ATP2B1

 

Full name: ATPase plasma membrane Ca2+ transporting 1 Alias Symbol: PMCA1
Type: protein-coding gene Cytoband: 12q21.33
Entrez ID: 490 HGNC ID: HGNC:814 Ensembl Gene: ENSG00000070961 OMIM ID: 108731
Drug and gene relationship at DGIdb
Screen Evidence:

 

ATP2B1 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04961Endocrine and other factor-regulated calcium reabsorption

 

Expression of ATP2B1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP2B1 490 215716_s_at 0.8205 0.0548
GSE20347 ATP2B1 490 209281_s_at 0.7663 0.0030
GSE23400 ATP2B1 490 209281_s_at 0.7841 0.0000
GSE26886 ATP2B1 490 215716_s_at 2.2555 0.0000
GSE29001 ATP2B1 490 215716_s_at 0.6511 0.1964
GSE38129 ATP2B1 490 209281_s_at 0.9223 0.0001
GSE45670 ATP2B1 490 215716_s_at 0.5350 0.1386
GSE53622 ATP2B1 490 126282 0.8494 0.0000
GSE53624 ATP2B1 490 126282 0.8378 0.0000
GSE63941 ATP2B1 490 215716_s_at -1.2124 0.1650
GSE77861 ATP2B1 490 215716_s_at 2.0307 0.0044
GSE97050 ATP2B1 490 A_33_P3267186 0.4635 0.1864
SRP007169 ATP2B1 490 RNAseq 2.5514 0.0000
SRP008496 ATP2B1 490 RNAseq 2.7839 0.0000
SRP064894 ATP2B1 490 RNAseq 0.7705 0.0013
SRP133303 ATP2B1 490 RNAseq 0.7003 0.0011
SRP159526 ATP2B1 490 RNAseq 1.6428 0.0011
SRP193095 ATP2B1 490 RNAseq 0.5526 0.0215
SRP219564 ATP2B1 490 RNAseq 1.2422 0.0016
TCGA ATP2B1 490 RNAseq 0.0074 0.9172

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by ATP2B1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP2B1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP2B1 490 3 2 25
GSE20123 ATP2B1 490 3 2 25
GSE43470 ATP2B1 490 3 0 40
GSE46452 ATP2B1 490 9 1 49
GSE47630 ATP2B1 490 10 1 29
GSE54993 ATP2B1 490 0 6 64
GSE54994 ATP2B1 490 6 1 46
GSE60625 ATP2B1 490 0 0 11
GSE74703 ATP2B1 490 3 0 33
GSE74704 ATP2B1 490 1 2 17
TCGA ATP2B1 490 19 10 67

Total number of gains: 57; Total number of losses: 25; Total Number of normals: 406.  

 

Somatic mutations of ATP2B1:

 

Generating mutation plots.

 

Highly correlated genes for ATP2B1:

 

Showing top 20/1094 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP2B1BLOC1S60.732027303
ATP2B1MAPK60.710579303
ATP2B1ZCCHC70.706287303
ATP2B1COPRS0.700554303
ATP2B1WDR810.7001404
ATP2B1MIEN10.699472303
ATP2B1COA60.696028606
ATP2B1LRP80.693154707
ATP2B1TREM20.692716303
ATP2B1C1orf1310.689169706
ATP2B1SMARCAD10.685426303
ATP2B1LRRC580.677994505
ATP2B1CTU20.676872504
ATP2B1PHLDB20.676445605
ATP2B1GNG100.674336303
ATP2B1MRPL140.674032403
ATP2B1COL13A10.672871303
ATP2B1CCDC860.67202807
ATP2B1CYP27C10.671421303
ATP2B1FAM89A0.67137303

For details and further investigation, click here