| Full name: transmembrane channel like 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 147798 | HGNC ID: HGNC:22998 | Ensembl Gene: ENSG00000167608 | OMIM ID: 617181 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMC4 | 147798 | 226403_at | -0.8528 | 0.1802 | |
| GSE26886 | TMC4 | 147798 | 226403_at | -0.2736 | 0.6680 | |
| GSE45670 | TMC4 | 147798 | 226403_at | -0.9580 | 0.0266 | |
| GSE53622 | TMC4 | 147798 | 20788 | -0.9986 | 0.0000 | |
| GSE53624 | TMC4 | 147798 | 20788 | -1.2101 | 0.0000 | |
| GSE63941 | TMC4 | 147798 | 226403_at | 3.0806 | 0.0022 | |
| GSE77861 | TMC4 | 147798 | 226403_at | -0.7085 | 0.0741 | |
| GSE97050 | TMC4 | 147798 | A_23_P330461 | 0.1174 | 0.8840 | |
| SRP007169 | TMC4 | 147798 | RNAseq | -2.3252 | 0.0003 | |
| SRP008496 | TMC4 | 147798 | RNAseq | -1.9372 | 0.0003 | |
| SRP064894 | TMC4 | 147798 | RNAseq | -0.3968 | 0.3656 | |
| SRP133303 | TMC4 | 147798 | RNAseq | -0.7441 | 0.0926 | |
| SRP159526 | TMC4 | 147798 | RNAseq | -0.3999 | 0.5005 | |
| SRP193095 | TMC4 | 147798 | RNAseq | -0.8354 | 0.0044 | |
| SRP219564 | TMC4 | 147798 | RNAseq | 0.0691 | 0.9148 | |
| TCGA | TMC4 | 147798 | RNAseq | -0.3676 | 0.0362 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by TMC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC4 | 147798 | 3 | 4 | 23 | |
| GSE20123 | TMC4 | 147798 | 3 | 3 | 24 | |
| GSE43470 | TMC4 | 147798 | 2 | 11 | 30 | |
| GSE46452 | TMC4 | 147798 | 45 | 1 | 13 | |
| GSE47630 | TMC4 | 147798 | 8 | 6 | 26 | |
| GSE54993 | TMC4 | 147798 | 17 | 4 | 49 | |
| GSE54994 | TMC4 | 147798 | 4 | 14 | 35 | |
| GSE60625 | TMC4 | 147798 | 9 | 0 | 2 | |
| GSE74703 | TMC4 | 147798 | 2 | 7 | 27 | |
| GSE74704 | TMC4 | 147798 | 3 | 1 | 16 | |
| TCGA | TMC4 | 147798 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 66; Total Number of normals: 307.
Somatic mutations of TMC4:
Generating mutation plots.
Highly correlated genes for TMC4:
Showing top 20/475 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC4 | CAPNS2 | 0.70378 | 3 | 0 | 3 |
| TMC4 | RAD23B | 0.701275 | 3 | 0 | 3 |
| TMC4 | TJP3 | 0.690294 | 7 | 0 | 6 |
| TMC4 | BCL11A | 0.684543 | 3 | 0 | 3 |
| TMC4 | SYTL1 | 0.679984 | 8 | 0 | 7 |
| TMC4 | VAV3 | 0.678723 | 5 | 0 | 5 |
| TMC4 | TM7SF2 | 0.673149 | 6 | 0 | 6 |
| TMC4 | CD3D | 0.672921 | 3 | 0 | 3 |
| TMC4 | MPZL3 | 0.66612 | 6 | 0 | 5 |
| TMC4 | SULT2B1 | 0.665977 | 3 | 0 | 3 |
| TMC4 | SPINT1 | 0.663037 | 8 | 0 | 8 |
| TMC4 | PADI1 | 0.661316 | 4 | 0 | 3 |
| TMC4 | GCHFR | 0.658627 | 3 | 0 | 3 |
| TMC4 | COPE | 0.658279 | 3 | 0 | 3 |
| TMC4 | LINC00930 | 0.656362 | 3 | 0 | 3 |
| TMC4 | ULK3 | 0.655688 | 6 | 0 | 5 |
| TMC4 | EPN3 | 0.651054 | 7 | 0 | 5 |
| TMC4 | DENND2D | 0.65055 | 6 | 0 | 6 |
| TMC4 | TST | 0.64974 | 4 | 0 | 4 |
| TMC4 | RAB25 | 0.648816 | 7 | 0 | 6 |
For details and further investigation, click here
