GBP4

 

Full name: guanylate binding protein 4 Alias Symbol: Mpa2
Type: protein-coding gene Cytoband: 1p22.2
Entrez ID: 115361 HGNC ID: HGNC:20480 Ensembl Gene: ENSG00000162654 OMIM ID: 612466
Drug and gene relationship at DGIdb

 

Expression of GBP4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GBP4 115361 235175_at -0.1005 0.9396
GSE26886 GBP4 115361 235175_at -0.1863 0.6494
GSE45670 GBP4 115361 235175_at 0.1135 0.7804
GSE53622 GBP4 115361 7577 0.2443 0.0962
GSE53624 GBP4 115361 7577 0.1139 0.3167
GSE63941 GBP4 115361 235574_at 0.3459 0.6715
GSE77861 GBP4 115361 235175_at -0.1939 0.1156
GSE97050 GBP4 115361 A_24_P45446 0.3767 0.4258
SRP007169 GBP4 115361 RNAseq -1.1478 0.0242
SRP008496 GBP4 115361 RNAseq -1.1740 0.0009
SRP064894 GBP4 115361 RNAseq 0.0512 0.8173
SRP133303 GBP4 115361 RNAseq 0.2809 0.3087
SRP193095 GBP4 115361 RNAseq 0.1407 0.3592
SRP219564 GBP4 115361 RNAseq 1.2753 0.0653
TCGA GBP4 115361 RNAseq 0.1667 0.2855

Upregulated datasets: 0; Downregulated datasets: 2.  


 

Survival by GBP4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of GBP4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GBP4 115361 0 8 22
GSE20123 GBP4 115361 0 8 22
GSE43470 GBP4 115361 2 4 37
GSE46452 GBP4 115361 1 1 57
GSE47630 GBP4 115361 8 5 27
GSE54993 GBP4 115361 0 1 69
GSE54994 GBP4 115361 6 2 45
GSE60625 GBP4 115361 0 0 11
GSE74703 GBP4 115361 1 3 32
GSE74704 GBP4 115361 0 5 15
TCGA GBP4 115361 6 23 67

Total number of gains: 24; Total number of losses: 60; Total Number of normals: 404.  


 

Somatic mutations of GBP4:

 

Generating mutation plots.

 

Highly correlated genes for GBP4:

 

Showing top 20/230 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GBP4APOL60.713428605
GBP4CXCL110.708635808
GBP4CXCL100.701905808
GBP4APOBEC3G0.69692606
GBP4IDO10.696535808
GBP4ZNF804A0.688845303
GBP4FMN10.68399303
GBP4CD8A0.6838606
GBP4NOA10.682532303
GBP4NKG70.671831807
GBP4SAMD9L0.668577908
GBP4IRF10.66683706
GBP4TRIM220.664932908
GBP4EPSTI10.664232707
GBP4BTN2A20.659274403
GBP4GZMA0.65779806
GBP4IFNK0.649028303
GBP4SIRPG0.648032606
GBP4UBA70.647936404
GBP4NPRL20.647853303

For details and further investigation, click here