| Full name: coiled-coil domain containing 74B | Alias Symbol: DKFZp434E2321 | ||
| Type: protein-coding gene | Cytoband: 2q21.1 | ||
| Entrez ID: 91409 | HGNC ID: HGNC:25267 | Ensembl Gene: ENSG00000152076 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CCDC74B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CCDC74B | 91409 | 86082 | 0.5145 | 0.0028 | |
| GSE53624 | CCDC74B | 91409 | 86082 | 0.6877 | 0.0000 | |
| GSE97050 | CCDC74B | 91409 | A_33_P3303212 | -0.0659 | 0.7663 | |
| SRP133303 | CCDC74B | 91409 | RNAseq | 1.6359 | 0.0005 | |
| SRP159526 | CCDC74B | 91409 | RNAseq | 4.2979 | 0.0000 | |
| SRP219564 | CCDC74B | 91409 | RNAseq | -0.2251 | 0.7186 | |
| TCGA | CCDC74B | 91409 | RNAseq | 1.1350 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CCDC74B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCDC74B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCDC74B | 91409 | 5 | 3 | 22 | |
| GSE20123 | CCDC74B | 91409 | 5 | 3 | 22 | |
| GSE43470 | CCDC74B | 91409 | 2 | 2 | 39 | |
| GSE46452 | CCDC74B | 91409 | 1 | 3 | 55 | |
| GSE47630 | CCDC74B | 91409 | 5 | 0 | 35 | |
| GSE54993 | CCDC74B | 91409 | 0 | 6 | 64 | |
| GSE54994 | CCDC74B | 91409 | 11 | 0 | 42 | |
| GSE60625 | CCDC74B | 91409 | 0 | 3 | 8 | |
| GSE74703 | CCDC74B | 91409 | 2 | 1 | 33 | |
| GSE74704 | CCDC74B | 91409 | 3 | 1 | 16 | |
| TCGA | CCDC74B | 91409 | 22 | 9 | 65 |
Total number of gains: 56; Total number of losses: 31; Total Number of normals: 401.
Somatic mutations of CCDC74B:
Generating mutation plots.
Highly correlated genes for CCDC74B:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCDC74B | C12orf57 | 0.6887 | 3 | 0 | 3 |
| CCDC74B | RAB34 | 0.665182 | 3 | 0 | 3 |
| CCDC74B | DZIP1 | 0.654038 | 3 | 0 | 3 |
| CCDC74B | E2F5 | 0.648256 | 3 | 0 | 3 |
| CCDC74B | MEX3B | 0.639955 | 3 | 0 | 3 |
| CCDC74B | TWSG1 | 0.614251 | 4 | 0 | 3 |
| CCDC74B | FZD1 | 0.612031 | 3 | 0 | 3 |
| CCDC74B | HIP1 | 0.611349 | 4 | 0 | 3 |
| CCDC74B | TGIF2 | 0.608444 | 3 | 0 | 3 |
| CCDC74B | ETV5 | 0.603536 | 4 | 0 | 3 |
| CCDC74B | FZD2 | 0.603068 | 4 | 0 | 3 |
| CCDC74B | GPX7 | 0.596376 | 4 | 0 | 3 |
| CCDC74B | TUSC3 | 0.583608 | 3 | 0 | 3 |
| CCDC74B | RABL2A | 0.579948 | 4 | 0 | 3 |
| CCDC74B | AP3M2 | 0.576912 | 4 | 0 | 3 |
| CCDC74B | ZNF275 | 0.557694 | 4 | 0 | 3 |
| CCDC74B | HEY1 | 0.54814 | 4 | 0 | 3 |
| CCDC74B | GRB10 | 0.535118 | 4 | 0 | 3 |
| CCDC74B | CEP78 | 0.532676 | 3 | 0 | 3 |
| CCDC74B | LAMC1 | 0.527623 | 4 | 0 | 3 |
For details and further investigation, click here
