| Full name: RB transcriptional corepressor like 1 | Alias Symbol: p107|cp107|PRB1 | ||
| Type: protein-coding gene | Cytoband: 20q11.23 | ||
| Entrez ID: 5933 | HGNC ID: HGNC:9893 | Ensembl Gene: ENSG00000080839 | OMIM ID: 116957 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RBL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04350 | TGF-beta signaling pathway |
Expression of RBL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBL1 | 5933 | 205296_at | 1.4148 | 0.0331 | |
| GSE20347 | RBL1 | 5933 | 205296_at | 0.8543 | 0.0002 | |
| GSE23400 | RBL1 | 5933 | 205296_at | 0.2698 | 0.0000 | |
| GSE26886 | RBL1 | 5933 | 205296_at | -0.1868 | 0.3461 | |
| GSE29001 | RBL1 | 5933 | 205296_at | 1.4118 | 0.0010 | |
| GSE38129 | RBL1 | 5933 | 205296_at | 1.0029 | 0.0000 | |
| GSE45670 | RBL1 | 5933 | 205296_at | 0.9725 | 0.0011 | |
| GSE53622 | RBL1 | 5933 | 16359 | 1.3817 | 0.0000 | |
| GSE53624 | RBL1 | 5933 | 163337 | 1.2700 | 0.0000 | |
| GSE63941 | RBL1 | 5933 | 205296_at | 0.6306 | 0.1699 | |
| GSE77861 | RBL1 | 5933 | 1555003_at | -0.1452 | 0.2323 | |
| GSE97050 | RBL1 | 5933 | A_24_P276102 | 1.4861 | 0.0781 | |
| SRP007169 | RBL1 | 5933 | RNAseq | 0.8133 | 0.1773 | |
| SRP008496 | RBL1 | 5933 | RNAseq | 1.0389 | 0.0092 | |
| SRP064894 | RBL1 | 5933 | RNAseq | 1.1076 | 0.0000 | |
| SRP133303 | RBL1 | 5933 | RNAseq | 1.1587 | 0.0000 | |
| SRP159526 | RBL1 | 5933 | RNAseq | 0.7979 | 0.0132 | |
| SRP193095 | RBL1 | 5933 | RNAseq | 0.8788 | 0.0000 | |
| SRP219564 | RBL1 | 5933 | RNAseq | 1.0994 | 0.0138 | |
| TCGA | RBL1 | 5933 | RNAseq | 0.6789 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by RBL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBL1 | 5933 | 14 | 2 | 14 | |
| GSE20123 | RBL1 | 5933 | 14 | 2 | 14 | |
| GSE43470 | RBL1 | 5933 | 12 | 0 | 31 | |
| GSE46452 | RBL1 | 5933 | 29 | 0 | 30 | |
| GSE47630 | RBL1 | 5933 | 24 | 0 | 16 | |
| GSE54993 | RBL1 | 5933 | 0 | 17 | 53 | |
| GSE54994 | RBL1 | 5933 | 24 | 0 | 29 | |
| GSE60625 | RBL1 | 5933 | 0 | 0 | 11 | |
| GSE74703 | RBL1 | 5933 | 11 | 0 | 25 | |
| GSE74704 | RBL1 | 5933 | 10 | 1 | 9 | |
| TCGA | RBL1 | 5933 | 47 | 3 | 46 |
Total number of gains: 185; Total number of losses: 25; Total Number of normals: 278.
Somatic mutations of RBL1:
Generating mutation plots.
Highly correlated genes for RBL1:
Showing top 20/962 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBL1 | GFM1 | 0.760746 | 4 | 0 | 4 |
| RBL1 | RNF149 | 0.754676 | 3 | 0 | 3 |
| RBL1 | NOP56 | 0.749854 | 3 | 0 | 3 |
| RBL1 | PYCR2 | 0.748027 | 3 | 0 | 3 |
| RBL1 | MMS22L | 0.745311 | 3 | 0 | 3 |
| RBL1 | MAD2L2 | 0.743139 | 4 | 0 | 4 |
| RBL1 | XPO5 | 0.741654 | 5 | 0 | 5 |
| RBL1 | ZDHHC16 | 0.740738 | 5 | 0 | 5 |
| RBL1 | EBNA1BP2 | 0.73753 | 3 | 0 | 3 |
| RBL1 | DKC1 | 0.735102 | 3 | 0 | 3 |
| RBL1 | ANAPC1 | 0.73276 | 3 | 0 | 3 |
| RBL1 | ZNF707 | 0.729856 | 3 | 0 | 3 |
| RBL1 | KHDC1 | 0.72972 | 3 | 0 | 3 |
| RBL1 | LSM5 | 0.723724 | 9 | 0 | 8 |
| RBL1 | MYBL2 | 0.723383 | 10 | 0 | 9 |
| RBL1 | PDE7A | 0.722451 | 5 | 0 | 5 |
| RBL1 | CAGE1 | 0.717588 | 4 | 0 | 4 |
| RBL1 | MTBP | 0.717411 | 6 | 0 | 5 |
| RBL1 | TPX2 | 0.714693 | 11 | 0 | 9 |
| RBL1 | SNAP47 | 0.714359 | 3 | 0 | 3 |
For details and further investigation, click here
