| Full name: RecQ mediated genome instability 2 | Alias Symbol: MGC24665|BLAP18 | ||
| Type: protein-coding gene | Cytoband: 16p13.13 | ||
| Entrez ID: 116028 | HGNC ID: HGNC:28349 | Ensembl Gene: ENSG00000175643 | OMIM ID: 612426 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RMI2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of RMI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RMI2 | 116028 | 226456_at | 0.1860 | 0.8121 | |
| GSE26886 | RMI2 | 116028 | 226456_at | 0.1071 | 0.6047 | |
| GSE45670 | RMI2 | 116028 | 226456_at | 0.8414 | 0.0045 | |
| GSE53622 | RMI2 | 116028 | 77799 | 1.3484 | 0.0000 | |
| GSE53624 | RMI2 | 116028 | 77799 | 1.3705 | 0.0000 | |
| GSE63941 | RMI2 | 116028 | 226456_at | 3.2629 | 0.0001 | |
| GSE77861 | RMI2 | 116028 | 226456_at | 0.5373 | 0.0817 | |
| GSE97050 | RMI2 | 116028 | A_23_P353717 | 0.6059 | 0.1818 | |
| SRP007169 | RMI2 | 116028 | RNAseq | 1.3138 | 0.0069 | |
| SRP008496 | RMI2 | 116028 | RNAseq | 0.9677 | 0.0099 | |
| SRP064894 | RMI2 | 116028 | RNAseq | 1.1666 | 0.0001 | |
| SRP133303 | RMI2 | 116028 | RNAseq | 1.1251 | 0.0008 | |
| SRP159526 | RMI2 | 116028 | RNAseq | 1.3283 | 0.0006 | |
| SRP193095 | RMI2 | 116028 | RNAseq | 0.6338 | 0.0003 | |
| SRP219564 | RMI2 | 116028 | RNAseq | 1.5574 | 0.0167 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by RMI2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of RMI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RMI2 | 116028 | 5 | 4 | 21 | |
| GSE20123 | RMI2 | 116028 | 5 | 3 | 22 | |
| GSE43470 | RMI2 | 116028 | 3 | 3 | 37 | |
| GSE46452 | RMI2 | 116028 | 38 | 1 | 20 | |
| GSE47630 | RMI2 | 116028 | 14 | 6 | 20 | |
| GSE54993 | RMI2 | 116028 | 3 | 5 | 62 | |
| GSE54994 | RMI2 | 116028 | 5 | 9 | 39 | |
| GSE60625 | RMI2 | 116028 | 4 | 0 | 7 | |
| GSE74703 | RMI2 | 116028 | 3 | 2 | 31 | |
| GSE74704 | RMI2 | 116028 | 2 | 1 | 17 | |
| TCGA | RMI2 | 116028 | 20 | 12 | 64 |
Total number of gains: 102; Total number of losses: 46; Total Number of normals: 340.
Somatic mutations of RMI2:
Generating mutation plots.
Highly correlated genes for RMI2:
Showing top 20/1030 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RMI2 | UBE2T | 0.752861 | 6 | 0 | 6 |
| RMI2 | BLM | 0.745509 | 6 | 0 | 5 |
| RMI2 | MCM2 | 0.743701 | 6 | 0 | 6 |
| RMI2 | EXO1 | 0.743037 | 5 | 0 | 5 |
| RMI2 | CDT1 | 0.741495 | 7 | 0 | 6 |
| RMI2 | RPA3 | 0.729227 | 7 | 0 | 7 |
| RMI2 | CDCA3 | 0.725043 | 7 | 0 | 6 |
| RMI2 | RFC2 | 0.723889 | 6 | 0 | 6 |
| RMI2 | TTK | 0.722488 | 7 | 0 | 7 |
| RMI2 | GMNN | 0.721448 | 6 | 0 | 5 |
| RMI2 | CCNA1 | 0.720083 | 3 | 0 | 3 |
| RMI2 | CENPN | 0.71926 | 7 | 0 | 6 |
| RMI2 | PRIM1 | 0.719001 | 7 | 0 | 7 |
| RMI2 | CENPA | 0.714066 | 7 | 0 | 6 |
| RMI2 | ASF1B | 0.712999 | 6 | 0 | 6 |
| RMI2 | CEP55 | 0.709705 | 7 | 0 | 7 |
| RMI2 | MCM5 | 0.709354 | 5 | 0 | 5 |
| RMI2 | MND1 | 0.70756 | 7 | 0 | 6 |
| RMI2 | UBE2C | 0.706693 | 7 | 0 | 7 |
| RMI2 | DKC1 | 0.706629 | 3 | 0 | 3 |
For details and further investigation, click here
