| Full name: caspase recruitment domain family member 6 | Alias Symbol: CINCIN1 | ||
| Type: protein-coding gene | Cytoband: 5p13.1 | ||
| Entrez ID: 84674 | HGNC ID: HGNC:16394 | Ensembl Gene: ENSG00000132357 | OMIM ID: 609986 |
| Drug and gene relationship at DGIdb | |||
CARD6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of CARD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CARD6 | 84674 | 224414_s_at | -0.5963 | 0.5141 | |
| GSE26886 | CARD6 | 84674 | 224414_s_at | -1.6292 | 0.0021 | |
| GSE45670 | CARD6 | 84674 | 224414_s_at | 0.0319 | 0.9350 | |
| GSE53622 | CARD6 | 84674 | 5347 | -0.5808 | 0.0000 | |
| GSE53624 | CARD6 | 84674 | 106150 | -1.0643 | 0.0000 | |
| GSE63941 | CARD6 | 84674 | 224414_s_at | -2.3154 | 0.0670 | |
| GSE77861 | CARD6 | 84674 | 224414_s_at | -1.4599 | 0.0030 | |
| GSE97050 | CARD6 | 84674 | A_33_P3340847 | 0.2460 | 0.4779 | |
| SRP007169 | CARD6 | 84674 | RNAseq | -2.4765 | 0.0000 | |
| SRP008496 | CARD6 | 84674 | RNAseq | -2.2364 | 0.0000 | |
| SRP064894 | CARD6 | 84674 | RNAseq | -0.5440 | 0.0038 | |
| SRP133303 | CARD6 | 84674 | RNAseq | -0.6844 | 0.0085 | |
| SRP159526 | CARD6 | 84674 | RNAseq | -1.2863 | 0.0423 | |
| SRP193095 | CARD6 | 84674 | RNAseq | -1.1375 | 0.0000 | |
| SRP219564 | CARD6 | 84674 | RNAseq | -1.0179 | 0.0395 | |
| TCGA | CARD6 | 84674 | RNAseq | -0.2017 | 0.1323 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by CARD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CARD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CARD6 | 84674 | 9 | 0 | 21 | |
| GSE20123 | CARD6 | 84674 | 9 | 0 | 21 | |
| GSE43470 | CARD6 | 84674 | 17 | 0 | 26 | |
| GSE46452 | CARD6 | 84674 | 5 | 22 | 32 | |
| GSE47630 | CARD6 | 84674 | 6 | 12 | 22 | |
| GSE54993 | CARD6 | 84674 | 5 | 4 | 61 | |
| GSE54994 | CARD6 | 84674 | 24 | 2 | 27 | |
| GSE60625 | CARD6 | 84674 | 0 | 0 | 11 | |
| GSE74703 | CARD6 | 84674 | 13 | 0 | 23 | |
| GSE74704 | CARD6 | 84674 | 8 | 0 | 12 | |
| TCGA | CARD6 | 84674 | 53 | 6 | 37 |
Total number of gains: 149; Total number of losses: 46; Total Number of normals: 293.
Somatic mutations of CARD6:
Generating mutation plots.
Highly correlated genes for CARD6:
Showing top 20/465 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CARD6 | RIPK4 | 0.759065 | 4 | 0 | 4 |
| CARD6 | KCNT1 | 0.740354 | 3 | 0 | 3 |
| CARD6 | TRIM14 | 0.73325 | 3 | 0 | 3 |
| CARD6 | STAP2 | 0.733215 | 3 | 0 | 3 |
| CARD6 | RIT1 | 0.704594 | 3 | 0 | 3 |
| CARD6 | VILL | 0.700326 | 4 | 0 | 3 |
| CARD6 | DLK2 | 0.691256 | 3 | 0 | 3 |
| CARD6 | MPZL2 | 0.681314 | 6 | 0 | 5 |
| CARD6 | VPS33B | 0.681282 | 3 | 0 | 3 |
| CARD6 | SPAG17 | 0.680295 | 4 | 0 | 4 |
| CARD6 | TMEM154 | 0.679418 | 7 | 0 | 7 |
| CARD6 | MFSD1 | 0.677492 | 7 | 0 | 6 |
| CARD6 | SDCBP2 | 0.676033 | 3 | 0 | 3 |
| CARD6 | C6orf132 | 0.675965 | 7 | 0 | 7 |
| CARD6 | GSKIP | 0.672819 | 6 | 0 | 5 |
| CARD6 | CBLN4 | 0.671695 | 3 | 0 | 3 |
| CARD6 | NPEPPS | 0.666215 | 6 | 0 | 6 |
| CARD6 | SLC10A6 | 0.662888 | 3 | 0 | 3 |
| CARD6 | CD24 | 0.660657 | 7 | 0 | 7 |
| CARD6 | DEGS2 | 0.659129 | 6 | 0 | 6 |
For details and further investigation, click here
