| Full name: capping actin protein of muscle Z-line subunit alpha 3 | Alias Symbol: Gsg3|CAPPA3 | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 93661 | HGNC ID: HGNC:24205 | Ensembl Gene: ENSG00000177938 | OMIM ID: 608722 |
| Drug and gene relationship at DGIdb | |||
Expression of CAPZA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPZA3 | 93661 | 236888_at | -0.0322 | 0.9245 | |
| GSE26886 | CAPZA3 | 93661 | 236888_at | -0.0336 | 0.7936 | |
| GSE45670 | CAPZA3 | 93661 | 236888_at | 0.0700 | 0.5215 | |
| GSE53622 | CAPZA3 | 93661 | 45593 | -1.1357 | 0.0000 | |
| GSE53624 | CAPZA3 | 93661 | 45593 | -0.8472 | 0.0000 | |
| GSE63941 | CAPZA3 | 93661 | 236888_at | 0.2849 | 0.0617 | |
| GSE77861 | CAPZA3 | 93661 | 236888_at | -0.0108 | 0.9325 | |
| TCGA | CAPZA3 | 93661 | RNAseq | -3.4068 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CAPZA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPZA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPZA3 | 93661 | 7 | 2 | 21 | |
| GSE20123 | CAPZA3 | 93661 | 7 | 2 | 21 | |
| GSE43470 | CAPZA3 | 93661 | 8 | 4 | 31 | |
| GSE46452 | CAPZA3 | 93661 | 10 | 1 | 48 | |
| GSE47630 | CAPZA3 | 93661 | 14 | 2 | 24 | |
| GSE54993 | CAPZA3 | 93661 | 1 | 9 | 60 | |
| GSE54994 | CAPZA3 | 93661 | 11 | 2 | 40 | |
| GSE60625 | CAPZA3 | 93661 | 0 | 1 | 10 | |
| GSE74703 | CAPZA3 | 93661 | 8 | 3 | 25 | |
| GSE74704 | CAPZA3 | 93661 | 6 | 1 | 13 | |
| TCGA | CAPZA3 | 93661 | 41 | 6 | 49 |
Total number of gains: 113; Total number of losses: 33; Total Number of normals: 342.
Somatic mutations of CAPZA3:
Generating mutation plots.
Highly correlated genes for CAPZA3:
Showing top 20/28 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPZA3 | MAGEC3 | 0.685038 | 3 | 0 | 3 |
| CAPZA3 | KLKB1 | 0.662144 | 3 | 0 | 3 |
| CAPZA3 | NCR1 | 0.660911 | 3 | 0 | 3 |
| CAPZA3 | CRX | 0.656918 | 3 | 0 | 3 |
| CAPZA3 | CDRT15L2 | 0.645223 | 3 | 0 | 3 |
| CAPZA3 | CCDC50 | 0.634202 | 3 | 0 | 3 |
| CAPZA3 | C19orf57 | 0.608731 | 4 | 0 | 4 |
| CAPZA3 | SIK1 | 0.584047 | 3 | 0 | 3 |
| CAPZA3 | ROGDI | 0.583731 | 4 | 0 | 3 |
| CAPZA3 | MASP2 | 0.578854 | 4 | 0 | 3 |
| CAPZA3 | SFRP5 | 0.578067 | 4 | 0 | 3 |
| CAPZA3 | SPHKAP | 0.575179 | 4 | 0 | 3 |
| CAPZA3 | ARID5A | 0.570779 | 4 | 0 | 3 |
| CAPZA3 | SHBG | 0.569544 | 4 | 0 | 3 |
| CAPZA3 | SLIT1 | 0.567322 | 4 | 0 | 3 |
| CAPZA3 | TTR | 0.556888 | 4 | 0 | 3 |
| CAPZA3 | CMTM1 | 0.556146 | 4 | 0 | 3 |
| CAPZA3 | KRT13 | 0.553901 | 4 | 0 | 4 |
| CAPZA3 | LDHAL6B | 0.553752 | 3 | 0 | 3 |
| CAPZA3 | MIXL1 | 0.55246 | 4 | 0 | 3 |
For details and further investigation, click here
