| Full name: anti-silencing function 1B histone chaperone | Alias Symbol: FLJ10604 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 55723 | HGNC ID: HGNC:20996 | Ensembl Gene: ENSG00000105011 | OMIM ID: 609190 |
| Drug and gene relationship at DGIdb | |||
Expression of ASF1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASF1B | 55723 | 218115_at | 0.6957 | 0.2643 | |
| GSE20347 | ASF1B | 55723 | 218115_at | 0.7392 | 0.0000 | |
| GSE23400 | ASF1B | 55723 | 218115_at | 0.5336 | 0.0000 | |
| GSE26886 | ASF1B | 55723 | 218115_at | 0.1323 | 0.5339 | |
| GSE29001 | ASF1B | 55723 | 218115_at | 0.6594 | 0.0126 | |
| GSE38129 | ASF1B | 55723 | 218115_at | 1.1008 | 0.0000 | |
| GSE45670 | ASF1B | 55723 | 218115_at | 0.6714 | 0.0008 | |
| GSE53622 | ASF1B | 55723 | 149608 | 0.9661 | 0.0000 | |
| GSE53624 | ASF1B | 55723 | 149608 | 1.2909 | 0.0000 | |
| GSE63941 | ASF1B | 55723 | 218115_at | 2.5699 | 0.0002 | |
| GSE77861 | ASF1B | 55723 | 218115_at | 0.2099 | 0.3064 | |
| GSE97050 | ASF1B | 55723 | A_23_P119254 | 0.4386 | 0.2797 | |
| SRP007169 | ASF1B | 55723 | RNAseq | 1.5958 | 0.0034 | |
| SRP008496 | ASF1B | 55723 | RNAseq | 1.1565 | 0.0034 | |
| SRP064894 | ASF1B | 55723 | RNAseq | 1.9919 | 0.0000 | |
| SRP133303 | ASF1B | 55723 | RNAseq | 1.4821 | 0.0000 | |
| SRP159526 | ASF1B | 55723 | RNAseq | 1.1651 | 0.0121 | |
| SRP193095 | ASF1B | 55723 | RNAseq | 1.0280 | 0.0000 | |
| SRP219564 | ASF1B | 55723 | RNAseq | 2.1513 | 0.0016 | |
| TCGA | ASF1B | 55723 | RNAseq | 1.0938 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by ASF1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASF1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASF1B | 55723 | 4 | 2 | 24 | |
| GSE20123 | ASF1B | 55723 | 3 | 1 | 26 | |
| GSE43470 | ASF1B | 55723 | 2 | 6 | 35 | |
| GSE46452 | ASF1B | 55723 | 47 | 1 | 11 | |
| GSE47630 | ASF1B | 55723 | 4 | 7 | 29 | |
| GSE54993 | ASF1B | 55723 | 15 | 4 | 51 | |
| GSE54994 | ASF1B | 55723 | 6 | 13 | 34 | |
| GSE60625 | ASF1B | 55723 | 9 | 0 | 2 | |
| GSE74703 | ASF1B | 55723 | 2 | 4 | 30 | |
| GSE74704 | ASF1B | 55723 | 0 | 1 | 19 | |
| TCGA | ASF1B | 55723 | 20 | 11 | 65 |
Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.
Somatic mutations of ASF1B:
Generating mutation plots.
Highly correlated genes for ASF1B:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASF1B | RNASEH2A | 0.787839 | 13 | 0 | 12 |
| ASF1B | BIRC5 | 0.769691 | 10 | 0 | 10 |
| ASF1B | CDT1 | 0.766775 | 11 | 0 | 10 |
| ASF1B | MCM7 | 0.765427 | 12 | 0 | 12 |
| ASF1B | BOP1 | 0.761538 | 3 | 0 | 3 |
| ASF1B | NUSAP1 | 0.759585 | 11 | 0 | 11 |
| ASF1B | CEP55 | 0.748523 | 11 | 0 | 10 |
| ASF1B | C19orf48 | 0.747022 | 3 | 0 | 3 |
| ASF1B | EXO1 | 0.744691 | 12 | 0 | 11 |
| ASF1B | GINS2 | 0.741883 | 12 | 0 | 11 |
| ASF1B | MCM2 | 0.741669 | 13 | 0 | 12 |
| ASF1B | TK1 | 0.741473 | 13 | 0 | 13 |
| ASF1B | MCM10 | 0.739253 | 9 | 0 | 8 |
| ASF1B | CDC45 | 0.738756 | 12 | 0 | 12 |
| ASF1B | CDCA8 | 0.738748 | 13 | 0 | 12 |
| ASF1B | TIMELESS | 0.738538 | 11 | 0 | 11 |
| ASF1B | TPX2 | 0.737066 | 12 | 0 | 10 |
| ASF1B | LRWD1 | 0.736231 | 3 | 0 | 3 |
| ASF1B | BLM | 0.735981 | 10 | 0 | 10 |
| ASF1B | KIF2C | 0.734457 | 12 | 0 | 11 |
For details and further investigation, click here
