| Full name: ataxin 3 | Alias Symbol: ATX3|JOS | ||
| Type: protein-coding gene | Cytoband: 14q32.12 | ||
| Entrez ID: 4287 | HGNC ID: HGNC:7106 | Ensembl Gene: ENSG00000066427 | OMIM ID: 607047 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATXN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATXN3 | 4287 | 205415_s_at | 0.0813 | 0.9474 | |
| GSE20347 | ATXN3 | 4287 | 205415_s_at | -0.0992 | 0.6746 | |
| GSE23400 | ATXN3 | 4287 | 205416_s_at | 0.1372 | 0.0108 | |
| GSE26886 | ATXN3 | 4287 | 235240_at | -0.5364 | 0.0047 | |
| GSE29001 | ATXN3 | 4287 | 205416_s_at | 0.0072 | 0.9785 | |
| GSE38129 | ATXN3 | 4287 | 205415_s_at | 0.0436 | 0.8056 | |
| GSE45670 | ATXN3 | 4287 | 205415_s_at | 0.4701 | 0.0029 | |
| GSE53622 | ATXN3 | 4287 | 70189 | 0.0530 | 0.5435 | |
| GSE53624 | ATXN3 | 4287 | 70189 | 0.2456 | 0.0000 | |
| GSE63941 | ATXN3 | 4287 | 205415_s_at | 0.4714 | 0.4313 | |
| GSE77861 | ATXN3 | 4287 | 205415_s_at | -0.2312 | 0.6244 | |
| GSE97050 | ATXN3 | 4287 | A_33_P3275310 | 0.1669 | 0.3835 | |
| SRP007169 | ATXN3 | 4287 | RNAseq | -0.2463 | 0.4825 | |
| SRP008496 | ATXN3 | 4287 | RNAseq | -0.1665 | 0.4601 | |
| SRP064894 | ATXN3 | 4287 | RNAseq | 0.1379 | 0.2446 | |
| SRP133303 | ATXN3 | 4287 | RNAseq | 0.0089 | 0.9499 | |
| SRP159526 | ATXN3 | 4287 | RNAseq | -0.4806 | 0.0445 | |
| SRP193095 | ATXN3 | 4287 | RNAseq | -0.2540 | 0.0088 | |
| SRP219564 | ATXN3 | 4287 | RNAseq | -0.1575 | 0.6566 | |
| TCGA | ATXN3 | 4287 | RNAseq | -0.0100 | 0.8548 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATXN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATXN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATXN3 | 4287 | 9 | 5 | 16 | |
| GSE20123 | ATXN3 | 4287 | 9 | 4 | 17 | |
| GSE43470 | ATXN3 | 4287 | 7 | 3 | 33 | |
| GSE46452 | ATXN3 | 4287 | 16 | 3 | 40 | |
| GSE47630 | ATXN3 | 4287 | 11 | 8 | 21 | |
| GSE54993 | ATXN3 | 4287 | 3 | 8 | 59 | |
| GSE54994 | ATXN3 | 4287 | 20 | 4 | 29 | |
| GSE60625 | ATXN3 | 4287 | 0 | 2 | 9 | |
| GSE74703 | ATXN3 | 4287 | 6 | 3 | 27 | |
| GSE74704 | ATXN3 | 4287 | 4 | 3 | 13 | |
| TCGA | ATXN3 | 4287 | 30 | 21 | 45 |
Total number of gains: 115; Total number of losses: 64; Total Number of normals: 309.
Somatic mutations of ATXN3:
Generating mutation plots.
Highly correlated genes for ATXN3:
Showing top 20/65 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATXN3 | AASDH | 0.709645 | 3 | 0 | 3 |
| ATXN3 | COX16 | 0.674208 | 3 | 0 | 3 |
| ATXN3 | CAB39 | 0.664143 | 3 | 0 | 3 |
| ATXN3 | AK4 | 0.634698 | 3 | 0 | 3 |
| ATXN3 | CCNK | 0.620462 | 5 | 0 | 5 |
| ATXN3 | OSBPL2 | 0.612485 | 3 | 0 | 3 |
| ATXN3 | TRIM23 | 0.610547 | 5 | 0 | 4 |
| ATXN3 | TC2N | 0.607489 | 4 | 0 | 3 |
| ATXN3 | C1orf53 | 0.602751 | 3 | 0 | 3 |
| ATXN3 | ZMAT2 | 0.59792 | 4 | 0 | 3 |
| ATXN3 | EIF5 | 0.584938 | 6 | 0 | 4 |
| ATXN3 | TRIP11 | 0.581175 | 8 | 0 | 6 |
| ATXN3 | RDH11 | 0.580359 | 9 | 0 | 8 |
| ATXN3 | PRPF39 | 0.578592 | 7 | 0 | 4 |
| ATXN3 | TPP2 | 0.572506 | 4 | 0 | 3 |
| ATXN3 | SUCO | 0.571359 | 3 | 0 | 3 |
| ATXN3 | MFSD6 | 0.569964 | 3 | 0 | 3 |
| ATXN3 | RBM8A | 0.567114 | 5 | 0 | 3 |
| ATXN3 | BTBD7 | 0.564305 | 10 | 0 | 7 |
| ATXN3 | HOOK1 | 0.561924 | 4 | 0 | 3 |
For details and further investigation, click here
