CXCL8

 

Full name: C-X-C motif chemokine ligand 8 Alias Symbol: SCYB8|LUCT|LECT|MDNCF|TSG-1|IL-8|NAP-1|3-10C|MONAP|AMCF-I|LYNAP|NAF|b-ENAP|GCP-1|K60|GCP1|NAP1
Type: protein-coding gene Cytoband: 4q13.3
Entrez ID: 3576 HGNC ID: HGNC:6025 Ensembl Gene: ENSG00000169429 OMIM ID: 146930
Drug and gene relationship at DGIdb

 

CXCL8 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05134Legionellosis
hsa05161Hepatitis B
hsa05200Pathways in cancer

 

Expression of CXCL8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CXCL8 3576 202859_x_at 3.2397 0.1835
GSE20347 CXCL8 3576 202859_x_at 3.4958 0.0000
GSE23400 CXCL8 3576 202859_x_at 1.9728 0.0000
GSE26886 CXCL8 3576 202859_x_at 2.7255 0.0146
GSE29001 CXCL8 3576 202859_x_at 2.1789 0.0005
GSE38129 CXCL8 3576 202859_x_at 2.9487 0.0000
GSE45670 CXCL8 3576 202859_x_at 3.5433 0.0001
GSE53622 CXCL8 3576 65492 3.3136 0.0000
GSE53624 CXCL8 3576 35253 3.6532 0.0000
GSE63941 CXCL8 3576 202859_x_at -0.5837 0.8308
GSE77861 CXCL8 3576 202859_x_at 3.3868 0.0020
SRP007169 CXCL8 3576 RNAseq 5.1097 0.0000
SRP008496 CXCL8 3576 RNAseq 3.6138 0.0001
SRP064894 CXCL8 3576 RNAseq 4.5449 0.0000
SRP133303 CXCL8 3576 RNAseq 4.2371 0.0000
SRP159526 CXCL8 3576 RNAseq 4.1609 0.0000
SRP193095 CXCL8 3576 RNAseq 5.4689 0.0000
SRP219564 CXCL8 3576 RNAseq 4.2031 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by CXCL8 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of CXCL8:

 

No record found for this gene.

 

Somatic mutations of CXCL8:

 

Generating mutation plots.

 

Highly correlated genes for CXCL8:

 

Showing top 20/1233 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CXCL8CXCL10.85073811011
CXCL8MMP10.78716610010
CXCL8MMP120.77448610010
CXCL8MMP30.74215110010
CXCL8PLAUR0.73340310010
CXCL8STRIP20.725109606
CXCL8MTHFD20.71907610010
CXCL8C11orf240.7122510010
CXCL8LAMC20.7117110010
CXCL8MET0.7095121008
CXCL8CEBPB0.7077310010
CXCL8SLC25A320.70150710010
CXCL8CDC25B0.7014991009
CXCL8FMNL20.700162606
CXCL8SPP10.6992561009
CXCL8TNFRSF10B0.69753410010
CXCL8EME10.697148404
CXCL8PLAU0.69663411010
CXCL8ISG150.695066909
CXCL8UHRF10.694724605

For details and further investigation, click here