CARD11

 

Full name: caspase recruitment domain family member 11 Alias Symbol: CARMA1|BIMP3
Type: protein-coding gene Cytoband: 7p22.2
Entrez ID: 84433 HGNC ID: HGNC:16393 Ensembl Gene: ENSG00000198286 OMIM ID: 607210
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CARD11 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway

 

Expression of CARD11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CARD11 84433 223514_at 0.0109 0.9813
GSE26886 CARD11 84433 223514_at 0.3168 0.2878
GSE45670 CARD11 84433 223514_at 0.0059 0.9583
GSE53622 CARD11 84433 7607 0.1341 0.0411
GSE53624 CARD11 84433 7607 0.0080 0.9417
GSE63941 CARD11 84433 223514_at 0.1196 0.7354
GSE77861 CARD11 84433 223514_at 0.2083 0.3494
GSE97050 CARD11 84433 A_23_P82324 0.2533 0.2491
SRP064894 CARD11 84433 RNAseq 0.3182 0.3326
SRP133303 CARD11 84433 RNAseq -0.1586 0.6061
SRP159526 CARD11 84433 RNAseq -0.5012 0.5854
SRP193095 CARD11 84433 RNAseq 0.6125 0.0784
SRP219564 CARD11 84433 RNAseq 0.7132 0.1517
TCGA CARD11 84433 RNAseq 0.4416 0.0738

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CARD11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CARD11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CARD11 84433 15 1 14
GSE20123 CARD11 84433 15 1 14
GSE43470 CARD11 84433 7 2 34
GSE46452 CARD11 84433 13 1 45
GSE47630 CARD11 84433 10 1 29
GSE54993 CARD11 84433 0 7 63
GSE54994 CARD11 84433 22 2 29
GSE60625 CARD11 84433 0 0 11
GSE74703 CARD11 84433 7 1 28
GSE74704 CARD11 84433 9 0 11
TCGA CARD11 84433 56 5 35

Total number of gains: 154; Total number of losses: 21; Total Number of normals: 313.  

 

Somatic mutations of CARD11:

 

Generating mutation plots.

 

Highly correlated genes for CARD11:

 

Showing top 20/138 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CARD11PMM20.785166303
CARD11POU2F20.740333303
CARD11PPP5C0.727274303
CARD11DPP30.71997303
CARD11LRRK10.711305303
CARD11ACAP10.71104303
CARD11SLC11A10.698102404
CARD11SLAMF70.695366303
CARD11PRPS1L10.693661303
CARD11OR2T120.691162303
CARD11SCARB10.690305303
CARD11CNTNAP10.688795404
CARD11PLA2G70.682122303
CARD11FCHO10.678053303
CARD11AP3B20.673912303
CARD11CD720.671057303
CARD11CBFA2T30.670412403
CARD11FAM155B0.669793303
CARD11CYP26C10.667795303
CARD11TP53AIP10.662224303

For details and further investigation, click here