MCM7

 

Full name: minichromosome maintenance complex component 7 Alias Symbol: CDC47|PPP1R104
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 4176 HGNC ID: HGNC:6950 Ensembl Gene: ENSG00000166508 OMIM ID: 600592
Drug and gene relationship at DGIdb

 

MCM7 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of MCM7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MCM7 4176 210983_s_at 1.0914 0.1283
GSE20347 MCM7 4176 208795_s_at 1.4343 0.0000
GSE23400 MCM7 4176 210983_s_at 1.1782 0.0000
GSE26886 MCM7 4176 208795_s_at 0.9398 0.0001
GSE29001 MCM7 4176 208795_s_at 1.1549 0.0053
GSE38129 MCM7 4176 208795_s_at 1.4824 0.0000
GSE45670 MCM7 4176 208795_s_at 1.0262 0.0002
GSE53622 MCM7 4176 82661 1.4732 0.0000
GSE53624 MCM7 4176 82661 1.6708 0.0000
GSE63941 MCM7 4176 210983_s_at 3.5213 0.0000
GSE77861 MCM7 4176 208795_s_at 0.9567 0.0018
GSE97050 MCM7 4176 A_33_P3258223 0.6939 0.2451
SRP007169 MCM7 4176 RNAseq 2.1077 0.0001
SRP008496 MCM7 4176 RNAseq 1.8913 0.0000
SRP064894 MCM7 4176 RNAseq 1.0401 0.0000
SRP133303 MCM7 4176 RNAseq 1.3550 0.0000
SRP159526 MCM7 4176 RNAseq 1.1826 0.0000
SRP193095 MCM7 4176 RNAseq 1.5153 0.0000
SRP219564 MCM7 4176 RNAseq 1.3697 0.0000
TCGA MCM7 4176 RNAseq 0.4960 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by MCM7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MCM7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MCM7 4176 13 0 17
GSE20123 MCM7 4176 13 0 17
GSE43470 MCM7 4176 6 2 35
GSE46452 MCM7 4176 11 1 47
GSE47630 MCM7 4176 7 3 30
GSE54993 MCM7 4176 1 9 60
GSE54994 MCM7 4176 16 3 34
GSE60625 MCM7 4176 0 0 11
GSE74703 MCM7 4176 6 1 29
GSE74704 MCM7 4176 9 0 11
TCGA MCM7 4176 52 6 38

Total number of gains: 134; Total number of losses: 25; Total Number of normals: 329.  

 

Somatic mutations of MCM7:

 

Generating mutation plots.

 

Highly correlated genes for MCM7:

 

Showing top 20/1660 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MCM7MCM20.83706513012
MCM7RFC40.81207513013
MCM7UBE2C0.80723712011
MCM7SSRP10.80445111011
MCM7SIX40.80076606
MCM7RNASEH2A0.79991913012
MCM7KIF2C0.7964612012
MCM7FOXM10.79558513012
MCM7CDT10.79491411011
MCM7CDC450.79323612012
MCM7MCM30.79263511011
MCM7MYBL20.79240812012
MCM7POP70.79181812012
MCM7LSM40.7900931009
MCM7RAD510.7886912012
MCM7CENPF0.78779912012
MCM7AURKB0.78718313012
MCM7TIMELESS0.78543412012
MCM7CDK40.78353812011
MCM7DNMT10.78110812011

For details and further investigation, click here