CDKN1B

 

Full name: cyclin dependent kinase inhibitor 1B Alias Symbol: KIP1|P27KIP1
Type: protein-coding gene Cytoband: 12p13.1
Entrez ID: 1027 HGNC ID: HGNC:1785 Ensembl Gene: ENSG00000111276 OMIM ID: 600778
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDKN1B involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa05162Measles
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer

 

Expression of CDKN1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDKN1B 1027 209112_at -0.5058 0.2279
GSE20347 CDKN1B 1027 209112_at -0.2292 0.1911
GSE23400 CDKN1B 1027 209112_at -0.2377 0.0669
GSE26886 CDKN1B 1027 209112_at -0.5924 0.0918
GSE29001 CDKN1B 1027 209112_at 0.0730 0.8139
GSE38129 CDKN1B 1027 209112_at -0.2728 0.0428
GSE45670 CDKN1B 1027 209112_at -0.3874 0.0385
GSE53622 CDKN1B 1027 15483 -0.2483 0.0009
GSE53624 CDKN1B 1027 15483 -0.1755 0.0089
GSE63941 CDKN1B 1027 209112_at 0.8854 0.0393
GSE77861 CDKN1B 1027 209112_at -0.1300 0.6412
GSE97050 CDKN1B 1027 A_23_P204696 0.3143 0.5024
SRP007169 CDKN1B 1027 RNAseq 0.2388 0.6471
SRP008496 CDKN1B 1027 RNAseq 0.3982 0.3062
SRP064894 CDKN1B 1027 RNAseq -0.6456 0.0003
SRP133303 CDKN1B 1027 RNAseq -0.1075 0.4884
SRP159526 CDKN1B 1027 RNAseq -0.4652 0.0222
SRP193095 CDKN1B 1027 RNAseq -0.4604 0.0003
SRP219564 CDKN1B 1027 RNAseq -0.3526 0.4201
TCGA CDKN1B 1027 RNAseq 0.0268 0.6537

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CDKN1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDKN1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDKN1B 1027 6 2 22
GSE20123 CDKN1B 1027 6 2 22
GSE43470 CDKN1B 1027 10 4 29
GSE46452 CDKN1B 1027 10 1 48
GSE47630 CDKN1B 1027 13 2 25
GSE54993 CDKN1B 1027 2 9 59
GSE54994 CDKN1B 1027 10 2 41
GSE60625 CDKN1B 1027 0 1 10
GSE74703 CDKN1B 1027 9 3 24
GSE74704 CDKN1B 1027 4 1 15
TCGA CDKN1B 1027 39 7 50

Total number of gains: 109; Total number of losses: 34; Total Number of normals: 345.  

 

Somatic mutations of CDKN1B:

 

Generating mutation plots.

 

Highly correlated genes for CDKN1B:

 

Showing top 20/303 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDKN1BAP3M10.761588303
CDKN1BMAN1A20.746123303
CDKN1BFBXO80.723419404
CDKN1BMAGT10.705315403
CDKN1BRAB4B0.701913303
CDKN1BRNF144B0.699378303
CDKN1BTNFAIP80.692872303
CDKN1BCDH10.69261303
CDKN1BIRAK40.691576404
CDKN1BNDFIP20.691436303
CDKN1BNDUFB60.69021303
CDKN1BIMPDH20.687208303
CDKN1BTMEM161B0.685613303
CDKN1BRREB10.683746303
CDKN1BMIER30.680222303
CDKN1BCEP570.671462403
CDKN1BBCL2L110.666127303
CDKN1BDYM0.663363404
CDKN1BPYROXD10.662281605
CDKN1BMACROD20.659442403

For details and further investigation, click here