| Full name: calpain 2 | Alias Symbol: mCANP|CANPml|CANPL2 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 824 | HGNC ID: HGNC:1479 | Ensembl Gene: ENSG00000162909 | OMIM ID: 114230 |
| Drug and gene relationship at DGIdb | |||
CAPN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04510 | Focal adhesion | |
| hsa05010 | Alzheimer's disease |
Expression of CAPN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPN2 | 824 | 208683_at | -0.3263 | 0.6166 | |
| GSE20347 | CAPN2 | 824 | 208683_at | -0.5587 | 0.0003 | |
| GSE23400 | CAPN2 | 824 | 208683_at | -0.5014 | 0.0000 | |
| GSE26886 | CAPN2 | 824 | 208683_at | -0.3677 | 0.1371 | |
| GSE29001 | CAPN2 | 824 | 208683_at | -0.8326 | 0.0185 | |
| GSE38129 | CAPN2 | 824 | 208683_at | -0.4306 | 0.0102 | |
| GSE45670 | CAPN2 | 824 | 208683_at | -0.2112 | 0.0766 | |
| GSE53622 | CAPN2 | 824 | 63067 | -0.5221 | 0.0000 | |
| GSE53624 | CAPN2 | 824 | 63067 | -0.5878 | 0.0000 | |
| GSE63941 | CAPN2 | 824 | 208683_at | -1.4379 | 0.0386 | |
| GSE77861 | CAPN2 | 824 | 208683_at | -0.1572 | 0.4689 | |
| GSE97050 | CAPN2 | 824 | A_23_P23924 | -0.0504 | 0.8922 | |
| SRP007169 | CAPN2 | 824 | RNAseq | -1.7272 | 0.0001 | |
| SRP008496 | CAPN2 | 824 | RNAseq | -1.4567 | 0.0000 | |
| SRP064894 | CAPN2 | 824 | RNAseq | -0.8522 | 0.0000 | |
| SRP133303 | CAPN2 | 824 | RNAseq | -0.1088 | 0.5899 | |
| SRP159526 | CAPN2 | 824 | RNAseq | -0.6943 | 0.1019 | |
| SRP193095 | CAPN2 | 824 | RNAseq | -0.3994 | 0.0005 | |
| SRP219564 | CAPN2 | 824 | RNAseq | -0.5745 | 0.2140 | |
| TCGA | CAPN2 | 824 | RNAseq | -0.1433 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CAPN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPN2 | 824 | 10 | 0 | 20 | |
| GSE20123 | CAPN2 | 824 | 10 | 0 | 20 | |
| GSE43470 | CAPN2 | 824 | 8 | 0 | 35 | |
| GSE46452 | CAPN2 | 824 | 3 | 1 | 55 | |
| GSE47630 | CAPN2 | 824 | 15 | 0 | 25 | |
| GSE54993 | CAPN2 | 824 | 0 | 6 | 64 | |
| GSE54994 | CAPN2 | 824 | 16 | 0 | 37 | |
| GSE60625 | CAPN2 | 824 | 0 | 0 | 11 | |
| GSE74703 | CAPN2 | 824 | 8 | 0 | 28 | |
| GSE74704 | CAPN2 | 824 | 4 | 0 | 16 | |
| TCGA | CAPN2 | 824 | 47 | 4 | 45 |
Total number of gains: 121; Total number of losses: 11; Total Number of normals: 356.
Somatic mutations of CAPN2:
Generating mutation plots.
Highly correlated genes for CAPN2:
Showing top 20/1098 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPN2 | SMAD3 | 0.794805 | 3 | 0 | 3 |
| CAPN2 | ERI2 | 0.793429 | 3 | 0 | 3 |
| CAPN2 | SBF2 | 0.762637 | 3 | 0 | 3 |
| CAPN2 | TTC23 | 0.760136 | 3 | 0 | 3 |
| CAPN2 | ZRANB1 | 0.752624 | 3 | 0 | 3 |
| CAPN2 | BCS1L | 0.740524 | 3 | 0 | 3 |
| CAPN2 | IMP3 | 0.735767 | 3 | 0 | 3 |
| CAPN2 | MRPL44 | 0.723662 | 3 | 0 | 3 |
| CAPN2 | PTGR1 | 0.714393 | 3 | 0 | 3 |
| CAPN2 | UBQLN1 | 0.713484 | 3 | 0 | 3 |
| CAPN2 | ZDHHC7 | 0.708787 | 3 | 0 | 3 |
| CAPN2 | UBE2A | 0.703221 | 4 | 0 | 3 |
| CAPN2 | VPS25 | 0.702014 | 4 | 0 | 3 |
| CAPN2 | TCHP | 0.701571 | 3 | 0 | 3 |
| CAPN2 | YTHDF2 | 0.696732 | 3 | 0 | 3 |
| CAPN2 | POLR2L | 0.692112 | 4 | 0 | 4 |
| CAPN2 | SERPINB2 | 0.68556 | 8 | 0 | 8 |
| CAPN2 | EIF4G2 | 0.685403 | 7 | 0 | 5 |
| CAPN2 | RHBDD1 | 0.684032 | 3 | 0 | 3 |
| CAPN2 | SCYL2 | 0.679708 | 4 | 0 | 3 |
For details and further investigation, click here
