| Full name: dynein light chain LC8-type 2 | Alias Symbol: MGC17810|Dlc2|DNCL1B|RSPH22 | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 140735 | HGNC ID: HGNC:24596 | Ensembl Gene: ENSG00000264364 | OMIM ID: 608942 |
| Drug and gene relationship at DGIdb | |||
Expression of DYNLL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYNLL2 | 140735 | 225494_at | -0.1270 | 0.7745 | |
| GSE26886 | DYNLL2 | 140735 | 225494_at | -0.4849 | 0.0119 | |
| GSE45670 | DYNLL2 | 140735 | 225494_at | -0.3188 | 0.0301 | |
| GSE53622 | DYNLL2 | 140735 | 72812 | -0.4023 | 0.0000 | |
| GSE53624 | DYNLL2 | 140735 | 72812 | 0.1078 | 0.1302 | |
| GSE63941 | DYNLL2 | 140735 | 225494_at | 0.1091 | 0.7343 | |
| GSE77861 | DYNLL2 | 140735 | 225494_at | 0.0075 | 0.9882 | |
| GSE97050 | DYNLL2 | 140735 | A_23_P54991 | -0.8858 | 0.0631 | |
| SRP007169 | DYNLL2 | 140735 | RNAseq | 0.0643 | 0.8395 | |
| SRP008496 | DYNLL2 | 140735 | RNAseq | 0.1024 | 0.5333 | |
| SRP064894 | DYNLL2 | 140735 | RNAseq | -0.1074 | 0.5515 | |
| SRP133303 | DYNLL2 | 140735 | RNAseq | 0.1370 | 0.5085 | |
| SRP159526 | DYNLL2 | 140735 | RNAseq | 0.4803 | 0.0431 | |
| SRP193095 | DYNLL2 | 140735 | RNAseq | 0.0499 | 0.7171 | |
| SRP219564 | DYNLL2 | 140735 | RNAseq | -0.2828 | 0.4802 | |
| TCGA | DYNLL2 | 140735 | RNAseq | -0.1140 | 0.0596 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DYNLL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYNLL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYNLL2 | 140735 | 5 | 1 | 24 | |
| GSE20123 | DYNLL2 | 140735 | 5 | 1 | 24 | |
| GSE43470 | DYNLL2 | 140735 | 3 | 0 | 40 | |
| GSE46452 | DYNLL2 | 140735 | 32 | 0 | 27 | |
| GSE47630 | DYNLL2 | 140735 | 7 | 1 | 32 | |
| GSE54993 | DYNLL2 | 140735 | 2 | 5 | 63 | |
| GSE54994 | DYNLL2 | 140735 | 8 | 6 | 39 | |
| GSE60625 | DYNLL2 | 140735 | 4 | 0 | 7 | |
| GSE74703 | DYNLL2 | 140735 | 3 | 0 | 33 | |
| GSE74704 | DYNLL2 | 140735 | 4 | 1 | 15 | |
| TCGA | DYNLL2 | 140735 | 26 | 8 | 62 |
Total number of gains: 99; Total number of losses: 23; Total Number of normals: 366.
Somatic mutations of DYNLL2:
Generating mutation plots.
Highly correlated genes for DYNLL2:
Showing top 20/118 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYNLL2 | HOXB4 | 0.739087 | 3 | 0 | 3 |
| DYNLL2 | KAT6B | 0.721567 | 3 | 0 | 3 |
| DYNLL2 | YPEL5 | 0.706877 | 4 | 0 | 4 |
| DYNLL2 | PPP6R2 | 0.700581 | 3 | 0 | 3 |
| DYNLL2 | ABHD8 | 0.693341 | 3 | 0 | 3 |
| DYNLL2 | ABR | 0.690096 | 3 | 0 | 3 |
| DYNLL2 | DCAF8 | 0.686716 | 4 | 0 | 4 |
| DYNLL2 | ROGDI | 0.685082 | 3 | 0 | 3 |
| DYNLL2 | ZDHHC3 | 0.685036 | 4 | 0 | 3 |
| DYNLL2 | C10orf82 | 0.679839 | 3 | 0 | 3 |
| DYNLL2 | HSPB6 | 0.67771 | 3 | 0 | 3 |
| DYNLL2 | RSPH9 | 0.67681 | 3 | 0 | 3 |
| DYNLL2 | CISD3 | 0.673896 | 4 | 0 | 4 |
| DYNLL2 | UBE2D2 | 0.671621 | 3 | 0 | 3 |
| DYNLL2 | ARL2BP | 0.670198 | 4 | 0 | 3 |
| DYNLL2 | TLE2 | 0.668769 | 3 | 0 | 3 |
| DYNLL2 | MAGI1 | 0.668399 | 3 | 0 | 3 |
| DYNLL2 | VPS25 | 0.664752 | 4 | 0 | 4 |
| DYNLL2 | MYL6 | 0.659473 | 3 | 0 | 3 |
| DYNLL2 | MYLIP | 0.654488 | 4 | 0 | 3 |
For details and further investigation, click here
