ATP12A | 479 | 1 | 11 | 18 | |
| GSE43470 | ATP12A | 479 | 2 | 13 | 28 | |
| GSE46452 | ATP12A | 479 | 0 | 33 | 26 | |
| GSE47630 | ATP12A | 479 | 3 | 26 | 11 | |
| GSE54993 | ATP12A | 479 | 11 | 2 | 57 | |
| GSE54994 | ATP12A | 479 | 1 | 13 | 39 | |
| GSE60625 | ATP12A | 479 | 0 | 3 | 8 | |
| GSE74703 | ATP12A | 479 | 2 | 10 | 24 | |
| GSE74704 | ATP12A | 479 | 0 | 9 | 11 | |
| TCGA | ATP12A | 479 | 5 | 46 | 45 |
Total number of gains: 26; Total number of losses: 178; Total Number of normals: 284.
Somatic mutations of ATP12A:
Generating mutation plots.
Highly correlated genes for ATP12A:
Showing top 20/287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP12A | GJA3 | 0.729774 | 3 | 0 | 3 |
| ATP12A | GJB1 | 0.729314 | 3 | 0 | 3 |
| ATP12A | C6orf132 | 0.721631 | 4 | 0 | 4 |
| ATP12A | GPR45 | 0.698013 | 3 | 0 | 3 |
| ATP12A | VSIG10L | 0.697196 | 4 | 0 | 3 |
| ATP12A | NHP2 | 0.695623 | 3 | 0 | 3 |
| ATP12A | HS3ST6 | 0.687735 | 4 | 0 | 3 |
| ATP12A | DEGS2 | 0.687448 | 5 | 0 | 4 |
| ATP12A | KCNA7 | 0.68236 | 3 | 0 | 3 |
| ATP12A | KRT24 | 0.678365 | 4 | 0 | 3 |
| ATP12A | TMEM79 | 0.673578 | 4 | 0 | 4 |
| ATP12A | GRHL3 | 0.666961 | 5 | 0 | 4 |
| ATP12A | CNFN | 0.662345 | 5 | 0 | 4 |
| ATP12A | PRRT3 | 0.660092 | 3 | 0 | 3 |
| ATP12A | GJB6 | 0.657957 | 4 | 0 | 4 |
| ATP12A | LIPH | 0.657618 | 4 | 0 | 4 |
| ATP12A | PRSS27 | 0.65753 | 5 | 0 | 4 |
| ATP12A | SEC13 | 0.654207 | 4 | 0 | 4 |
| ATP12A | SEMA5A | 0.65127 | 3 | 0 | 3 |
| ATP12A | RHBDL2 | 0.649244 | 5 | 0 | 4 |
For details and further investigation, click here
