| Full name: transient receptor potential cation channel subfamily M member 7 | Alias Symbol: CHAK1|LTRPC7|TRP-PLIK | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 54822 | HGNC ID: HGNC:17994 | Ensembl Gene: ENSG00000092439 | OMIM ID: 605692 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TRPM7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPM7 | 54822 | 223324_s_at | 0.2024 | 0.5714 | |
| GSE26886 | TRPM7 | 54822 | 231689_at | 0.1689 | 0.1970 | |
| GSE45670 | TRPM7 | 54822 | 223324_s_at | 0.0593 | 0.7624 | |
| GSE53622 | TRPM7 | 54822 | 21149 | 0.3476 | 0.0000 | |
| GSE53624 | TRPM7 | 54822 | 21149 | 0.3310 | 0.0002 | |
| GSE63941 | TRPM7 | 54822 | 223324_s_at | -0.8390 | 0.0815 | |
| GSE77861 | TRPM7 | 54822 | 223323_x_at | 0.0158 | 0.9332 | |
| GSE97050 | TRPM7 | 54822 | A_23_P88470 | 0.0023 | 0.9925 | |
| SRP007169 | TRPM7 | 54822 | RNAseq | 1.0855 | 0.0019 | |
| SRP008496 | TRPM7 | 54822 | RNAseq | 1.0777 | 0.0000 | |
| SRP064894 | TRPM7 | 54822 | RNAseq | 0.2525 | 0.2430 | |
| SRP133303 | TRPM7 | 54822 | RNAseq | 0.3427 | 0.0171 | |
| SRP159526 | TRPM7 | 54822 | RNAseq | -0.0110 | 0.9715 | |
| SRP193095 | TRPM7 | 54822 | RNAseq | 0.1103 | 0.1702 | |
| SRP219564 | TRPM7 | 54822 | RNAseq | 0.1598 | 0.6223 | |
| TCGA | TRPM7 | 54822 | RNAseq | -0.0590 | 0.2174 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TRPM7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPM7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPM7 | 54822 | 5 | 3 | 22 | |
| GSE20123 | TRPM7 | 54822 | 5 | 3 | 22 | |
| GSE43470 | TRPM7 | 54822 | 5 | 3 | 35 | |
| GSE46452 | TRPM7 | 54822 | 3 | 7 | 49 | |
| GSE47630 | TRPM7 | 54822 | 8 | 10 | 22 | |
| GSE54993 | TRPM7 | 54822 | 4 | 6 | 60 | |
| GSE54994 | TRPM7 | 54822 | 5 | 7 | 41 | |
| GSE60625 | TRPM7 | 54822 | 4 | 0 | 7 | |
| GSE74703 | TRPM7 | 54822 | 5 | 2 | 29 | |
| GSE74704 | TRPM7 | 54822 | 2 | 3 | 15 | |
| TCGA | TRPM7 | 54822 | 9 | 16 | 71 |
Total number of gains: 55; Total number of losses: 60; Total Number of normals: 373.
Somatic mutations of TRPM7:
Generating mutation plots.
Highly correlated genes for TRPM7:
Showing top 20/114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPM7 | ZHX2 | 0.765889 | 3 | 0 | 3 |
| TRPM7 | RNF121 | 0.723083 | 3 | 0 | 3 |
| TRPM7 | CDC14B | 0.70684 | 3 | 0 | 3 |
| TRPM7 | ADPRH | 0.700556 | 3 | 0 | 3 |
| TRPM7 | C9orf40 | 0.692029 | 3 | 0 | 3 |
| TRPM7 | LYRM2 | 0.689251 | 3 | 0 | 3 |
| TRPM7 | ZCCHC3 | 0.683414 | 3 | 0 | 3 |
| TRPM7 | POLR1B | 0.682375 | 3 | 0 | 3 |
| TRPM7 | SENP2 | 0.680209 | 4 | 0 | 4 |
| TRPM7 | NUP205 | 0.671319 | 3 | 0 | 3 |
| TRPM7 | ZC3H7B | 0.670989 | 3 | 0 | 3 |
| TRPM7 | SENP6 | 0.666785 | 3 | 0 | 3 |
| TRPM7 | ADAM23 | 0.663925 | 3 | 0 | 3 |
| TRPM7 | IL3RA | 0.662646 | 3 | 0 | 3 |
| TRPM7 | TRMT11 | 0.6623 | 3 | 0 | 3 |
| TRPM7 | SMURF2 | 0.661717 | 3 | 0 | 3 |
| TRPM7 | CTDSPL2 | 0.660545 | 5 | 0 | 4 |
| TRPM7 | TMPRSS3 | 0.658861 | 3 | 0 | 3 |
| TRPM7 | DIP2B | 0.654026 | 3 | 0 | 3 |
| TRPM7 | LRP6 | 0.651789 | 4 | 0 | 3 |
For details and further investigation, click here
