CDC27

 

Full name: cell division cycle 27 Alias Symbol: APC3|ANAPC3|NUC2
Type: protein-coding gene Cytoband: 17q21.32
Entrez ID: 996 HGNC ID: HGNC:1728 Ensembl Gene: ENSG00000004897 OMIM ID: 116946
Drug and gene relationship at DGIdb

 

CDC27 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
hsa05166HTLV-I infection

 

Expression of CDC27:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC27 996 217880_at 0.2371 0.4716
GSE20347 CDC27 996 217880_at 0.1592 0.2078
GSE23400 CDC27 996 217878_s_at 0.1222 0.1448
GSE26886 CDC27 996 217880_at 0.1712 0.4150
GSE29001 CDC27 996 217879_at 0.4714 0.0500
GSE38129 CDC27 996 217880_at 0.2967 0.0051
GSE45670 CDC27 996 217878_s_at 0.0337 0.9035
GSE53622 CDC27 996 107997 0.5212 0.0000
GSE53624 CDC27 996 107997 0.5620 0.0000
GSE63941 CDC27 996 217880_at -0.9624 0.0290
GSE77861 CDC27 996 217879_at 0.6419 0.0283
GSE97050 CDC27 996 A_23_P66777 0.4511 0.1858
SRP007169 CDC27 996 RNAseq 0.6333 0.0449
SRP008496 CDC27 996 RNAseq 0.6231 0.0002
SRP064894 CDC27 996 RNAseq 0.5724 0.0008
SRP133303 CDC27 996 RNAseq 0.5478 0.0001
SRP159526 CDC27 996 RNAseq 0.3294 0.1345
SRP193095 CDC27 996 RNAseq 0.3033 0.0019
SRP219564 CDC27 996 RNAseq 0.3993 0.1328
TCGA CDC27 996 RNAseq 0.1195 0.0101

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CDC27 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC27:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC27 996 5 2 23
GSE20123 CDC27 996 5 2 23
GSE43470 CDC27 996 1 2 40
GSE46452 CDC27 996 32 0 27
GSE47630 CDC27 996 9 0 31
GSE54993 CDC27 996 2 4 64
GSE54994 CDC27 996 11 5 37
GSE60625 CDC27 996 4 0 7
GSE74703 CDC27 996 1 1 34
GSE74704 CDC27 996 4 1 15
TCGA CDC27 996 26 6 64

Total number of gains: 100; Total number of losses: 23; Total Number of normals: 365.  

 

Somatic mutations of CDC27:

 

Generating mutation plots.

 

Highly correlated genes for CDC27:

 

Showing top 20/1026 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC27UBA60.807975303
CDC27PLEKHB20.79494303
CDC27NF10.762184303
CDC27ATP1A10.748185303
CDC27TES0.734677303
CDC27RAB340.732944303
CDC27CDC370.730546303
CDC27PLEKHO20.727265303
CDC27KHDC10.721768303
CDC27PYCR20.721708303
CDC27HOOK30.721686303
CDC27WDR360.716371404
CDC27PPIP5K20.713233303
CDC27SCNM10.711801303
CDC27FADS10.708225303
CDC27SPOPL0.707651303
CDC27PPIG0.707199403
CDC27SASS60.706818403
CDC27KCNJ150.705829303
CDC27RFTN10.70247403

For details and further investigation, click here