| Full name: cell division cycle 14B | Alias Symbol: Cdc14B1|Cdc14B2|CDC14B3|hCDC14B | ||
| Type: protein-coding gene | Cytoband: 9q22.32-q22.33 | ||
| Entrez ID: 8555 | HGNC ID: HGNC:1719 | Ensembl Gene: ENSG00000081377 | OMIM ID: 603505 |
| Drug and gene relationship at DGIdb | |||
CDC14B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDC14B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC14B | 8555 | 221556_at | 0.3027 | 0.6178 | |
| GSE20347 | CDC14B | 8555 | 221555_x_at | 0.4105 | 0.0108 | |
| GSE23400 | CDC14B | 8555 | 221555_x_at | -0.0716 | 0.1634 | |
| GSE26886 | CDC14B | 8555 | 221555_x_at | 0.6324 | 0.0842 | |
| GSE29001 | CDC14B | 8555 | 221555_x_at | 0.1688 | 0.6412 | |
| GSE38129 | CDC14B | 8555 | 221555_x_at | 0.1989 | 0.2903 | |
| GSE45670 | CDC14B | 8555 | 221556_at | -0.1420 | 0.6421 | |
| GSE53622 | CDC14B | 8555 | 53137 | -0.1644 | 0.1682 | |
| GSE53624 | CDC14B | 8555 | 53137 | 0.2317 | 0.0218 | |
| GSE63941 | CDC14B | 8555 | 221556_at | -0.8444 | 0.1638 | |
| GSE77861 | CDC14B | 8555 | 230887_at | -0.0131 | 0.9337 | |
| GSE97050 | CDC14B | 8555 | A_33_P3231557 | -0.2045 | 0.3736 | |
| SRP007169 | CDC14B | 8555 | RNAseq | 1.5193 | 0.0081 | |
| SRP008496 | CDC14B | 8555 | RNAseq | 1.6082 | 0.0002 | |
| SRP064894 | CDC14B | 8555 | RNAseq | -0.1830 | 0.3855 | |
| SRP133303 | CDC14B | 8555 | RNAseq | 0.0328 | 0.8859 | |
| SRP159526 | CDC14B | 8555 | RNAseq | 0.3911 | 0.1239 | |
| SRP193095 | CDC14B | 8555 | RNAseq | 0.0120 | 0.9646 | |
| SRP219564 | CDC14B | 8555 | RNAseq | -0.1112 | 0.8282 | |
| TCGA | CDC14B | 8555 | RNAseq | -0.4424 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CDC14B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC14B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC14B | 8555 | 6 | 8 | 16 | |
| GSE20123 | CDC14B | 8555 | 6 | 7 | 17 | |
| GSE43470 | CDC14B | 8555 | 6 | 3 | 34 | |
| GSE46452 | CDC14B | 8555 | 6 | 14 | 39 | |
| GSE47630 | CDC14B | 8555 | 1 | 17 | 22 | |
| GSE54993 | CDC14B | 8555 | 3 | 2 | 65 | |
| GSE54994 | CDC14B | 8555 | 8 | 11 | 34 | |
| GSE60625 | CDC14B | 8555 | 0 | 0 | 11 | |
| GSE74703 | CDC14B | 8555 | 5 | 3 | 28 | |
| GSE74704 | CDC14B | 8555 | 3 | 5 | 12 | |
| TCGA | CDC14B | 8555 | 25 | 23 | 48 |
Total number of gains: 69; Total number of losses: 93; Total Number of normals: 326.
Somatic mutations of CDC14B:
Generating mutation plots.
Highly correlated genes for CDC14B:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC14B | DEXI | 0.783792 | 3 | 0 | 3 |
| CDC14B | ARHGAP42 | 0.778689 | 3 | 0 | 3 |
| CDC14B | TEX261 | 0.736028 | 3 | 0 | 3 |
| CDC14B | C15orf61 | 0.735991 | 3 | 0 | 3 |
| CDC14B | TRPM7 | 0.70684 | 3 | 0 | 3 |
| CDC14B | CLN6 | 0.69536 | 3 | 0 | 3 |
| CDC14B | DHX57 | 0.694593 | 4 | 0 | 3 |
| CDC14B | C1RL | 0.694066 | 3 | 0 | 3 |
| CDC14B | MORF4L1 | 0.688968 | 3 | 0 | 3 |
| CDC14B | GNB5 | 0.681391 | 3 | 0 | 3 |
| CDC14B | NIPA2 | 0.678851 | 3 | 0 | 3 |
| CDC14B | MTFMT | 0.675917 | 4 | 0 | 3 |
| CDC14B | KCNK2 | 0.67301 | 3 | 0 | 3 |
| CDC14B | NRSN2 | 0.668757 | 4 | 0 | 3 |
| CDC14B | ERCC2 | 0.663076 | 3 | 0 | 3 |
| CDC14B | NMT2 | 0.663034 | 4 | 0 | 3 |
| CDC14B | CD22 | 0.66119 | 3 | 0 | 3 |
| CDC14B | KLHL5 | 0.660898 | 4 | 0 | 3 |
| CDC14B | USP20 | 0.660895 | 4 | 0 | 3 |
| CDC14B | DCHS2 | 0.659329 | 3 | 0 | 3 |
For details and further investigation, click here
