E2F5

 

Full name: E2F transcription factor 5 Alias Symbol: 
Type: protein-coding gene Cytoband: 8q21.2
Entrez ID: 1875 HGNC ID: HGNC:3119 Ensembl Gene: ENSG00000133740 OMIM ID: 600967
Drug and gene relationship at DGIdb

 

E2F5 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway

 

Expression of E2F5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 E2F5 1875 221586_s_at 0.7009 0.1811
GSE20347 E2F5 1875 221586_s_at 0.3065 0.1649
GSE23400 E2F5 1875 221586_s_at 0.1304 0.0351
GSE29001 E2F5 1875 221586_s_at 0.0564 0.8565
GSE38129 E2F5 1875 221586_s_at 0.3871 0.0237
GSE45670 E2F5 1875 221586_s_at 0.1131 0.7024
GSE53622 E2F5 1875 67144 0.4678 0.0020
GSE53624 E2F5 1875 44502 -0.0371 0.7268
GSE63941 E2F5 1875 221586_s_at 1.1507 0.1849
GSE97050 E2F5 1875 A_23_P31721 0.5871 0.2318
SRP007169 E2F5 1875 RNAseq 1.0286 0.1490
SRP064894 E2F5 1875 RNAseq 0.1484 0.6227
SRP133303 E2F5 1875 RNAseq 0.1194 0.6722
SRP159526 E2F5 1875 RNAseq 0.8251 0.0999
SRP193095 E2F5 1875 RNAseq 0.3041 0.1935
SRP219564 E2F5 1875 RNAseq 0.4768 0.5232
TCGA E2F5 1875 RNAseq -0.0894 0.6544

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by E2F5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of E2F5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 E2F5 1875 13 2 15
GSE20123 E2F5 1875 15 2 13
GSE43470 E2F5 1875 18 1 24
GSE46452 E2F5 1875 21 0 38
GSE47630 E2F5 1875 23 0 17
GSE54993 E2F5 1875 0 19 51
GSE54994 E2F5 1875 29 1 23
GSE60625 E2F5 1875 0 4 7
GSE74703 E2F5 1875 15 1 20
GSE74704 E2F5 1875 10 0 10
TCGA E2F5 1875 54 2 40

Total number of gains: 198; Total number of losses: 32; Total Number of normals: 258.  

 

Somatic mutations of E2F5:

 

Generating mutation plots.

 

Highly correlated genes for E2F5:

 

Showing top 20/210 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
E2F5HOXD80.785083303
E2F5B3GALT60.750376303
E2F5TP53RK0.737181303
E2F5NAT100.718706404
E2F5SSR30.716112303
E2F5TYW50.711875303
E2F5PUS7L0.710634303
E2F5CXXC10.703975303
E2F5MED10.70262303
E2F5POLDIP20.698348303
E2F5CDC370.697842303
E2F5LRRC8B0.693494303
E2F5GLA0.684599303
E2F5TTLL40.682463505
E2F5ZZZ30.679952404
E2F5ZXDC0.672014303
E2F5PPP1R80.669089404
E2F5SLC39A100.666375403
E2F5B4GALT30.665361503
E2F5TP53I130.665333303

For details and further investigation, click here