| Full name: aurora kinase B | Alias Symbol: Aik2|IPL1|AurB|AIM-1|ARK2|STK5|PPP1R48 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 9212 | HGNC ID: HGNC:11390 | Ensembl Gene: ENSG00000178999 | OMIM ID: 604970 |
| Drug and gene relationship at DGIdb | |||
Expression of AURKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AURKB | 9212 | 209464_at | 1.2692 | 0.0086 | |
| GSE20347 | AURKB | 9212 | 209464_at | 1.5355 | 0.0000 | |
| GSE23400 | AURKB | 9212 | 209464_at | 1.1708 | 0.0000 | |
| GSE26886 | AURKB | 9212 | 209464_at | 0.8316 | 0.0040 | |
| GSE29001 | AURKB | 9212 | 209464_at | 1.1702 | 0.0013 | |
| GSE38129 | AURKB | 9212 | 209464_at | 1.9500 | 0.0000 | |
| GSE45670 | AURKB | 9212 | 209464_at | 1.7481 | 0.0000 | |
| GSE53622 | AURKB | 9212 | 2017 | 1.8418 | 0.0000 | |
| GSE53624 | AURKB | 9212 | 33667 | 2.0696 | 0.0000 | |
| GSE63941 | AURKB | 9212 | 209464_at | 3.6216 | 0.0000 | |
| GSE77861 | AURKB | 9212 | 209464_at | 1.0031 | 0.0020 | |
| GSE97050 | AURKB | 9212 | A_23_P130182 | 1.7673 | 0.1446 | |
| SRP007169 | AURKB | 9212 | RNAseq | 1.9307 | 0.0001 | |
| SRP008496 | AURKB | 9212 | RNAseq | 1.2638 | 0.0006 | |
| SRP064894 | AURKB | 9212 | RNAseq | 2.2651 | 0.0000 | |
| SRP133303 | AURKB | 9212 | RNAseq | 1.6306 | 0.0000 | |
| SRP159526 | AURKB | 9212 | RNAseq | 1.9736 | 0.0000 | |
| SRP193095 | AURKB | 9212 | RNAseq | 1.4951 | 0.0000 | |
| SRP219564 | AURKB | 9212 | RNAseq | 1.9912 | 0.0131 | |
| TCGA | AURKB | 9212 | RNAseq | 1.5710 | 0.0000 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by AURKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AURKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AURKB | 9212 | 4 | 2 | 24 | |
| GSE20123 | AURKB | 9212 | 4 | 3 | 23 | |
| GSE43470 | AURKB | 9212 | 1 | 6 | 36 | |
| GSE46452 | AURKB | 9212 | 34 | 1 | 24 | |
| GSE47630 | AURKB | 9212 | 7 | 1 | 32 | |
| GSE54993 | AURKB | 9212 | 4 | 3 | 63 | |
| GSE54994 | AURKB | 9212 | 5 | 8 | 40 | |
| GSE60625 | AURKB | 9212 | 4 | 0 | 7 | |
| GSE74703 | AURKB | 9212 | 1 | 3 | 32 | |
| GSE74704 | AURKB | 9212 | 2 | 1 | 17 | |
| TCGA | AURKB | 9212 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of AURKB:
Generating mutation plots.
Highly correlated genes for AURKB:
Showing top 20/1916 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AURKB | TPX2 | 0.881489 | 13 | 0 | 13 |
| AURKB | UBE2C | 0.875198 | 13 | 0 | 13 |
| AURKB | NCAPH | 0.858584 | 9 | 0 | 9 |
| AURKB | KIF2C | 0.856647 | 12 | 0 | 12 |
| AURKB | CDC45 | 0.854291 | 12 | 0 | 12 |
| AURKB | KIF4A | 0.851661 | 12 | 0 | 11 |
| AURKB | BIRC5 | 0.842519 | 12 | 0 | 12 |
| AURKB | MYBL2 | 0.840864 | 12 | 0 | 12 |
| AURKB | CEP55 | 0.838318 | 13 | 0 | 13 |
| AURKB | RAD51 | 0.836979 | 11 | 0 | 11 |
| AURKB | TRIP13 | 0.835119 | 13 | 0 | 12 |
| AURKB | KIF14 | 0.83508 | 13 | 0 | 13 |
| AURKB | RNASEH2A | 0.832852 | 13 | 0 | 13 |
| AURKB | CDK1 | 0.831545 | 12 | 0 | 12 |
| AURKB | CKS1B | 0.83004 | 13 | 0 | 12 |
| AURKB | FOXM1 | 0.829863 | 13 | 0 | 13 |
| AURKB | CDC6 | 0.828514 | 9 | 0 | 9 |
| AURKB | NEK2 | 0.828373 | 13 | 0 | 13 |
| AURKB | CCNB2 | 0.826963 | 12 | 0 | 12 |
| AURKB | TOP2A | 0.826867 | 13 | 0 | 13 |
For details and further investigation, click here
