| Full name: SPG7 matrix AAA peptidase subunit, paraplegin | Alias Symbol: CAR|SPG5C | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 6687 | HGNC ID: HGNC:11237 | Ensembl Gene: ENSG00000197912 | OMIM ID: 602783 |
| Drug and gene relationship at DGIdb | |||
Expression of SPG7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPG7 | 6687 | 238286_at | -0.0050 | 0.9881 | |
| GSE26886 | SPG7 | 6687 | 238286_at | 0.0245 | 0.8094 | |
| GSE45670 | SPG7 | 6687 | 238286_at | 0.0330 | 0.7182 | |
| GSE53622 | SPG7 | 6687 | 13063 | 0.0476 | 0.5148 | |
| GSE53624 | SPG7 | 6687 | 13063 | 0.2444 | 0.0002 | |
| GSE63941 | SPG7 | 6687 | 238286_at | 0.0062 | 0.9699 | |
| GSE77861 | SPG7 | 6687 | 238286_at | -0.1202 | 0.3936 | |
| GSE97050 | SPG7 | 6687 | A_23_P433990 | -0.1283 | 0.5556 | |
| SRP007169 | SPG7 | 6687 | RNAseq | 0.3492 | 0.4186 | |
| SRP008496 | SPG7 | 6687 | RNAseq | 0.3105 | 0.2932 | |
| SRP064894 | SPG7 | 6687 | RNAseq | 0.3031 | 0.0343 | |
| SRP133303 | SPG7 | 6687 | RNAseq | 0.4703 | 0.0698 | |
| SRP159526 | SPG7 | 6687 | RNAseq | 0.3485 | 0.1578 | |
| SRP193095 | SPG7 | 6687 | RNAseq | 0.3734 | 0.0012 | |
| SRP219564 | SPG7 | 6687 | RNAseq | -0.0169 | 0.9383 | |
| TCGA | SPG7 | 6687 | RNAseq | -0.1000 | 0.0327 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPG7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPG7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPG7 | 6687 | 4 | 3 | 23 | |
| GSE20123 | SPG7 | 6687 | 4 | 3 | 23 | |
| GSE43470 | SPG7 | 6687 | 1 | 13 | 29 | |
| GSE46452 | SPG7 | 6687 | 38 | 1 | 20 | |
| GSE47630 | SPG7 | 6687 | 11 | 9 | 20 | |
| GSE54993 | SPG7 | 6687 | 3 | 4 | 63 | |
| GSE54994 | SPG7 | 6687 | 9 | 11 | 33 | |
| GSE60625 | SPG7 | 6687 | 4 | 0 | 7 | |
| GSE74703 | SPG7 | 6687 | 1 | 9 | 26 | |
| GSE74704 | SPG7 | 6687 | 3 | 1 | 16 | |
| TCGA | SPG7 | 6687 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of SPG7:
Generating mutation plots.
Highly correlated genes for SPG7:
Showing top 20/29 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPG7 | HPS5 | 0.770902 | 3 | 0 | 3 |
| SPG7 | PLXNB2 | 0.743283 | 3 | 0 | 3 |
| SPG7 | CDK10 | 0.719117 | 4 | 0 | 3 |
| SPG7 | CISD1 | 0.712887 | 3 | 0 | 3 |
| SPG7 | MOB4 | 0.70511 | 3 | 0 | 3 |
| SPG7 | C8orf37 | 0.688215 | 3 | 0 | 3 |
| SPG7 | MAP1S | 0.68393 | 3 | 0 | 3 |
| SPG7 | DHX38 | 0.675218 | 5 | 0 | 5 |
| SPG7 | WDR59 | 0.666083 | 4 | 0 | 4 |
| SPG7 | ZBTB8OS | 0.66577 | 3 | 0 | 3 |
| SPG7 | ATP6AP1 | 0.665552 | 3 | 0 | 3 |
| SPG7 | ZGPAT | 0.66481 | 3 | 0 | 3 |
| SPG7 | COBLL1 | 0.638366 | 3 | 0 | 3 |
| SPG7 | MMP16 | 0.635891 | 3 | 0 | 3 |
| SPG7 | SREBF2 | 0.625993 | 4 | 0 | 3 |
| SPG7 | BRD9 | 0.621385 | 4 | 0 | 3 |
| SPG7 | PRLR | 0.618975 | 3 | 0 | 3 |
| SPG7 | DGCR8 | 0.617435 | 4 | 0 | 3 |
| SPG7 | MYH3 | 0.6103 | 4 | 0 | 3 |
| SPG7 | RHOT2 | 0.588692 | 5 | 0 | 4 |
For details and further investigation, click here
