| Full name: iodothyronine deiodinase 2 | Alias Symbol: TXDI2|SelY | ||
| Type: protein-coding gene | Cytoband: 14q31.1 | ||
| Entrez ID: 1734 | HGNC ID: HGNC:2884 | Ensembl Gene: ENSG00000211448 | OMIM ID: 601413 |
| Drug and gene relationship at DGIdb | |||
Expression of DIO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIO2 | 1734 | 231240_at | -2.1082 | 0.0808 | |
| GSE20347 | DIO2 | 1734 | 203699_s_at | -2.8467 | 0.0000 | |
| GSE23400 | DIO2 | 1734 | 211215_x_at | -0.7259 | 0.0000 | |
| GSE26886 | DIO2 | 1734 | 231240_at | -4.9493 | 0.0000 | |
| GSE29001 | DIO2 | 1734 | 203699_s_at | -3.5896 | 0.0000 | |
| GSE38129 | DIO2 | 1734 | 203699_s_at | -1.8995 | 0.0000 | |
| GSE45670 | DIO2 | 1734 | 203699_s_at | -0.3373 | 0.7361 | |
| GSE53622 | DIO2 | 1734 | 63568 | -0.7368 | 0.0000 | |
| GSE53624 | DIO2 | 1734 | 63568 | -1.2316 | 0.0000 | |
| GSE63941 | DIO2 | 1734 | 211215_x_at | -0.3367 | 0.3233 | |
| GSE77861 | DIO2 | 1734 | 203700_s_at | -1.6259 | 0.0051 | |
| GSE97050 | DIO2 | 1734 | A_23_P48740 | -0.1920 | 0.7886 | |
| SRP007169 | DIO2 | 1734 | RNAseq | -2.7767 | 0.0000 | |
| SRP008496 | DIO2 | 1734 | RNAseq | -2.6543 | 0.0000 | |
| SRP064894 | DIO2 | 1734 | RNAseq | -2.3013 | 0.0000 | |
| SRP133303 | DIO2 | 1734 | RNAseq | -0.8394 | 0.0051 | |
| SRP159526 | DIO2 | 1734 | RNAseq | -3.7693 | 0.0000 | |
| SRP193095 | DIO2 | 1734 | RNAseq | -1.8503 | 0.0000 | |
| SRP219564 | DIO2 | 1734 | RNAseq | -3.0484 | 0.0001 | |
| TCGA | DIO2 | 1734 | RNAseq | 0.1215 | 0.4145 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by DIO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIO2 | 1734 | 7 | 3 | 20 | |
| GSE20123 | DIO2 | 1734 | 7 | 3 | 20 | |
| GSE43470 | DIO2 | 1734 | 7 | 3 | 33 | |
| GSE46452 | DIO2 | 1734 | 16 | 3 | 40 | |
| GSE47630 | DIO2 | 1734 | 11 | 8 | 21 | |
| GSE54993 | DIO2 | 1734 | 3 | 8 | 59 | |
| GSE54994 | DIO2 | 1734 | 19 | 4 | 30 | |
| GSE60625 | DIO2 | 1734 | 0 | 2 | 9 | |
| GSE74703 | DIO2 | 1734 | 6 | 3 | 27 | |
| GSE74704 | DIO2 | 1734 | 3 | 3 | 14 | |
| TCGA | DIO2 | 1734 | 30 | 19 | 47 |
Total number of gains: 109; Total number of losses: 59; Total Number of normals: 320.
Somatic mutations of DIO2:
Generating mutation plots.
Highly correlated genes for DIO2:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIO2 | CLIC3 | 0.808432 | 8 | 0 | 8 |
| DIO2 | SPNS2 | 0.791171 | 4 | 0 | 4 |
| DIO2 | NICN1 | 0.78845 | 3 | 0 | 3 |
| DIO2 | PRSS3 | 0.780354 | 10 | 0 | 10 |
| DIO2 | SPAG17 | 0.779232 | 4 | 0 | 4 |
| DIO2 | PTK6 | 0.76917 | 11 | 0 | 11 |
| DIO2 | CEACAM7 | 0.767227 | 11 | 0 | 11 |
| DIO2 | ENDOU | 0.76546 | 10 | 0 | 10 |
| DIO2 | HOPX | 0.765334 | 10 | 0 | 10 |
| DIO2 | CYSRT1 | 0.763237 | 6 | 0 | 6 |
| DIO2 | FAM3D | 0.75629 | 6 | 0 | 6 |
| DIO2 | PPL | 0.752954 | 10 | 0 | 10 |
| DIO2 | GDPD3 | 0.752804 | 10 | 0 | 10 |
| DIO2 | SLC13A4 | 0.749308 | 11 | 0 | 11 |
| DIO2 | SFTA2 | 0.748868 | 4 | 0 | 4 |
| DIO2 | TRNP1 | 0.748799 | 6 | 0 | 6 |
| DIO2 | PADI1 | 0.747804 | 8 | 0 | 7 |
| DIO2 | ATP13A4 | 0.747681 | 6 | 0 | 6 |
| DIO2 | CRISP3 | 0.747148 | 10 | 0 | 10 |
| DIO2 | SERPINB1 | 0.745207 | 10 | 0 | 10 |
For details and further investigation, click here
