| Full name: cyclin dependent kinase 7 | Alias Symbol: CAK1|CDKN7|MO15|STK1|CAK | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 1022 | HGNC ID: HGNC:1778 | Ensembl Gene: ENSG00000134058 | OMIM ID: 601955 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CDK7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of CDK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK7 | 1022 | 211297_s_at | -0.6755 | 0.3758 | |
| GSE20347 | CDK7 | 1022 | 211297_s_at | -1.0886 | 0.0000 | |
| GSE23400 | CDK7 | 1022 | 211297_s_at | -0.7416 | 0.0000 | |
| GSE26886 | CDK7 | 1022 | 211297_s_at | -2.0032 | 0.0000 | |
| GSE29001 | CDK7 | 1022 | 211297_s_at | -1.2393 | 0.0072 | |
| GSE38129 | CDK7 | 1022 | 211297_s_at | -0.4930 | 0.0239 | |
| GSE45670 | CDK7 | 1022 | 211297_s_at | -0.6603 | 0.0035 | |
| GSE53622 | CDK7 | 1022 | 14796 | -0.7385 | 0.0000 | |
| GSE53624 | CDK7 | 1022 | 14796 | -0.8518 | 0.0000 | |
| GSE63941 | CDK7 | 1022 | 211297_s_at | -0.2584 | 0.5663 | |
| GSE77861 | CDK7 | 1022 | 211297_s_at | -1.1997 | 0.0106 | |
| GSE97050 | CDK7 | 1022 | A_23_P133585 | 0.2212 | 0.6797 | |
| SRP007169 | CDK7 | 1022 | RNAseq | -2.2471 | 0.0000 | |
| SRP008496 | CDK7 | 1022 | RNAseq | -2.3372 | 0.0000 | |
| SRP064894 | CDK7 | 1022 | RNAseq | -1.4355 | 0.0000 | |
| SRP133303 | CDK7 | 1022 | RNAseq | -0.7811 | 0.0001 | |
| SRP159526 | CDK7 | 1022 | RNAseq | -1.1861 | 0.0000 | |
| SRP193095 | CDK7 | 1022 | RNAseq | -1.2493 | 0.0000 | |
| SRP219564 | CDK7 | 1022 | RNAseq | -1.3661 | 0.0140 | |
| TCGA | CDK7 | 1022 | RNAseq | 0.1746 | 0.0202 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by CDK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK7 | 1022 | 1 | 13 | 16 | |
| GSE20123 | CDK7 | 1022 | 1 | 13 | 16 | |
| GSE43470 | CDK7 | 1022 | 1 | 12 | 30 | |
| GSE46452 | CDK7 | 1022 | 0 | 28 | 31 | |
| GSE47630 | CDK7 | 1022 | 2 | 17 | 21 | |
| GSE54993 | CDK7 | 1022 | 8 | 1 | 61 | |
| GSE54994 | CDK7 | 1022 | 1 | 21 | 31 | |
| GSE60625 | CDK7 | 1022 | 0 | 0 | 11 | |
| GSE74703 | CDK7 | 1022 | 1 | 9 | 26 | |
| GSE74704 | CDK7 | 1022 | 1 | 6 | 13 | |
| TCGA | CDK7 | 1022 | 4 | 51 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of CDK7:
Generating mutation plots.
Highly correlated genes for CDK7:
Showing top 20/1340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK7 | RAET1E | 0.774325 | 6 | 0 | 6 |
| CDK7 | CRCT1 | 0.76677 | 10 | 0 | 10 |
| CDK7 | VSIG10L | 0.763357 | 6 | 0 | 6 |
| CDK7 | TMED3 | 0.761437 | 11 | 0 | 11 |
| CDK7 | CYSRT1 | 0.758611 | 6 | 0 | 6 |
| CDK7 | PLIN3 | 0.756625 | 11 | 0 | 11 |
| CDK7 | ITCH | 0.754665 | 10 | 0 | 10 |
| CDK7 | TP53I3 | 0.753015 | 11 | 0 | 11 |
| CDK7 | SLC46A2 | 0.752166 | 6 | 0 | 6 |
| CDK7 | PRSS27 | 0.751404 | 6 | 0 | 6 |
| CDK7 | EPG5 | 0.750055 | 3 | 0 | 3 |
| CDK7 | S100A16 | 0.747363 | 7 | 0 | 7 |
| CDK7 | GSKIP | 0.74717 | 6 | 0 | 6 |
| CDK7 | MRPS36 | 0.747082 | 7 | 0 | 7 |
| CDK7 | GYS2 | 0.743411 | 10 | 0 | 10 |
| CDK7 | EMC3 | 0.742902 | 10 | 0 | 10 |
| CDK7 | PDCD6IP | 0.742776 | 11 | 0 | 10 |
| CDK7 | CWH43 | 0.741316 | 10 | 0 | 10 |
| CDK7 | P4HB | 0.740866 | 6 | 0 | 6 |
| CDK7 | CCNYL1 | 0.740629 | 4 | 0 | 4 |
For details and further investigation, click here
