| Full name: cancer susceptibility 1 | Alias Symbol: LAS1|FLJ10921|PPP1R54 | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 55259 | HGNC ID: HGNC:29599 | Ensembl Gene: ENSG00000118307 | OMIM ID: 616906 |
| Drug and gene relationship at DGIdb | |||
Expression of CASC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASC1 | 55259 | 220168_at | -0.0726 | 0.8163 | |
| GSE20347 | CASC1 | 55259 | 220168_at | 0.0575 | 0.3515 | |
| GSE23400 | CASC1 | 55259 | 220168_at | -0.0654 | 0.0007 | |
| GSE26886 | CASC1 | 55259 | 220168_at | 0.2709 | 0.2188 | |
| GSE29001 | CASC1 | 55259 | 220168_at | -0.0170 | 0.9168 | |
| GSE38129 | CASC1 | 55259 | 220168_at | 0.1068 | 0.2919 | |
| GSE45670 | CASC1 | 55259 | 220168_at | 0.0033 | 0.9774 | |
| GSE53622 | CASC1 | 55259 | 145698 | -0.2111 | 0.1179 | |
| GSE53624 | CASC1 | 55259 | 145698 | -0.3939 | 0.0005 | |
| GSE63941 | CASC1 | 55259 | 220168_at | 0.0457 | 0.9166 | |
| GSE77861 | CASC1 | 55259 | 220168_at | -0.0508 | 0.6006 | |
| SRP133303 | CASC1 | 55259 | RNAseq | 0.5114 | 0.3716 | |
| TCGA | CASC1 | 55259 | RNAseq | -0.5692 | 0.3283 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CASC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASC1 | 55259 | 10 | 1 | 19 | |
| GSE20123 | CASC1 | 55259 | 10 | 1 | 19 | |
| GSE43470 | CASC1 | 55259 | 9 | 4 | 30 | |
| GSE46452 | CASC1 | 55259 | 10 | 1 | 48 | |
| GSE47630 | CASC1 | 55259 | 15 | 0 | 25 | |
| GSE54993 | CASC1 | 55259 | 0 | 9 | 61 | |
| GSE54994 | CASC1 | 55259 | 11 | 2 | 40 | |
| GSE60625 | CASC1 | 55259 | 0 | 1 | 10 | |
| GSE74703 | CASC1 | 55259 | 9 | 3 | 24 | |
| GSE74704 | CASC1 | 55259 | 6 | 1 | 13 | |
| TCGA | CASC1 | 55259 | 43 | 4 | 49 |
Total number of gains: 123; Total number of losses: 27; Total Number of normals: 338.
Somatic mutations of CASC1:
Generating mutation plots.
Highly correlated genes for CASC1:
Showing top 20/56 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASC1 | CLDN3 | 0.691907 | 5 | 0 | 5 |
| CASC1 | GPX7 | 0.661647 | 3 | 0 | 3 |
| CASC1 | WDR35 | 0.656629 | 4 | 0 | 3 |
| CASC1 | TMEM170B | 0.6228 | 3 | 0 | 3 |
| CASC1 | MICU1 | 0.617949 | 3 | 0 | 3 |
| CASC1 | BCL2 | 0.611877 | 7 | 0 | 5 |
| CASC1 | YPEL1 | 0.60182 | 8 | 0 | 6 |
| CASC1 | LRP6 | 0.59382 | 6 | 0 | 5 |
| CASC1 | MAATS1 | 0.584063 | 4 | 0 | 3 |
| CASC1 | CRNKL1 | 0.579992 | 3 | 0 | 3 |
| CASC1 | NUPR1 | 0.575219 | 4 | 0 | 3 |
| CASC1 | NPTX2 | 0.574247 | 6 | 0 | 3 |
| CASC1 | SLC41A3 | 0.571481 | 4 | 0 | 3 |
| CASC1 | RNFT2 | 0.565987 | 5 | 0 | 4 |
| CASC1 | CCKBR | 0.565944 | 4 | 0 | 3 |
| CASC1 | MAP9 | 0.56483 | 5 | 0 | 4 |
| CASC1 | CAMTA1 | 0.564512 | 4 | 0 | 3 |
| CASC1 | PIFO | 0.563188 | 5 | 0 | 4 |
| CASC1 | COL9A1 | 0.562392 | 4 | 0 | 3 |
| CASC1 | KCNT2 | 0.560705 | 5 | 0 | 3 |
For details and further investigation, click here
